Live birth rate after oocyte donation in females diagnosed with turner syndrome: a systematic review and meta-analysis.

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  • Additional Information
    • Source:
      Publisher: BioMed Central Country of Publication: England NLM ID: 100967799 Publication Model: Electronic Cited Medium: Internet ISSN: 1471-2393 (Electronic) Linking ISSN: 14712393 NLM ISO Abbreviation: BMC Pregnancy Childbirth Subsets: MEDLINE
    • Publication Information:
      Original Publication: London : BioMed Central, [2001-
    • Subject Terms:
      Birth Rate* ; Fertilization in Vitro*/methods ; Fertilization in Vitro*/statistics & numerical data ; Infertility, Female*/etiology ; Infertility, Female*/therapy ; Live Birth*/epidemiology ; Oocyte Donation* ; Turner Syndrome*/complications; Female ; Humans ; Pregnancy ; Embryo Transfer/statistics & numerical data ; Embryo Transfer/methods ; Pregnancy Outcome/epidemiology ; Pregnancy Rate
    • Abstract:
      Background: An enduring challenge for women diagnosed with Turner syndrome (TS) is infertility. Oocyte donation (OD) offers a chance of pregnancy for these patients. However, current data on pregnancy outcomes are inadequate. Hence, this systematic review aims to explore the clinical outcomes of OD in patients with TS.
      Methods: A systematic search was conducted in PubMed, Web of Sciences, Scopus, and Embase for relevant papers from 1 January 1990 to 30 November 2023. Our primary research objective is to determine the live birth rate among women with TS who have undergone in vitro fertilization (IVF) using OD for fertility purposes. Specifically, we aim to calculate the pooled live birth rates per patient and per embryo transfer (ET) cycle. For secondary outcomes, we have analyzed the rates of clinical pregnancy achievement per ET cycle and the incidence of gestational hypertensive complications per clinical pregnancy. Prevalence meta-analyses were performed using STATA 18.0 by utilizing a random-effects model and calculating the pooled rates of each outcome using a 95% confidence interval (CI).
      Results: A total of 14 studies encompassing 417 patients were systematically reviewed. Except for one prospective clinical trial and one prospective cohort study, all other 12 studies had a retrospective cohort design. Our meta-analysis has yielded a pooled live birth rate per patient of 40% (95% CI: 29-51%; 14 studies included) and a pooled live birth rate per ET cycle of 17% (95% CI: 13-20%; 13 studies included). Also, the pooled clinical pregnancy achievement rate per ET cycle was estimated at 31% (95% CI: 25-36%; 12 studies included). Moreover, the pooled rate of pregnancy-induced hypertensive disorders per clinical pregnancy was estimated at 12% (95% CI: 1-31%; 8 studies included). No publication bias was found across all analyses.
      Conclusions: This study demonstrated promising pregnancy outcomes for OD in patients with TS. Further studies are essential to address not only the preferred techniques, but also the psychological, ethical, and societal implications of these complex procedures for these vulnerable populations.
      Trial Registration: This systematic review was registered in the International Prospective Register of Systematic Reviews (PROSPERO) under the registration code CRD42023494273.
      (© 2024. The Author(s).)
    • References:
      Hum Reprod. 1990 Apr;5(3):291-3. (PMID: 2351712)
      Fertil Steril. 1997 Apr;67(4):717-23. (PMID: 9093200)
      Child Adolesc Psychiatr Clin N Am. 2007 Jul;16(3):709-22. (PMID: 17562588)
      Hum Reprod. 2011 Oct;26(10):2754-62. (PMID: 21835831)
      Eur J Obstet Gynecol Reprod Biol. 2019 Jul;238:73-77. (PMID: 31121341)
      Hum Reprod. 1997 Feb;12(2):279-85. (PMID: 9070711)
      Fertil Steril. 2019 Aug;112(2):220-225. (PMID: 31352961)
      J Matern Fetal Neonatal Med. 2011 May;24(5):668-72. (PMID: 20923275)
      J Clin Endocrinol Metab. 2009 Jan;94(1):74-80. (PMID: 18957497)
      Ann Endocrinol (Paris). 2022 Aug;83(4):244-249. (PMID: 35728697)
      Fertil Steril. 2010 Feb;93(2):379-81. (PMID: 19406398)
      Fertil Steril. 2011 Jun;95(7):2251-6. (PMID: 21496813)
      Biometrics. 1994 Dec;50(4):1088-101. (PMID: 7786990)
      BMJ. 2021 Mar 29;372:n71. (PMID: 33782057)
      Hum Fertil (Camb). 2021 Jul;24(3):169-181. (PMID: 30982353)
      Reprod Biol Endocrinol. 2015 Jun 10;13:59. (PMID: 26060131)
      Fertil Steril. 2012 Oct;98(4):780-6. (PMID: 22884020)
      Hum Reprod. 2016 Apr;31(4):782-8. (PMID: 26874361)
      Gynecol Obstet Fertil. 2008 Oct;36(10):1030-4. (PMID: 18815067)
      J Hum Reprod Sci. 2012 Sep;5(3):252-7. (PMID: 23531511)
      Am J Med Genet A. 2020 Feb;182(2):303-313. (PMID: 31854143)
      J Clin Epidemiol. 2012 Sep;65(9):934-9. (PMID: 22742910)
      Intractable Rare Dis Res. 2018 Nov;7(4):223-228. (PMID: 30560013)
      Fertil Steril. 1995 Nov;64(5):995-8. (PMID: 7589649)
      Eur J Endocrinol. 2017 Sep;177(3):G1-G70. (PMID: 28705803)
      Fertil Steril. 2020 Jul;114(1):144-154. (PMID: 32622407)
      Int J Mol Sci. 2023 Sep 11;24(18):. (PMID: 37762248)
      Int J Endocrinol. 2023 Feb 16;2023:6976389. (PMID: 36844105)
      J Clin Endocrinol Metab. 2023 Nov 17;108(12):e1649-e1659. (PMID: 37296515)
      Prenat Diagn. 2023 Feb;43(2):261-271. (PMID: 36336873)
      Fertil Steril. 2012 Oct;98(4):775-9. (PMID: 23020909)
      J Obstet Gynaecol Can. 2016 Aug;38(8):712-8. (PMID: 27638981)
      Hum Reprod. 1999 Feb;14(2):532-5. (PMID: 10100005)
      Gynecol Obstet Fertil. 2002 Dec;30(12):970-8. (PMID: 12661287)
      Hum Reprod. 2011 Aug;26(8):2061-8. (PMID: 21646279)
      J Clin Endocrinol Metab. 2002 Aug;87(8):3618-23. (PMID: 12161485)
      Ultrasound Obstet Gynecol. 2018 Jan;51(1):7-9. (PMID: 29297613)
      BMJ. 1997 Sep 13;315(7109):629-34. (PMID: 9310563)
      Fertil Steril. 1996 Jun;65(6):1249-52. (PMID: 8641509)
      Obstet Gynecol Surv. 2020 Sep;75(9):566-575. (PMID: 32997149)
      J Clin Endocrinol Metab. 2011 Feb;96(2):E260-7. (PMID: 21147890)
      Fertil Steril. 1999 Jan;71(1):15-21. (PMID: 9935110)
      Fertil Steril. 2020 Aug;114(2):346-353. (PMID: 32680612)
      Fertil Steril. 2018 Nov;110(6):988-993. (PMID: 30396566)
      Fertil Steril. 2003 Sep;80(3):498-501. (PMID: 12969688)
      Cells. 2023 May 11;12(10):. (PMID: 37408200)
      Front Med (Lausanne). 2020 Jan 24;7:3. (PMID: 32039223)
      Fertil Steril. 2009 Apr;91(4 Suppl):1489-92. (PMID: 18793776)
      Ann N Y Acad Sci. 1997 Jun 17;816:389-94. (PMID: 9238293)
      J Hum Hypertens. 2023 Aug;37(8):675-688. (PMID: 36471031)
      J Clin Endocrinol Metab. 2001 Jul;86(7):3061-9. (PMID: 11443168)
      Hum Reprod. 2023 Sep 5;38(9):1733-1745. (PMID: 37381072)
      Curr Opin Endocrinol Diabetes Obes. 2023 Feb 1;30(1):16-26. (PMID: 36437755)
      Int J Fertil Steril. 2014 Oct;8(3):289-98. (PMID: 25379158)
      Hum Reprod. 2006 Mar;21(3):829-32. (PMID: 16311294)
      Fertil Steril. 2011 Jun 30;95(8):2507-10. (PMID: 21256486)
      BMJ. 2011 Jul 22;343:d4002. (PMID: 21784880)
    • Contributed Indexing:
      Keywords: Assisted reproductive techniques; Embryo transfer; Live birth; Oocyte donation; Turner syndrome
    • Publication Date:
      Date Created: 20240918 Date Completed: 20240919 Latest Revision: 20241009
    • Publication Date:
      20241009
    • Accession Number:
      PMC11411911
    • Accession Number:
      10.1186/s12884-024-06801-8
    • Accession Number:
      39294592