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Tannic acid: A possible therapeutic agent for hypermethioninemia-induced neurochemical changes in young rats.
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- Additional Information
- Source:
Publisher: Elsevier Country of Publication: United States NLM ID: 0372516 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1090-2104 (Electronic) Linking ISSN: 0006291X NLM ISO Abbreviation: Biochem Biophys Res Commun Subsets: MEDLINE
- Publication Information:
Publication: <2002- >: San Diego, CA : Elsevier
Original Publication: New York, Academic Press.
- Subject Terms:
- Abstract:
This study explores the therapeutic benefits of tannic acid (TnA) in an experimental protocol of chronic hypermethioninemia in rats. Rats were categorized into four groups: Group I - control, Group II - TnA 30 mg/kg, Group III - methionine (Met) 0.2-0.4 g/kg + methionine sulfoxide (MS) 0.05-0.1 g/kg, Group IV - TnA/Met + MS. Saline was administered by subcutaneous pathway into groups I and II twice daily from postnatal day 6 (P6) to P28, whereas those in groups III and IV received Met + MS. From P28 to P35, groups II and IV received TnA orally. Animals from group III presented cognitive and memory impairment assessed through object recognition and Y-maze tests (p < 0.05). Elevated levels of reactive species, lipid peroxidation, and nitrites followed by a decline in sulfhydryl content, catalase activity, and superoxide dismutase activity were observed in animals treated with Met + MS (p < 0.05). However, TnA treatment reversed all these effects (p < 0.05). In group III, there was an increase in acetylcholinesterase activity and IL-6 levels, coupled with a reduction in Na + /K + -ATPase activity (p < 0.05). TnA was able to protect against these effects (p < 0.05). The gene expression of catalase, brain-derived neurotrophic factor, and nuclear factor erythroid 2-related factor 2 was decreased in the hippocampus and striatum from group III (p < 0.05). TnA reversed almost all of these alterations (p < 0.05). These findings suggest that TnA is a therapeutic target for patients with hypermethioninemia.
Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
(Copyright © 2024 Elsevier Inc. All rights reserved.)
- Contributed Indexing:
Keywords: Gene expression; Hypermethioninemia; Neuroprotection; Oxidative stress; Therapeutic
- Accession Number:
0 (Tannins)
0 (Brain-Derived Neurotrophic Factor)
EC 7.2.2.13 (Sodium-Potassium-Exchanging ATPase)
0 (tannic acid)
EC 2.1.1.20 (Glycine N-Methyltransferase)
0 (Polyphenols)
- Subject Terms:
Hypermethioninemia
- Publication Date:
Date Created: 20240905 Date Completed: 20241019 Latest Revision: 20241029
- Publication Date:
20241031
- Accession Number:
10.1016/j.bbrc.2024.150635
- Accession Number:
39236587
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