Retinal Toxicity Assessment Following Vitreoretinal Surgery: A Comparison of Silicone Oil and Perfluoropropane Tamponade Using Diopsys ® NOVA ™ .

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  • Additional Information
    • Source:
      Publisher: Informa Healthcare Country of Publication: England NLM ID: 8104312 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1460-2202 (Electronic) Linking ISSN: 02713683 NLM ISO Abbreviation: Curr Eye Res Subsets: MEDLINE
    • Publication Information:
      Publication: London : Informa Healthcare
      Original Publication: London : IRL Press, [c1981-
    • Subject Terms:
      Silicone Oils* ; Fluorocarbons* ; Electroretinography* ; Endotamponade* ; Visual Acuity*/physiology ; Retinal Detachment*/surgery ; Vitreoretinal Surgery* ; Retina*/drug effects; Humans ; Male ; Female ; Prospective Studies ; Middle Aged ; Aged ; Adult ; Vitrectomy ; Follow-Up Studies
    • Abstract:
      Purpose: This study aimed to assess and compare the retinal toxicity associated with silicone oil (SO) and perfluoropropane (C3F8) tamponade following vitreoretinal surgery for fresh rhegmatogenous retinal detachment (RRD), utilizing the office-based Diopsys ® NOVA ™ system for evaluation.
      Methods: Patients who underwent vitreoretinal surgery for fresh RRD and had SO (group 1) or C3F8 (group 2) tamponade were included in a prospective analysis. Flicker full field electroretinography (ffERG) and pattern electroretinography (PERG) tests were performed at 6 months postoperatively.
      Results: Postoperative best corrected visual acuity (logMAR) was significantly different in group 1 and group 2 patients, 0.48 ± 0.3 and 0.30 ± 0.2, respectively. No significant disparities were found in demographic variables. Flicker ffERG and PERG recordings revealed notable alterations in retinal function parameters in the group 1 compared to the group 2.
      Conclusion: Our findings suggest a correlation between SO tamponade and retinal dysfunction, evidenced by office-based ERG measurements. The Diopsys ® NOVA ™ protocol offers clinical ease in assessing retinal function. Further controlled studies are essential to validate these findings and guide clinical practice effectively.
    • Contributed Indexing:
      Keywords: Diopsys® NOVA™; full field electroretinography; pattern electroretinography; perfluoropropane; silicone oil
    • Accession Number:
      0 (Silicone Oils)
      0 (Fluorocarbons)
      CK0N3WH0SR (perflutren)
    • Publication Date:
      Date Created: 20240830 Date Completed: 20241223 Latest Revision: 20241223
    • Publication Date:
      20241223
    • Accession Number:
      10.1080/02713683.2024.2394118
    • Accession Number:
      39212476