The diagnostic utility of the febrile agglutinin tests.

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  • Author(s): Zuerlein TJ; Smith PW
  • Source:
    JAMA [JAMA] 1985 Sep 06; Vol. 254 (9), pp. 1211-4.
  • Publication Type:
    Journal Article
  • Language:
    English
  • Additional Information
    • Source:
      Publisher: American Medical Association Country of Publication: United States NLM ID: 7501160 Publication Model: Print Cited Medium: Print ISSN: 0098-7484 (Print) Linking ISSN: 00987484 NLM ISO Abbreviation: JAMA Subsets: MEDLINE
    • Publication Information:
      Original Publication: Chicago : American Medical Association, 1960-
    • Subject Terms:
      Agglutination Tests*; Agglutinins/*analysis; Brucella abortus ; Brucellosis/diagnosis ; Cost-Benefit Analysis ; Evaluation Studies as Topic ; Humans ; Paratyphoid Fever/diagnosis ; Proteus Infections/diagnosis ; Retrospective Studies ; Salmonella Infections/diagnosis ; Salmonella enteritidis ; Tularemia/diagnosis ; Typhoid Fever/diagnosis
    • Abstract:
      The purpose of our study was to analyze the use of febrile agglutinin (FA) serologic tests in the diagnosis of Salmonella (typhi and paratyphi), Rickettsia, Brucella, and Francisella infections. Data were collected in a retrospective chart study of 202 titer requests covering a 42-month period at our teaching hospital. We found that no diagnoses were made by utilizing complete six-antigen FA panels. Three cases of infection were diagnosed serologically, all three with more discriminately selected single-antigen titers. These three cases each had a positive epidemiological history suggestive of disease prior to ordering FA tests. Our data suggest that the FA tests (especially the Salmonella group antigen) are an overutilized set of laboratory tests and are often difficult to interpret. It is much more important to make a diagnosis based on clinical findings and epidemiological criteria.
    • Accession Number:
      0 (Agglutinins)
    • Publication Date:
      Date Created: 19850906 Date Completed: 19850920 Latest Revision: 20161017
    • Publication Date:
      20250114
    • Accession Number:
      3927019