Perioperative Change of High-Sensitive Cardiac Troponin I Concentration in Cats According to Three Different Anaesthesia Protocols.

Item request has been placed! ×
Item request cannot be made. ×
loading   Processing Request
Read More Add to Saved list
  • Additional Information
    • Source:
      Publisher: John Wiley & Sons Ltd Country of Publication: England NLM ID: 101678837 Publication Model: Print Cited Medium: Internet ISSN: 2053-1095 (Electronic) Linking ISSN: 20531095 NLM ISO Abbreviation: Vet Med Sci Subsets: MEDLINE
    • Publication Information:
      Original Publication: [Oxford] : John Wiley & Sons Ltd., [2015]-
    • Subject Terms:
      Troponin I*/blood ; Xylazine*/administration & dosage ; Ketamine*/administration & dosage ; Propofol*/administration & dosage ; Isoflurane*/administration & dosage; Animals ; Cats/surgery ; Female ; Hysterectomy/veterinary ; Ovariectomy/veterinary ; Perioperative Period/veterinary ; Anesthetics, Inhalation/administration & dosage ; Anesthesia/veterinary ; Anesthetics, Intravenous/administration & dosage ; Anesthetics, Intravenous/pharmacology ; Anesthesia, General/veterinary
    • Abstract:
      Background: Cardiac troponin I, a particular biomarker, is released into the bloodstream in response to myocardial injury.
      Objectives: To evaluate perioperative changes in high-sensitivity cardiac troponin I (hs-cTnI) concentration during ovariohysterectomy in cats undergoing three different anaesthesia protocols.
      Methods:  Twenty-one female mixed-breed cats owned by clients aged (2.2 ± 0.7 years) and weight (3.2 ± 0.5 kg) were included in our study. The cats were divided into three groups: propofol-isoflurane (PI) group (n = 7), xylazine-ketamine (XK) group (n = 7) and xylazine-isoflurane (XI) group (n = 7). After pre-anaesthetic propofol (6 mg/kg IV) was administered to cats in Group PI, a mask was placed, and anaesthesia was maintained with 3.0% isoflurane in oxygen. Cats in Group XK underwent general anesthetization with xylazine hydrochloride (2 mg/kg IM) and, 10 min later, ketamine hydrochloride (10 mg/kg IM). Cats in Group XI were administered xylazine hydrochloride (2 mg/kg IM), and then anaesthesia (3.0% isoflurane and oxygen) was continued with a mask. Blood samples were collected from all cats; preoperatively and postoperatively at 0 and 12 h (Pre-, Post-0 h and Post-12 h, respectively). Serum hs-cTnI concentrations were measured with the Advia Centaur TnI-Ultra.
      Results: In all 21 cats, hs-cTnI concentration increased at Post-0 h and 12 h measurement points compared to Pre-. In the XK group, hs-cTnI concentrations exhibited a significant increase at the Post-0 h (51.30 ng/L) and Post-12 h (157.70 ng/L) time points compared to Pre- (6.70 ng/L) (p < 0.05).
      Conclusions: The XK group increased the concentration of hs-cTnI more than other protocols. In the PI group, the increase in hs-cTnI concentrations at Post-0 and 12 h increased less than the other two groups (p < 0.05). The PI group was found to induce less myocardial damage.
      (© None The Author(s). Veterinary Medicine and Science published by John Wiley & Sons Ltd.)
    • References:
      J S Afr Vet Assoc. 1996 Dec;67(4):188-98. (PMID: 9284030)
      Vet Anaesth Analg. 2010 Sep;37(5):409-16. (PMID: 20712607)
      Am J Clin Pathol. 2007 Jul;128(1):164-7. (PMID: 17580285)
      Vet Q. 1992;14(3):91-4. (PMID: 1413446)
      J Vet Med Sci. 2021 Dec 2;83(12):1869-1876. (PMID: 34629333)
      Exp Anim. 2020 Jan 29;69(1):54-61. (PMID: 31462610)
      J Vet Intern Med. 2008 Sep-Oct;22(5):1136-43. (PMID: 18638021)
      Vet Clin Pathol. 2013 Dec;42(4):490-8. (PMID: 24131244)
      JAMA. 2017 Apr 25;317(16):1642-1651. (PMID: 28444280)
      Vet Med (Praha). 2022 Feb 14;67(4):199-205. (PMID: 39170806)
      Am Heart J. 2008 Feb;155(2):208-14. (PMID: 18215588)
      J Vet Cardiol. 2014 Jun;16(2):81-9. (PMID: 24834862)
      Ann Clin Biochem. 2001 Jan;38(Pt 1):61-3. (PMID: 11270845)
      Anesthesiology. 1991 Mar;74(3):581-605. (PMID: 1672060)
      PLoS One. 2023 Jul 18;18(7):e0288801. (PMID: 37463140)
      Circulation. 2018 Mar 20;137(12):1221-1232. (PMID: 29203498)
      J Am Vet Med Assoc. 2016 Apr 15;248(8):923-8. (PMID: 27031419)
      Front Vet Sci. 2022 Oct 04;9:1008765. (PMID: 36268044)
      J Am Vet Med Assoc. 2022 Feb 16;260(8):1-9. (PMID: 35175929)
      Res Vet Sci. 2013 Jun;94(3):446-8. (PMID: 23178045)
      J Am Vet Med Assoc. 2012 Feb 15;240(4):404-12. (PMID: 22309012)
      J Vet Intern Med. 2004 Nov-Dec;18(6):831-9. (PMID: 15638266)
      J Emerg Med. 2002 Jul;23(1):57-65. (PMID: 12217473)
      Circulation. 2021 Nov 9;144(19):e287-e305. (PMID: 34601955)
      Can Vet J. 2004 Jun;45(6):475-80. (PMID: 15283516)
      J Vet Intern Med. 2016 Jan-Feb;30(1):36-50. (PMID: 26681537)
      J Small Anim Pract. 2014 Jun;55(6):320-2. (PMID: 24645736)
      Res Vet Sci. 2008 Aug;85(1):141-4. (PMID: 17961616)
      J Pharmacol Exp Ther. 1992 Nov;263(2):690-7. (PMID: 1359110)
      Vet Clin Pathol. 2012 Sep;41(3):375-81. (PMID: 22747688)
      Vet Anaesth Analg. 2009 Sep;36(5):449-56. (PMID: 19709049)
      Vet Anaesth Analg. 2006 Jul;33(4):214-23. (PMID: 16764585)
      Aust Vet J. 2008 Oct;86(10):390-4. (PMID: 18826510)
      Indian J Clin Biochem. 2007 Mar;22(1):10-7. (PMID: 23105645)
      J Vet Intern Med. 2002 Jan-Feb;16(1):63-8. (PMID: 11822806)
      Vet Anaesth Analg. 2012 May;39(3):236-44. (PMID: 22405473)
      Vet Anaesth Analg. 2018 Nov;45(6):745-753. (PMID: 30309716)
    • Contributed Indexing:
      Keywords: cardiac troponin I; cat; isoflurane; ketamine hydrochloride; propofol; xylazine hydrochloride
    • Accession Number:
      0 (Troponin I)
      2KFG9TP5V8 (Xylazine)
      690G0D6V8H (Ketamine)
      YI7VU623SF (Propofol)
      CYS9AKD70P (Isoflurane)
      0 (Anesthetics, Inhalation)
      0 (Anesthetics, Intravenous)
    • Publication Date:
      Date Created: 20240925 Date Completed: 20240925 Latest Revision: 20240927
    • Publication Date:
      20240927
    • Accession Number:
      PMC11423905
    • Accession Number:
      10.1002/vms3.70050
    • Accession Number:
      39321206