Discovery of metabolite from the insect-derived endophytic Penicillium chrysogenum and their COX-2 inhibitory activity.

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  • Additional Information
    • Source:
      Publisher: Elsevier Country of Publication: Netherlands NLM ID: 16930290R Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-6971 (Electronic) Linking ISSN: 0367326X NLM ISO Abbreviation: Fitoterapia Subsets: MEDLINE
    • Publication Information:
      Publication: 1999- : [Amsterdam] : Elsevier
      Original Publication: Milano : Inverni & Della Beffa S.p.A.
    • Subject Terms:
      Penicillium chrysogenum* ; Cyclooxygenase 2 Inhibitors*/isolation & purification ; Cyclooxygenase 2 Inhibitors*/pharmacology; Animals ; Molecular Structure ; Periplaneta/microbiology ; Endophytes/chemistry ; China ; Benzamides/pharmacology ; Benzamides/isolation & purification
    • Abstract:
      Three new N-alkylated amino acid derivatives, penichrysoamides A-C (1-3), along with a new citric acid derivative, penichrysoacid A (4), a new chromanone lactone penichrysoacid B (5), and a new amide derivative, penichrysoamide D (6), as well as seven known benzamide derivatives (7-13), were isolated from the endophytic fungus Penicillium chrysogenum derived from the insect Periplaneta americana. The structures of these compounds, including their absolute configurations, were elucidated using spectroscopic and computational techniques. Biological evaluation revealed that compounds 8-13 exhibited significant COX-2 inhibitory activity, with IC 50 values ranging from 275 nM to 1350 nM.
      Competing Interests: Declaration of competing interest The authors declare no conflicts of interest.
      (Copyright © 2024 Elsevier B.V. All rights reserved.)
    • Contributed Indexing:
      Keywords: COX-2; Metabolites; Penicillium chrysogenum; Periplaneta americana
    • Accession Number:
      0 (Cyclooxygenase 2 Inhibitors)
      0 (Benzamides)
    • Publication Date:
      Date Created: 20240925 Date Completed: 20241111 Latest Revision: 20241111
    • Publication Date:
      20241114
    • Accession Number:
      10.1016/j.fitote.2024.106238
    • Accession Number:
      39321858