Novel Magnesium- and Silver-Loaded Dressing Promotes Tissue Regeneration in Cutaneous Wounds.

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  • Additional Information
    • Source:
      Publisher: MDPI Country of Publication: Switzerland NLM ID: 101092791 Publication Model: Electronic Cited Medium: Internet ISSN: 1422-0067 (Electronic) Linking ISSN: 14220067 NLM ISO Abbreviation: Int J Mol Sci Subsets: MEDLINE
    • Publication Information:
      Original Publication: Basel, Switzerland : MDPI, [2000-
    • Subject Terms:
      Wound Healing*/drug effects ; Magnesium*/pharmacology ; Silver*/chemistry ; Silver*/pharmacology ; Bandages*; Humans ; Animals ; Cell Proliferation/drug effects ; Skin/drug effects ; Skin/metabolism ; Skin/injuries ; Cell Movement/drug effects ; Regeneration/drug effects ; Male ; Anti-Bacterial Agents/pharmacology ; Fibroblasts/drug effects ; Fibroblasts/metabolism ; Mice ; Neovascularization, Physiologic/drug effects
    • Abstract:
      Wound healing is a dynamic process involving a complex interaction between many cells and mediators. Magnesium (Mg) is an essential element for cell stabilization. Mg was reported to stimulate the proliferation and migration of endothelial cells in angiogenesis in vitro. However, the function of Mg in wound healing is not known. We observed that the expression level of Mg in human wound tissue fluid was only 10% of that found in human blood serum. To confirm whether Mg is a suitable wound dressing material, we fabricated a Mg- or Mg-silver (Ag)-based polyethylene dressing to study its effect on wound healing. We observed that Mg and Ag were stably preserved in the constructed material and were able to be rapidly released in the moist environment. We also observed that the Mg-based dressing had good cellular compatibility without harmful extractables. Furthermore, Mg enhanced the antibacterial activity of Ag. In line with the observed increase in fibroblast migration in vitro, the Mg-Ag-based dressing improved acute and chronic wound repairs via an increase in neovascularization and basal cell proliferation. The present results show that a Mg-Ag-based coating can be manufactured as an optimal dressing for adjuvant wound therapy.
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    • Contributed Indexing:
      Keywords: magnesium; silver; wound dressing; wound healing
    • Accession Number:
      I38ZP9992A (Magnesium)
      3M4G523W1G (Silver)
      0 (Anti-Bacterial Agents)
    • Publication Date:
      Date Created: 20240914 Date Completed: 20240914 Latest Revision: 20240916
    • Publication Date:
      20240916
    • Accession Number:
      PMC11395027
    • Accession Number:
      10.3390/ijms25179311
    • Accession Number:
      39273259