Investigation of P. vivax elimination via mass drug administration: A simulation study.

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  • Additional Information
    • Source:
      Publisher: Elsevier Country of Publication: Netherlands NLM ID: 101484711 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1878-0067 (Electronic) Linking ISSN: 18780067 NLM ISO Abbreviation: Epidemics Subsets: MEDLINE
    • Publication Information:
      Original Publication: Amsterdam : Elsevier
    • Subject Terms:
      Malaria, Vivax*/prevention & control ; Malaria, Vivax*/drug therapy ; Malaria, Vivax*/epidemiology ; Mass Drug Administration*/statistics & numerical data ; Plasmodium vivax*/drug effects ; Plasmodium vivax*/physiology ; Disease Eradication*/methods ; Disease Eradication*/statistics & numerical data ; Antimalarials*/therapeutic use ; Antimalarials*/administration & dosage; Humans ; Stochastic Processes ; Computer Simulation
    • Abstract:
      Plasmodium vivax is the most geographically widespread malaria parasite. P. vivax has the ability to remain dormant (as a hypnozoite) in the human liver and subsequently reactivate, which makes control efforts more difficult. Given the majority of P. vivax infections are due to hypnozoite reactivation, targeting the hypnozoite reservoir with a radical cure is crucial for achieving P. vivax elimination. Stochastic effects can strongly influence dynamics when disease prevalence is low or when the population size is small. Hence, it is important to account for this when modelling malaria elimination. We use a stochastic multiscale model of P. vivax transmission to study the impacts of multiple rounds of mass drug administration (MDA) with a radical cure, accounting for superinfection and hypnozoite dynamics. Our results indicate multiple rounds of MDA with a high-efficacy drug are needed to achieve a substantial probability of elimination. This work has the potential to help guide P. vivax elimination strategies by quantifying elimination probabilities for an MDA approach.
      Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
      (Copyright © 2024. Published by Elsevier B.V.)
    • Contributed Indexing:
      Keywords: Hypnozoite; Mass drug administration; P. vivax elimination; Relapse; Stochastic model
    • Accession Number:
      0 (Antimalarials)
    • Publication Date:
      Date Created: 20240910 Date Completed: 20240915 Latest Revision: 20240915
    • Publication Date:
      20240916
    • Accession Number:
      10.1016/j.epidem.2024.100789
    • Accession Number:
      39255654