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Progesterone and estradiol alleviate Poly I:C-induced immune response in endometrial stromal cells.
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- Additional Information
- Source:
Publisher: Elsevier/North-Holland Biomedical Press Country of Publication: Ireland NLM ID: 8001906 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1872-7603 (Electronic) Linking ISSN: 01650378 NLM ISO Abbreviation: J Reprod Immunol Subsets: MEDLINE
- Publication Information:
Publication: Limerick : Elsevier/North-Holland Biomedical Press
Original Publication: Amsterdam, Elsevier/North-Holland Biomedical Press.
- Subject Terms:
- Abstract:
Progesterone (P) and estradiol (E 2 ) regulate the immune status of the uterus. However, whether P and E 2 can affect the immune response of endometrial cell is still unknown. In the study, primary endometrial stromal cells (EndSCs) were treated with Poly(I:C), the pathogen-associated molecular pattern of double-stranded RNA (dsRNA) virus, to induce immune response, and then EndSCs were stimulated with P or/and E 2 . The results showed Poly(I:C) up-regulated the expression of immune cytokines IL-6, IL-8, IL-1β and TNF-α, and significantly down-regulated the expression of ERα and PGRMC1 in EndSCs. Moreover, P or low-dose of E 2 attenuate Poly(I:C)-induced immune response, and then the synergistic effects of P and E 2 decreased expression of ERα, ERβ and PGR, and alleviate the decease of PGRMC1 induced by Poly(I:C), but not alleviate the decease of ERα caused by Poly(I:C). The result provides a steroid therapeutic method to suppress dsRNA virtues-induced immune response through the synergistic effect of P and E 2 on endometrial stromal cells.
Competing Interests: Declaration of Competing Interest The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
(Copyright © 2024 Elsevier B.V. All rights reserved.)
- Contributed Indexing:
Keywords: Endometrial stromal cells; Estradiol; Immune cytokines; Poly(I:C); Progesterone
- Accession Number:
4TI98Z838E (Estradiol)
O84C90HH2L (Poly I-C)
4G7DS2Q64Y (Progesterone)
0 (Receptors, Progesterone)
0 (Cytokines)
0 (Estrogen Receptor alpha)
- Publication Date:
Date Created: 20240906 Date Completed: 20241207 Latest Revision: 20241207
- Publication Date:
20241209
- Accession Number:
10.1016/j.jri.2024.104318
- Accession Number:
39241576
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