Essential Roles of PIEZO1 in Mammalian Cardiovascular System: From Development to Diseases.

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  • Additional Information
    • Source:
      Publisher: MDPI Country of Publication: Switzerland NLM ID: 101600052 Publication Model: Electronic Cited Medium: Internet ISSN: 2073-4409 (Electronic) Linking ISSN: 20734409 NLM ISO Abbreviation: Cells Subsets: MEDLINE
    • Publication Information:
      Original Publication: Basel, Switzerland : MDPI
    • Subject Terms:
    • Abstract:
      Mechanical force is the basis of cardiovascular development, homeostasis, and diseases. The perception and response of mechanical force by the cardiovascular system are crucial. However, the molecular mechanisms mediating mechanotransduction in the cardiovascular system are not yet understood. PIEZO1, a novel transmembrane mechanosensitive cation channel known for its regulation of touch sensation, has been found to be widely expressed in the mammalian cardiovascular system. In this review, we elucidate the role and mechanism of PIEZO1 as a mechanical sensor in cardiovascular development, homeostasis, and disease processes, including embryo survival, angiogenesis, cardiac development repair, vascular inflammation, lymphangiogenesis, blood pressure regulation, cardiac hypertrophy, cardiac fibrosis, ventricular remodeling, and heart failure. We further summarize chemical molecules targeting PIEZO1 for potential translational applications. Finally, we address the controversies surrounding emergent concepts and challenges in future applications.
    • References:
      PLoS Genet. 2019 Apr 18;15(4):e1008110. (PMID: 30998689)
      Annu Rev Biochem. 2021 Jun 20;90:507-534. (PMID: 34153212)
      Nat Commun. 2019 Mar 13;10(1):1200. (PMID: 30867417)
      Elife. 2018 Aug 22;7:. (PMID: 30132757)
      Am J Physiol Cell Physiol. 2019 Jan 1;316(1):C92-C103. (PMID: 30427721)
      Annu Rev Biomed Eng. 2021 Jul 13;23:1-27. (PMID: 34255994)
      Nat Commun. 2022 Jan 26;13(1):512. (PMID: 35082286)
      Hypertension. 2022 Mar;79(3):549-561. (PMID: 34983194)
      J Physiol. 2023 Dec 14;:. (PMID: 38098265)
      J Physiol. 2016 Feb 1;594(3):641-55. (PMID: 26608396)
      Biophys J. 2020 Oct 20;119(8):1683-1697. (PMID: 32949489)
      Br J Pharmacol. 2018 May;175(10):1744-1759. (PMID: 29498036)
      Curr Issues Mol Biol. 2023 Jul 13;45(7):5830-5848. (PMID: 37504285)
      Cell Rep. 2018 Apr 17;23(3):701-708. (PMID: 29669276)
      J Exp Med. 2018 Oct 1;215(10):2655-2672. (PMID: 30194266)
      Cell. 2021 Oct 28;184(22):5670-5685.e23. (PMID: 34637702)
      J Mol Cell Cardiol. 2020 Jun;143:51-62. (PMID: 32251670)
      Nat Commun. 2019 Oct 3;10(1):4503. (PMID: 31582801)
      Nature. 2018 Feb 22;554(7693):481-486. (PMID: 29261642)
      Cell. 2019 Oct 3;179(2):340-354. (PMID: 31585078)
      Hypertension. 2023 Aug;80(8):1598-1610. (PMID: 37259842)
      Front Pharmacol. 2020 May 25;11:768. (PMID: 32523536)
      Sci Signal. 2015 Feb 10;8(363):ra15. (PMID: 25670203)
      Nat Commun. 2018 Apr 3;9(1):1300. (PMID: 29610524)
      Am J Transl Res. 2017 Jun 15;9(6):2945-2955. (PMID: 28670382)
      Proc Natl Acad Sci U S A. 2014 Jul 15;111(28):10347-52. (PMID: 24958852)
      Cardiol J. 2016;23(5):556-562. (PMID: 27515482)
      Cells. 2022 Jul 13;11(14):. (PMID: 35883633)
      Circulation. 2018 Dec 18;138(25):2869-2880. (PMID: 30566020)
      Nat Cardiovasc Res. 2022 Jun;1(6):577-591. (PMID: 39195867)
      J Gen Physiol. 2020 Aug 3;152(8):. (PMID: 32582958)
      BMC Cardiovasc Disord. 2022 Jun 24;22(1):287. (PMID: 35751027)
      Am J Physiol Cell Physiol. 2021 Dec 1;321(6):C1010-C1027. (PMID: 34669509)
      Nat Commun. 2016 Jan 20;7:10366. (PMID: 26785635)
      Arterioscler Thromb Vasc Biol. 2019 Nov;39(11):2228-2239. (PMID: 31533470)
      J Neurointerv Surg. 2021 Jun;13(6):568-573. (PMID: 32848021)
      Cells. 2021 Apr 23;10(5):. (PMID: 33922466)
      Nature. 2014 Nov 13;515(7526):279-282. (PMID: 25119035)
      Br J Pharmacol. 2022 Jul;179(14):3778-3814. (PMID: 35194776)
      Hypertension. 2021 Jun;77(6):1974-1989. (PMID: 33813851)
      Trends Pharmacol Sci. 2019 Dec;40(12):956-970. (PMID: 31704174)
      Elife. 2020 Jun 02;9:. (PMID: 32484440)
      J Med Chem. 2022 May 12;65(9):6441-6453. (PMID: 35466678)
      Elife. 2015 May 22;4:. (PMID: 26001275)
      J Am Heart Assoc. 2014 Mar 10;3(2):e000626. (PMID: 24614757)
      Am J Physiol Lung Cell Mol Physiol. 2022 May 1;322(5):L737-L760. (PMID: 35318857)
      Biochem Pharmacol. 2019 Oct;168:473-480. (PMID: 31437459)
      Nat Commun. 2021 Feb 8;12(1):869. (PMID: 33558521)
      Curr Biol. 2014 May 19;24(10):R495-501. (PMID: 24845682)
      Inflamm Regen. 2019 Feb 7;39:3. (PMID: 30774738)
      Hum Cell. 2022 Jan;35(1):51-62. (PMID: 34606042)
      Cell Rep. 2020 Oct 6;33(1):108225. (PMID: 33027663)
      Chem Biol Interact. 2022 Aug 25;363:110011. (PMID: 35728671)
      Nature. 2012 Feb 19;483(7388):176-81. (PMID: 22343900)
      Nat Commun. 2017 Nov 27;8(1):1797. (PMID: 29176668)
      J Inflamm Res. 2021 Jul 27;14:3621-3636. (PMID: 34349540)
      J Mol Cell Cardiol. 2021 Sep;158:49-62. (PMID: 33974928)
      Proc Natl Acad Sci U S A. 2022 Jul 19;119(29):e2202269119. (PMID: 35858335)
      J Clin Invest. 2019 Jun 17;129(7):2775-2791. (PMID: 31205027)
      J Clin Invest. 2016 Sep 1;126(9):3313-35. (PMID: 27548520)
      Curr Top Membr. 2021;87:47-95. (PMID: 34696889)
      J Cell Commun Signal. 2020 Dec;14(4):357-376. (PMID: 32780323)
      Science. 2023 Aug 18;381(6659):799-804. (PMID: 37590348)
      Am J Physiol Cell Physiol. 2019 May 1;316(5):C741-C752. (PMID: 30811222)
      Cell Rep. 2016 Nov 8;17(7):1739-1746. (PMID: 27829145)
      J Immunol Res. 2019 Dec 1;2019:4354786. (PMID: 31886303)
      Clin Sci (Lond). 2020 Sep 18;134(17):2399-2418. (PMID: 32936305)
      Nat Commun. 2014 Mar 24;5:3520. (PMID: 24662763)
      Cell Rep. 2015 Nov 10;13(6):1161-1171. (PMID: 26526998)
      Science. 2010 Oct 1;330(6000):55-60. (PMID: 20813920)
      Cell Rep. 2022 Feb 8;38(6):110342. (PMID: 35139384)
      Cells. 2022 Jul 30;11(15):. (PMID: 35954193)
      Nat Commun. 2015 Sep 21;6:8329. (PMID: 26387913)
      Proc Natl Acad Sci U S A. 2016 Oct 11;113(41):11525-11530. (PMID: 27671657)
      Biophys J. 2017 Jan 10;112(1):31-45. (PMID: 28076814)
      ACS Nano. 2019 Nov 26;13(11):13545-13559. (PMID: 31689081)
      Nat Commun. 2017 Aug 24;8(1):350. (PMID: 28839146)
      Front Cardiovasc Med. 2022 Feb 17;9:842885. (PMID: 35252406)
      Biochim Biophys Acta Mol Basis Dis. 2017 Jun;1863(6):1326-1335. (PMID: 28366876)
      Biochemistry. 2011 Jul 26;50(29):6295-300. (PMID: 21696149)
      Nat Commun. 2018 May 23;9(1):2029. (PMID: 29795280)
      PLoS One. 2015 May 08;10(5):e0125503. (PMID: 25955826)
      Nature. 2018 Feb 22;554(7693):487-492. (PMID: 29469092)
      J Vasc Surg Venous Lymphat Disord. 2022 Mar;10(2):382-389.e2. (PMID: 34358671)
      Biochim Biophys Acta Mol Cell Biol Lipids. 2020 Oct;1865(10):158779. (PMID: 32739616)
      Mol Biol Cell. 2021 Aug 19;32(18):1724-1736. (PMID: 34081532)
      Cells. 2021 Mar 16;10(3):. (PMID: 33809739)
      Research (Wash D C). 2023 Jun 09;6:0165. (PMID: 37303604)
      Cells. 2021 Jul 09;10(7):. (PMID: 34359915)
      Curr Top Membr. 2017;79:37-57. (PMID: 28728823)
      Circ Res. 2016 Aug 5;119(4):519-31. (PMID: 27354212)
      Hypertension. 2021 Sep;78(3):647-660. (PMID: 34333987)
      Front Cell Dev Biol. 2022 Aug 19;10:933474. (PMID: 36081909)
      JACC Asia. 2023 Jul 04;3(4):622-624. (PMID: 37614532)
      Mil Med Res. 2023 Mar 10;10(1):12. (PMID: 36895064)
      Cells. 2022 Apr 02;11(7):. (PMID: 35406763)
      Sci Rep. 2018 Sep 24;8(1):14267. (PMID: 30250223)
      Aging (Albany NY). 2020 Dec 9;13(2):2231-2250. (PMID: 33318310)
      Nature. 1990 Nov 15;348(6298):261-3. (PMID: 1700306)
      Methods Enzymol. 2021;654:225-253. (PMID: 34120715)
      Hypertension. 2003 Apr;41(4):903-11. (PMID: 12642506)
      Nat Commun. 2015 Sep 03;6:8085. (PMID: 26333996)
      Cell Calcium. 2021 Jun 7;97:102431. (PMID: 34153657)
      Thromb Res. 2022 Oct;218:52-63. (PMID: 35988445)
      Sci Adv. 2022 Nov 11;8(45):eabo1461. (PMID: 36351022)
      J Biol Chem. 2019 Nov 15;294(46):17395-17408. (PMID: 31586031)
      Science. 2018 Oct 26;362(6413):464-467. (PMID: 30361375)
      J Clin Invest. 2016 Dec 1;126(12):4527-4536. (PMID: 27797339)
      Sci Transl Med. 2022 Mar 2;14(634):eabm4869. (PMID: 35235341)
      Commun Biol. 2019 Aug 7;2:298. (PMID: 31396578)
      Int J Mol Sci. 2022 Jul 22;23(15):. (PMID: 35897650)
      Int J Biol Sci. 2022 Jan 1;18(3):923-941. (PMID: 35173527)
      Circulation. 2020 Sep 15;142(11):1092-1105. (PMID: 32697107)
      Cells. 2020 Oct 22;9(11):. (PMID: 33105588)
      Arterioscler Thromb Vasc Biol. 2023 Apr;43(4):504-518. (PMID: 36756881)
    • Grant Information:
      82270386 National Natural Science Foundation of China; 81670259 National Natural Science Foundation of China; 2023RC020 Zhejiang Provincial Medical and Health Technology Project
    • Contributed Indexing:
      Keywords: PIEZO1; cardiovascular system; chemical therapies; development; diseases; homeostasis; mechanotransduction
    • Accession Number:
      0 (Ion Channels)
      0 (PIEZO1 protein, human)
    • Publication Date:
      Date Created: 20240914 Date Completed: 20240914 Latest Revision: 20241107
    • Publication Date:
      20241107
    • Accession Number:
      PMC11394449
    • Accession Number:
      10.3390/cells13171422
    • Accession Number:
      39272994