Elevated serum levels of C-terminal agrin fragment in acetylcholine receptor antibody-positive myasthenia gravis.

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  • Additional Information
    • Source:
      Publisher: Elsevier/North-Holland Country of Publication: Netherlands NLM ID: 8109498 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1872-8421 (Electronic) Linking ISSN: 01655728 NLM ISO Abbreviation: J Neuroimmunol Subsets: MEDLINE
    • Publication Information:
      Original Publication: [Amsterdam] : Elsevier/North-Holland, c1981-
    • Subject Terms:
      Agrin*/blood ; Agrin*/immunology ; Myasthenia Gravis*/blood ; Myasthenia Gravis*/immunology ; Receptors, Cholinergic*/immunology ; Autoantibodies*/blood ; Autoantibodies*/immunology ; Peptide Fragments*/blood ; Peptide Fragments*/immunology; Humans ; Female ; Male ; Middle Aged ; Adult ; Aged ; Biomarkers/blood ; Young Adult
    • Abstract:
      Agrin is essential for neuromuscular junction (NMJ) formation and maintenance. The C-terminal agrin fragment (CAF), generated by neurotrypsin-mediated cleavage of agrin, has been gaining attention as a potential biomarker for sarcopenia. We investigated serum CAF levels in myasthenia gravis (MG), a NMJ disorder. Compared to healthy controls, serum CAF levels were significantly elevated in acetylcholine receptor antibody-positive MG (AChR-MG) patients, but not in muscle-specific kinase antibody-positive MG patients. In AChR-MG, baseline and post-treatment CAF levels inversely correlated with post-treatment MG activities of daily living scores, suggesting that elevated CAF levels may reflect protective mechanisms against AChR-MG pathogenesis, such as improved NMJ regeneration.
      Competing Interests: Declaration of competing interest A. Uzawa received honoraria from UCB, Alexion Pharmaceuticals, and Argenx.
      (Copyright © 2024 The Authors. Published by Elsevier B.V. All rights reserved.)
    • Contributed Indexing:
      Keywords: Agrin; C-terminal agrin fragment; Myasthenia gravis; Neuromuscular junction; Sarcopenia
    • Accession Number:
      0 (Agrin)
      0 (Receptors, Cholinergic)
      0 (Autoantibodies)
      0 (Peptide Fragments)
      0 (C-terminal agrin fragment)
      0 (Biomarkers)
    • Publication Date:
      Date Created: 20240914 Date Completed: 20241110 Latest Revision: 20241110
    • Publication Date:
      20241114
    • Accession Number:
      10.1016/j.jneuroim.2024.578455
    • Accession Number:
      39276618