Exploring alternative anthelmintic compounds: Impact of peruvin, hentriacontane/1-nonacosanol and their synergistic effect on the health of Meriones unguiculatus infected with Haemonchus contortus.

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  • Additional Information
    • Source:
      Publisher: Elsevier Country of Publication: Netherlands NLM ID: 7602745 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-2550 (Electronic) Linking ISSN: 03044017 NLM ISO Abbreviation: Vet Parasitol Subsets: MEDLINE
    • Publication Information:
      Publication: Amsterdam : Elsevier
      Original Publication: Amsterdam : Elsevier Scientific Pub. Co.
    • Subject Terms:
      Gerbillinae* ; Haemonchus*/drug effects ; Haemonchiasis*/veterinary ; Haemonchiasis*/drug therapy ; Haemonchiasis*/parasitology ; Anthelmintics*/pharmacology ; Anthelmintics*/therapeutic use ; Anthelmintics*/chemistry ; Anthelmintics*/administration & dosage ; Drug Synergism*; Animals ; Plant Extracts/pharmacology ; Plant Extracts/chemistry ; Plant Extracts/administration & dosage ; Larva/drug effects ; Artemisia/chemistry ; Male
    • Abstract:
      Haemonchus contortus is a highly pathogenic blood-feeding parasite affecting sheep and goats, leading to significant economic losses. With increasing resistance to conventional anthelmintics, exploring plant-based alternatives is crucial. In vitro, studies suggest that peruvin and hentriacontane/1-nonacosanol, isolated from Artemisia cina (Asteraceae), may synergistically control Haemonchus contortus. However, their in vivo efficacy and safety are unestablished. This study evaluated these compounds' anthelmintic activity and health effects and their synergistic mixture in Meriones unguiculatus (gerbils). The compounds were isolated using open-column chromatography and identified by spectroscopic techniques. Gerbils were artificially infected with H. contortus following dexamethasone treatment to enhance infection. Anthelmintic activity was assessed by larval reduction in the stomach, blood biochemical parameters using a blood chemistry analyzer, and the anatomopathological changes in kidney and liver tissues. Peruvin (0.4 mg/kg) and hentriacontane/1-nonacosanol (2.60 mg/kg) achieved larvicidal reductions of 84.86 % and 74.05 %, respectively, while their synergistic mixture (0.08/0.0017 mg/kg) resulted in a 100 % reduction. Histopathological analysis revealed minor inflammation and albuminous degeneration, primarily affecting the liver. The peruvin-treated group showed notable kidney damage, while hepatic alterations were similar across both compounds. Although effective, further research is needed to optimize dosing and ensure safety.
      Competing Interests: Declaration of Competing Interest The authors declare the following financial interests/personal relationships which may be considered as potential competing interests: Rosa Isabel Higuera-Piedrahita reports financial support was provided by Support Program for Research and Technological Innovation Projects (PAPIIT-UNAM) TA200324. Luis David Arango-De la Pava reports financial support was provided by National Autonomous University of Mexico Directorate General of Academic Staff Affairs. If there are other authors, they declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
      (Copyright © 2024. Published by Elsevier B.V.)
    • Contributed Indexing:
      Keywords: Anatomopathological changes; Anthelmintic; Binary mixture; Biochemical parameters; Haemonchus contortus; Hentriacontane/1-nonacosanol; Meriones unguiculatus; Peruvin
    • Accession Number:
      0 (Anthelmintics)
      0 (Plant Extracts)
    • Publication Date:
      Date Created: 20240907 Date Completed: 20241116 Latest Revision: 20241116
    • Publication Date:
      20241118
    • Accession Number:
      10.1016/j.vetpar.2024.110303
    • Accession Number:
      39243681