Vasorelaxant and tracheorelaxant effects of Bocconia arborea and their isolated benzophenanthridine alkaloids.

Publisher: Elsevier Country of Publication: Netherlands NLM ID: 16930290R Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-6971 (Electronic) Linking ISSN: 0367326X NLM ISO Abbreviation: Fitoterapia Subsets: MEDLINE

Publication: 1999- : [Amsterdam] : Elsevier
Original Publication: Milano : Inverni & Della Beffa S.p.A.

Vasodilator Agents*/pharmacology ; Vasodilator Agents*/isolation & purification ; Plant Bark*/chemistry ; Benzophenanthridines*/pharmacology ; Benzophenanthridines*/isolation & purification ; Benzophenanthridines*/chemistry ; Alkaloids*/pharmacology ; Alkaloids*/isolation & purification ; Trachea*/drug effects ; Papaveraceae*/chemistry ; Plant Extracts*/pharmacology ; Plant Extracts*/chemistry; Animals ; Rats ; Male ; Molecular Structure ; Mexico ; Isoquinolines/pharmacology ; Isoquinolines/isolation & purification ; Rats, Wistar ; Phytochemicals/pharmacology ; Phytochemicals/isolation & purification ; Aorta/drug effects ; Plants, Medicinal/chemistry

Bocconia arborea S. Watson (Papaveraceae) is an abundant medicinal plant in the North of Morelos State, Mexico, which is used for the treatment of several diseases. The aim of current investigation was to isolate the compounds responsible of the relaxant effect shown by the active extracts. Thus, phytochemical bio-guided fractionation allowed the isolation of angoline (1), dihydrosanguinarine (2), bocconarborine A (3), oxisanguinarine (4), and oxychelerithrine (5) from dichloromethanic and methanolic extracts from the bark of Bocconia arborea (Papaveraceae). The relaxant study on aortic and tracheal rat rings of all benzophenanthridines indicates that 1 was the most active compound of the entire series investigated. Angoline (1) induces its relaxant effect by a concentration-dependent manner through the calcium channel blockade in both tissues.
Competing Interests: Declaration of competing interest The authors declare no conflict of interest.
(Copyright © 2024 Elsevier B.V. All rights reserved.)

Keywords: Angoline; Benzophenathridines; Bocconia arborea; Calcium channel; Relaxant effect

0 (Vasodilator Agents)
0 (Benzophenanthridines)
0 (Alkaloids)
0 (Plant Extracts)
0 (Isoquinolines)
0 (Phytochemicals)
3H1ZKG80F7 (dihydrosanguinarine)

Date Created: 20240915 Date Completed: 20241111 Latest Revision: 20241111

20241114

10.1016/j.fitote.2024.106212

39278422