Nanocrystal hydroxyapatite carrying traditional Chinese medicine for osteogenic differentiation.

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  • Additional Information
    • Source:
      Publisher: Elsevier Country of Publication: Netherlands NLM ID: 9315133 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-4367 (Electronic) Linking ISSN: 09277765 NLM ISO Abbreviation: Colloids Surf B Biointerfaces Subsets: MEDLINE
    • Publication Information:
      Original Publication: Amsterdam ; New York : Elsevier, c1993-
    • Subject Terms:
    • Abstract:
      Developing biomaterials with high osteogenic properties is crucial for achieving rapid bone repair and regeneration. This study focuses on the application of nanocrystal hydroxyapatite (nHAp) as a drug carrier to load Fu Yuan Huo Xue Decoction (FYHXD), a traditional Chinese medicine derived from Angelica sinensis, aiming to achieve improved efficacy in treating bone diseases such as osteoporosis. Through a facile physical adsorption approach, the FTIR result emerges new characteristic absorption peaks in the range of 1200-950 cm -1 , proving the successful absorption of FYHXD onto the nHAp with a loading efficiency of 39.76 %. The modified nHAp exhibits a similar shape to the bone-derived hydroxyapatite nanocrystals, and their diameter increases slightly after modification. The drug release assay implies the rapid release of FYHXD in the first 10 h, followed by a continuously slow release within 70 h. The developed nHAp effectively enhances the adhesion, spreading, and proliferation of MC3T3-E1 cells in vitro, and significantly promotes their osteogenic differentiation, as indicated by increased alkaline phosphatase activity. Overall, the biocomposites hold great promise as active ingredients for integration into bone-associated biomaterials, offering the potential to stimulate spontaneous osteogenesis without requiring exogenous osteogenic factors.
      Competing Interests: Declaration of Competing Interest The authors declare no competing financial interest.
      (Copyright © 2024 Elsevier B.V. All rights reserved.)
    • Contributed Indexing:
      Keywords: Bioactive materials; Nanocrystal hydroxyapatite; Osteogenic differentiation; Physical adsorption; Traditional Chinese medicine
    • Accession Number:
      91D9GV0Z28 (Durapatite)
      0 (Drugs, Chinese Herbal)
      EC 3.1.3.1 (Alkaline Phosphatase)
      0 (Drug Carriers)
    • Publication Date:
      Date Created: 20240903 Date Completed: 20240915 Latest Revision: 20240915
    • Publication Date:
      20240916
    • Accession Number:
      10.1016/j.colsurfb.2024.114186
    • Accession Number:
      39226849