Microbial transformation of dietary xenobiotics shapes gut microbiome composition.

Publisher: Cell Press Country of Publication: United States NLM ID: 0413066 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1097-4172 (Electronic) Linking ISSN: 00928674 NLM ISO Abbreviation: Cell Subsets: MEDLINE

Publication: Cambridge, Ma : Cell Press
Original Publication: Cambridge, MIT Press.

Xenobiotics*/metabolism ; Gastrointestinal Microbiome* ; Resveratrol*/metabolism ; Diet*; Humans ; Stilbenes/metabolism ; Male ; Female ; Inactivation, Metabolic ; Bacteria/metabolism ; Bacteria/classification ; Bacteria/genetics

Diet is a major determinant of gut microbiome composition, and variation in diet-microbiome interactions may contribute to variation in their health consequences. To mechanistically understand these relationships, here we map interactions between ∼150 small-molecule dietary xenobiotics and the gut microbiome, including the impacts of these compounds on community composition, the metabolic activities of human gut microbes on dietary xenobiotics, and interindividual variation in these traits. Microbial metabolism can toxify and detoxify these compounds, producing emergent interactions that explain community-specific remodeling by dietary xenobiotics. We identify the gene and enzyme responsible for detoxification of one such dietary xenobiotic, resveratrol, and demonstrate that this enzyme contributes to interindividual variation in community remodeling by resveratrol. Together, these results systematically map interactions between dietary xenobiotics and the gut microbiome and connect toxification and detoxification to interpersonal differences in microbiome response to diet.
Competing Interests: Declaration of interests A.L.G. serves on the scientific advisory boards of Seres Therapeutics, Taconic Biosciences, and Piton Therapeutics.
(Copyright © 2024 Elsevier Inc. All rights reserved.)

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R01 AT010014 United States AT NCCIH NIH HHS; R01 DK133798 United States DK NIDDK NIH HHS; R35 GM118159 United States GM NIGMS NIH HHS; T32 GM148332 United States GM NIGMS NIH HHS

Keywords: community composition; dietary xenobiotics; emergent interactions; gnotobiotics; microbial metabolism; microbiome

0 (Xenobiotics)
Q369O8926L (Resveratrol)
0 (Stilbenes)

Date Created: 20240925 Date Completed: 20241101 Latest Revision: 20241108

20241108

PMC11531382

10.1016/j.cell.2024.08.038

39321800