Cutoff value of thyroglobulin in needle aspirates for screening neck masses of thyroid carcinoma.

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  • Additional Information
    • Source:
      Publisher: BioScientifica Country of Publication: England NLM ID: 9436481 Publication Model: Electronic-Print Cited Medium: Internet ISSN: 1479-6821 (Electronic) Linking ISSN: 13510088 NLM ISO Abbreviation: Endocr Relat Cancer Subsets: MEDLINE
    • Publication Information:
      Publication: Jan. 2011- : Bristol, UK : BioScientifica
      Original Publication: Woodlands, Almondsbury, Bristol, UK : Published for the Society of Endocrinology by the Journal of Endocrinology Ltd., 1994-
    • Subject Terms:
      Thyroid Neoplasms*/pathology ; Thyroid Neoplasms*/diagnosis ; Thyroid Neoplasms*/metabolism ; Thyroglobulin*/metabolism ; Thyroglobulin*/blood; Humans ; Female ; Male ; Biopsy, Fine-Needle ; Middle Aged ; Retrospective Studies ; Adult ; Aged ; Lymphatic Metastasis ; Thyroid Cancer, Papillary/pathology ; Thyroid Cancer, Papillary/diagnosis ; Thyroid Cancer, Papillary/blood ; Thyroid Cancer, Papillary/metabolism ; Young Adult
    • Abstract:
      Measurement of thyroglobulin in fine-needle aspirates (FNA-Tg) is useful for the diagnosis of lymph node metastasis in thyroid carcinoma; however, the cutoff value remains unclear, particularly for the differential diagnosis of neck masses. To evaluate the cutoff value of FNA-Tg, we conducted a retrospective study of patients with neck masses outside the thyroid who pre-operatively underwent both FNAC and FNA-Tg, followed by pathological examination at our hospital from October 2015 to September 2020. The cutoff value of FNA-Tg was calculated using the receiver operating characteristic curve. Among 210 lesions, 57 were of thyroid origin and 153 lesions were not of thyroid origin. A high FNA-Tg value was observed in the lesions of thyroid origin (P: 0.001), and the cutoff value at the minimum point of 100% specificity was 32.2 ng/mL with a sensitivity of 87.7%. Regarding the effect of serum anti-Tg antibodies, FNA-Tg values were significantly lower or not significantly different depending on the grouping, warranting further studies. Among the cases with papillary thyroid carcinoma, the sensitivity of FNAC and FNA-Tg was 71.4% and 87.5%, respectively. The cutoff value of FNA-Tg for the differential diagnosis of neck masses was higher compared to previous reports because some metastatic lymph nodes of carcinomas and lesions, other than lymph nodes, exhibited higher FNA-Tg values. Therefore, if FNA-Tg is to be used as a screening test for the differential diagnosis of neck masses in patients without proven thyroid carcinoma, it is necessary to establish a higher cutoff value.
    • Contributed Indexing:
      Keywords: cutoff value; differential diagnosis of neck masses; lesions other than the lymph nodes; thyroglobulin in fine-needle aspirates
    • Accession Number:
      9010-34-8 (Thyroglobulin)
    • Publication Date:
      Date Created: 20240926 Date Completed: 20241030 Latest Revision: 20241105
    • Publication Date:
      20241106
    • Accession Number:
      10.1530/ERC-24-0067
    • Accession Number:
      39326454