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Essential Roles of PIEZO1 in Mammalian Cardiovascular System: From Development to Diseases.
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- Additional Information
- Source:
Publisher: MDPI Country of Publication: Switzerland NLM ID: 101600052 Publication Model: Electronic Cited Medium: Internet ISSN: 2073-4409 (Electronic) Linking ISSN: 20734409 NLM ISO Abbreviation: Cells Subsets: MEDLINE
- Publication Information:
Original Publication: Basel, Switzerland : MDPI
- Subject Terms:
- Abstract:
Mechanical force is the basis of cardiovascular development, homeostasis, and diseases. The perception and response of mechanical force by the cardiovascular system are crucial. However, the molecular mechanisms mediating mechanotransduction in the cardiovascular system are not yet understood. PIEZO1, a novel transmembrane mechanosensitive cation channel known for its regulation of touch sensation, has been found to be widely expressed in the mammalian cardiovascular system. In this review, we elucidate the role and mechanism of PIEZO1 as a mechanical sensor in cardiovascular development, homeostasis, and disease processes, including embryo survival, angiogenesis, cardiac development repair, vascular inflammation, lymphangiogenesis, blood pressure regulation, cardiac hypertrophy, cardiac fibrosis, ventricular remodeling, and heart failure. We further summarize chemical molecules targeting PIEZO1 for potential translational applications. Finally, we address the controversies surrounding emergent concepts and challenges in future applications.
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- Grant Information:
82270386 National Natural Science Foundation of China; 81670259 National Natural Science Foundation of China; 2023RC020 Zhejiang Provincial Medical and Health Technology Project
- Contributed Indexing:
Keywords: PIEZO1; cardiovascular system; chemical therapies; development; diseases; homeostasis; mechanotransduction
- Accession Number:
0 (Ion Channels)
0 (PIEZO1 protein, human)
- Publication Date:
Date Created: 20240914 Date Completed: 20240914 Latest Revision: 20241107
- Publication Date:
20241107
- Accession Number:
PMC11394449
- Accession Number:
10.3390/cells13171422
- Accession Number:
39272994
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