The actin cytoskeleton is important for pseudorabies virus infection.

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  • Additional Information
    • Source:
      Publisher: Academic Press Country of Publication: United States NLM ID: 0110674 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1096-0341 (Electronic) Linking ISSN: 00426822 NLM ISO Abbreviation: Virology Subsets: MEDLINE
    • Publication Information:
      Original Publication: New York, Academic Press.
    • Subject Terms:
      Herpesvirus 1, Suid*/physiology ; Herpesvirus 1, Suid*/genetics ; Herpesvirus 1, Suid*/metabolism ; Actin Cytoskeleton*/metabolism ; Virus Replication* ; Pseudorabies*/virology ; Pseudorabies*/metabolism; Animals ; Microfilament Proteins/metabolism ; Microfilament Proteins/genetics ; Swine ; Host-Pathogen Interactions ; Actins/metabolism ; Cell Line ; rho-Associated Kinases/metabolism ; Formins/metabolism ; Myosins/metabolism
    • Abstract:
      Viruses are dependent on the host factors for their replication and survival. Therefore, identification of host factors that druggable for antiviral development is crucial. The actin cytoskeleton plays an important role in the virus infection. The dynamics change of actin and its function are regulated by multiple actin-associated proteins (AAPs). However, the role and mechanism of various AAPs in the life cycle of virus are still enigmatic. In this study, we analyzed the roles of actin and AAPs in the replication of pseudorabies virus (PRV). Using a library of compounds targeting AAPs, our data found that multiple AAPs, such as Rho-GTPases, Rock, Myosin and Formin were involved in PRV infection. Besides, our result demonstrated that the actin-binding protein Drebrin was also participated in PRV infection. Further studies are necessary to elucidate the molecular mechanism of AAPs in the virus life cycle, in the hope of mining host factors for antiviral developments.
      Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
      (Copyright © 2024 Elsevier Inc. All rights reserved.)
    • Contributed Indexing:
      Keywords: Actin; Actin-associated protein; Cytoskeleton; Pseudorabies virus infection
    • Accession Number:
      0 (Microfilament Proteins)
      0 (Actins)
      EC 2.7.11.1 (rho-Associated Kinases)
      0 (Formins)
      EC 3.6.4.1 (Myosins)
    • Publication Date:
      Date Created: 20240910 Date Completed: 20241110 Latest Revision: 20241110
    • Publication Date:
      20241114
    • Accession Number:
      10.1016/j.virol.2024.110233
    • Accession Number:
      39255726