White matter correlates of cognition: A diffusion magnetic resonance imaging study.

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  • Additional Information
    • Source:
      Publisher: Elsevier/North-Holland Biomedical Press Country of Publication: Netherlands NLM ID: 8004872 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1872-7549 (Electronic) Linking ISSN: 01664328 NLM ISO Abbreviation: Behav Brain Res Subsets: MEDLINE
    • Publication Information:
      Original Publication: Amsterdam, Elsevier/North-Holland Biomedical Press.
    • Subject Terms:
      White Matter*/diagnostic imaging ; Executive Function*/physiology ; Cognition*/physiology ; Attention*/physiology ; Memory, Short-Term*/physiology; Humans ; Male ; Adult ; Female ; Young Adult ; Middle Aged ; Memory, Episodic ; Diffusion Magnetic Resonance Imaging ; Brain/diagnostic imaging ; Brain/physiology ; Cerebellum/diagnostic imaging ; Cerebellum/physiology ; Cerebellum/anatomy & histology ; Diffusion Tensor Imaging/methods ; Neuropsychological Tests
    • Abstract:
      Background: Our comprehension of the interplay of cognition and the brain remains constrained. While functional imaging studies have identified cognitive brain regions, structural correlates of cognitive functions remain underexplored. Advanced methods like Diffusion Magnetic Resonance Imaging (DMRI) facilitate the exploration of brain connectivity and White Matter (WM) tract microstructure. Therefore, we conducted connectometry method on DMRI data, to reveal WM tracts associated with cognition.
      Methods: 125 healthy participants from the National Institute of Mental Health Intramural Healthy Volunteer Dataset were recruited. Multiple regression analyses were conducted between DMRI-derived Quantitative Anisotropy (QA) values within WM tracts and scores of participants in Flanker Inhibitory Control and Attention Test (attention), Dimensional Change Card Sort (executive function), Picture Sequence Memory Test (episodic memory), and List Sorting Working Memory Test (working memory) tasks from National Institute of Health toolbox. The significance level was set at False Discovery Rate (FDR)<0.05.
      Results: We identified significant positive correlations between the QA of WM tracts within the left cerebellum and bilateral fornix with attention, executive functioning, and episodic memory (FDR=0.018, 0.0002, and 0.0002, respectively), and a negative correlation between QA of WM tracts within bilateral cerebellum with attention (FDR=0.028). Working memory demonstrated positive correlations with QA of left inferior longitudinal and left inferior fronto-occipital fasciculi (FDR=0.0009), while it showed a negative correlation with QA of right cerebellar tracts (FDR=0.0005).
      Conclusion: Our results underscore the intricate link between cognitive performance and WM integrity in frontal, temporal, and cerebellar regions, offering insights into early detection and targeted interventions for cognitive disorders.
      Competing Interests: Declaration of Competing Interest The authors of this paper declare no potential personal or financial conflicts of interest.
      (Copyright © 2024 Elsevier B.V. All rights reserved.)
    • Contributed Indexing:
      Keywords: Cognition; Diffusion MRI; Diffusion Tensor Imaging; White Matter
    • Publication Date:
      Date Created: 20240831 Date Completed: 20241027 Latest Revision: 20241027
    • Publication Date:
      20241028
    • Accession Number:
      10.1016/j.bbr.2024.115222
    • Accession Number:
      39216828