Structural MRI Correlates of Anosognosia in Huntington's Disease.

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  • Additional Information
    • Source:
      Publisher: IOS Press Country of Publication: Netherlands NLM ID: 101589965 Publication Model: Print Cited Medium: Internet ISSN: 1879-6400 (Electronic) Linking ISSN: 18796397 NLM ISO Abbreviation: J Huntingtons Dis Subsets: MEDLINE
    • Publication Information:
      Original Publication: Amsterdam, The Netherlands : IOS Press
    • Subject Terms:
      Huntington Disease*/diagnostic imaging ; Huntington Disease*/pathology ; Magnetic Resonance Imaging* ; Agnosia*/diagnostic imaging ; Agnosia*/etiology ; Agnosia*/pathology; Humans ; Male ; Female ; Middle Aged ; Adult ; Brain/diagnostic imaging ; Brain/pathology ; Globus Pallidus/diagnostic imaging ; Globus Pallidus/pathology
    • Abstract:
      Background: Anosognosia, or unawareness of symptoms, is common in Huntington's disease (HD), but the neuroanatomical basis of this is unknown.
      Objective: To identify neuroanatomical correlates of HD anosognosia using structural MRI data.
      Methods: We leveraged a pre-processed dataset of 570 HD participants across the well-characterized PREDICT-HD and TRACK-HD cohort studies. Anosognosia index was operationalized as the score discrepancies between HD participants and their caregivers on the Frontal Systems Behavior Scale (FrSBe).
      Results: Univariate correlation analyses identified volumes of globus pallidus, putamen, caudate, basal forebrain, substantia nigra, angular gyrus, and cingulate cortex as significant correlates of anosognosia after correction for multiple comparisons. A multivariable model constructed with stepwise regression that included volumetric data showed globus pallidus volume alone explained more variance in anosognosia severity than motor impairment or CAP score alone.
      Conclusions: Anosognosia appears to be related to degeneration affecting both cortical and subcortical areas. Globus pallidus neurodegeneration in particular appears to be a key process of importance.
    • Contributed Indexing:
      Keywords: Anosognosia; FrSBe; Huntington’s disease; PREDICT-HD; TRACK-HD; globus pallidus
    • Publication Date:
      Date Created: 20240913 Date Completed: 20240913 Latest Revision: 20240913
    • Publication Date:
      20240914
    • Accession Number:
      10.3233/JHD-240010
    • Accession Number:
      39269851