Postdischarge Mortality in a Cohort Hospitalized With Anorexia Nervosa.

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  • Additional Information
    • Source:
      Publisher: Wiley Country of Publication: United States NLM ID: 8111226 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1098-108X (Electronic) Linking ISSN: 02763478 NLM ISO Abbreviation: Int J Eat Disord Subsets: MEDLINE
    • Publication Information:
      Publication: <2005-> : Hoboken, NJ : Wiley
      Original Publication: [New York, N.Y. : Van Nostrand Reinhold Co., c1981-
    • Subject Terms:
      Anorexia Nervosa*/mortality ; Patient Discharge* ; Hospitalization*/statistics & numerical data; Humans ; Female ; Male ; Adult ; Canada/epidemiology ; Cohort Studies ; Young Adult ; Adolescent ; Middle Aged ; Cause of Death
    • Abstract:
      Objective: To characterize mortality after hospital discharge in cohorts with and without anorexia nervosa (AN).
      Methods: We obtained data for all hospitalizations for psychiatric reasons in Canada (except Quebec) between April 1, 2006, and March 31, 2021 (n = 1.3 million admissions). Cases of AN were identified using ICD-10 (F50.0 and F50.1) codes. First admissions during this interval for AN and other psychiatric conditions were linked to vital statistics data. Mortality was characterized through cross-tabulation, Cox proportional hazards models, and competing cause regression.
      Results: After adjustment for age and sex, there was no significant difference in mortality between AN and those with other psychiatric conditions (HR = 1.04; p = 0.644). Among AN admissions, 25% (95% CI 18.6-31.4) of deaths were attributed to psychiatric conditions (ICD-F codes), with 88% of these (comprising 22% of all deaths in the AN group) having AN itself identified as the underlying cause of death. In contrast, only 8% of deaths among non-AN admissions were attributed to a mental disorder.
      Discussion: Prevention of premature mortality in the general psychiatric population emphasizes modification of metabolic (e.g., hyperlipidemia) and lifestyle-related (e.g., sedentary behavior) risk factors. However, as AN itself makes a major contribution to mortality, specialized preventive strategies may be required.
      (© 2024 The Author(s). International Journal of Eating Disorders published by Wiley Periodicals LLC.)
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    • Grant Information:
      Cumming School of Medicine; University of Calgary
    • Contributed Indexing:
      Keywords: anorexia nervosa; cause of death; feeding and eating disorders; mortality
    • Publication Date:
      Date Created: 20240926 Date Completed: 20241210 Latest Revision: 20241212
    • Publication Date:
      20241212
    • Accession Number:
      PMC11629045
    • Accession Number:
      10.1002/eat.24296
    • Accession Number:
      39324368