Association of computed tomography-derived pectoralis muscle area and density with disease severity and respiratory symptoms in patients with chronic obstructive pulmonary disease: A case-control study.

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  • Additional Information
    • Source:
      Publisher: Elsevier Country of Publication: England NLM ID: 8908438 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1532-3064 (Electronic) Linking ISSN: 09546111 NLM ISO Abbreviation: Respir Med Subsets: MEDLINE
    • Publication Information:
      Publication: 2003- : Oxford : Elsevier
      Original Publication: London : Baillière Tindall, in association with the British Thoracic Society, [c1989-
    • Subject Terms:
      Pulmonary Disease, Chronic Obstructive*/diagnostic imaging ; Pulmonary Disease, Chronic Obstructive*/physiopathology ; Pulmonary Disease, Chronic Obstructive*/pathology ; Pectoralis Muscles*/diagnostic imaging ; Pectoralis Muscles*/pathology ; Pectoralis Muscles*/physiopathology ; Tomography, X-Ray Computed*/methods ; Severity of Illness Index*; Humans ; Case-Control Studies ; Male ; Female ; Aged ; Middle Aged ; Respiratory Function Tests
    • Abstract:
      Rationale and Objectives: Computed tomography (CT) is commonly used and offers an additional viewpoint for evaluating extrapulmonary symptoms, disease severity, and muscle atrophy. This study assessed whether the pectoralis muscle area (PMA) and pectoralis muscle density (PMD) are lower in patients with chronic obstructive pulmonary disease (COPD) than in healthy controls and elucidated their relationships with these variables.
      Materials and Methods: The participants were enrolled in the hospital outpatient clinic between October 2023 and May 2024. Information was obtained from questionnaires, lung function, and CT imaging findings. On full-inspiratory CT, the PMA and PMD were measured at the aortic arch level using predetermined attenuation ranges of -29 and 150 Hounsfield units. We observed lower PMA and PMD and evaluated their associations with lung function, respiratory symptoms, and CT imaging findings in patients with COPD.
      Results: Overall, 120 participants were enrolled at baseline (60 healthy controls and 60 patients with COPD). PMA and PMD were lower with progressive airflow limitation severity in those with COPD. The degree of emphysema and air trapping, as well as lung function, were correlated with PMA and PMD (P < 0.05), although not with the COPD Assessment Test or modified Medical Research Council scores (P > 0.05).
      Conclusion: Participants with COPD had smaller PMA and PMD. These measurements were correlated with the severity of airflow limitation, lung function, emphysema, and air trapping, suggesting that these features of the pectoralis muscle obtained from CT are helpful in assessments of patients with COPD.
      Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
      (Copyright © 2024 Elsevier Ltd. All rights reserved.)
    • Grant Information:
      12174203 National Natural Science Foundation of China; (21JCYBJC00120) Scientific and Technological Projects of Tianjin; 2022KJ268 Tianjin Education Commission Scientific Research Project
    • Contributed Indexing:
      Keywords: Chronic obstructive pulmonary disease; Computed tomography; Pectoralis muscle area; Pectoralis muscle density
    • Publication Date:
      Date Created: 20240829 Date Completed: 20240908 Latest Revision: 20241010
    • Publication Date:
      20241010
    • Accession Number:
      10.1016/j.rmed.2024.107783
    • Accession Number:
      39209127