Integrating molecular-caged nano-hydroxyapatite into post-crosslinked PVA nanofibers for artificial periosteum.

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  • Additional Information
    • Source:
      Publisher: Elsevier B.V Country of Publication: Netherlands NLM ID: 9918383886206676 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2772-9508 (Electronic) Linking ISSN: 27729508 NLM ISO Abbreviation: Biomater Adv Subsets: MEDLINE
    • Publication Information:
      Original Publication: [Amsterdam] : Elsevier B.V., [2022]-
    • Subject Terms:
      Nanofibers*/chemistry ; Periosteum* ; Polyvinyl Alcohol*/chemistry ; Durapatite*/chemistry ; Durapatite*/pharmacology ; Osteogenesis*/drug effects; Humans ; Tissue Engineering/methods ; Tissue Scaffolds/chemistry ; Bone Regeneration/drug effects ; Cell Proliferation/drug effects ; Animals ; Biocompatible Materials/chemistry ; Cell Adhesion/drug effects ; Bone Substitutes/chemistry
    • Abstract:
      Artificial periosteum is deemed a novel strategy for inducing endogenous bone regeneration, but ideal periosteum substitutes achieved by orchestrating a biomimetic microenvironment for bone regeneration remain a significant challenge. Here, we design and fabricate a hybridized nanofiber-based artificial periosteum with boosted osteoinduction properties. Via a "molecular cage" biomineralization strategy, nano-hydroxyapatite (nano-HAp) with a controllable size (∼22 nm) and excellent dispersion serves as unique nano-additives for water-soluble polyvinyl-alcohol (PVA)-based artificial periosteum. The PVA/HAp composite is electrospun into nanofibers to replicate the extracellular-matrix-inspired nanostructure for inducing cell adhesion, proliferation, and fate manipulation. A simple post-crosslinking treatment is subsequently applied to further booster its mechanical strength (6.6 MPa) and swelling stability. The optimized sample of C-PVA/HAp (10 wt% nano-HAp) artificial periosteum features excellent biocompatibility and remarkable in vitro mineralization. Cell experiments demonstrate that its effectively boasted cell modulation for enhanced osteogenesis without the aid of growth factors, showing a possible activation of the ERK/MAPK signaling pathway. This work provides an effective strategy for designing novel HAp nano-additives and expands the possibility of biomimetic fabrication for more advanced nanofiber-based artificial periosteum.
      Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
      (Copyright © 2024 Elsevier B.V. All rights reserved.)
    • Contributed Indexing:
      Keywords: Artificial periosteum; Molecular cage; Nano-hydroxyapatite; Osteogenesis; PVA nanofibers
    • Accession Number:
      9002-89-5 (Polyvinyl Alcohol)
      91D9GV0Z28 (Durapatite)
      0 (Biocompatible Materials)
      0 (Bone Substitutes)
    • Publication Date:
      Date Created: 20240831 Date Completed: 20240914 Latest Revision: 20240914
    • Publication Date:
      20240916
    • Accession Number:
      10.1016/j.bioadv.2024.214001
    • Accession Number:
      39216317