Expert consensus on the multidisciplinary diagnosis and treatment of multiple ground glass nodule-like lung cancer (2024 Edition).

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      Publisher: Medknow Publications Country of Publication: India NLM ID: 101249598 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1998-4138 (Electronic) Linking ISSN: 19984138 NLM ISO Abbreviation: J Cancer Res Ther Subsets: MEDLINE
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      Original Publication: Mumbai, India : Medknow Publications
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    • Abstract:
      Abstract: This expert consensus reviews current literature and provides clinical practice guidelines for the diagnosis and treatment of multiple ground glass nodule-like lung cancer. The main contents of this review include the following: ① follow-up strategies, ② differential diagnosis, ③ diagnosis and staging, ④ treatment methods, and ⑤ post-treatment follow-up.
      (Copyright © 2024 Copyright: © 2024 Journal of Cancer Research and Therapeutics.)
    • References:
      Data visualization tools for exploring the global cancer burden in 2022. 2024. Available from: https://gco.iarc.who.int/today/home .
      Leiter A, Veluswamy RR, Wisnivesky JP The global burden of lung cancer: Current status and future trends. Nat Rev Clin Oncol 2023; 20: 624–39.
      Han B, Zheng R, Zeng H, Wang S, Sun K, Chen R, et al. Cancer incidence and mortality in China, 2022. J Natl Cancer Cent 2024; 4: 47–53.
      National Lung Screening Trial Research Team Aberle DR, Adams AM, Berg CD, Black WC, Clapp JD, et al. Reduced lung-cancer mortality with low-dose computed tomographic screening. N Engl J Med 2011; 365: 395–409.
      He YT, Zhang YC, Shi GF, Wang Q, Xu Q, Liang D, et al. Risk factors for pulmonary nodules in north China: A prospective cohort study. Lung Cancer 2018; 120: 122–9.
      Yang W, Qian F, Teng J, Wang H, Manegold C, Pilz LR, et al. Community-based lung cancer screening with low-dose CT in China: Results of the baseline screening. Lung Cancer 2018; 117: 20–6.
      Fan L, Wang Y, Zhou Y, Li Q, Yang W, Wang S, et al. Lung cancer screening with low-dose CT: Baseline screening results in Shanghai. Acad Radiol 2019; 26: 1283–91.
      Xu GH, Huang HX, Chen B, Luo DY, Wu JB, Zuo X, et al. A study on the first chest low-dose CT screening and susceptible factors of pulmonary nodules in 23,695 physical examinees in a medical examination center. Fudan Xue Bao (Yi Xue Ban) [Chinese] 2020; 47: 654–9.
      Liang X, Kong Y, Shang H, Yang M, Lu W, Zeng Q, et al. Computed tomography findings, associated factors, and management of pulmonary nodules in 54,326 healthy individuals. J Cancer Res Ther 2022; 18: 2041–8.
      Yankelevitz DF, Yip R, Smith JP, Liang M, Liu Y, Xu DM, et al. CT Screening for lung cancer: Nonsolid nodules in baseline and annual repeat rounds. Radiology 2015; 277: 555–564.
      Van Haren RM, Correa AM, Sepesi B, Rice DC, Hofstetter WL, Mehran RJ, et al. Ground glass lesions on chest imaging: Evaluation of reported incidence in cancer patients using natural language processing. Ann Thorac Surg 2019; 107: 936–40.
      Hu J, Wang XD Pulmonary focal ground glass nodules detected by chest CT in healthy adults in Jinan. Zhongguo Linchuang Yanjiu 2021; 34: 1190–3. 1198 [Chinese].
      Baldwin DR, Callister ME Guideline Development Group The British Thoracic Society guidelines on the investigation and management of pulmonary nodules. Thorax 2015; 70: 794–8.
      MacMahon H, Naidich DP, Goo JM, Lee KS, Leung ANC, Mayo JR, et al. Guidelines for management of incidental pulmonary nodules detected on CT images: From the Fleischner Society 2017. Radiology 2017; 284: 228–43.
      Zhou Q, Fan Y, Wang Y, Qiao Y, Wang G, Huang Y, et al. China National Guideline of Classification, Diagnosis and Treatment for Lung Nodules (2016 Version). Zhongguo Fei Ai Za Zhi 2016; 19: 793–8. [Chinese].
      Lee HY, Choi YL, Lee KS, Han J, Zo JI, Shim YM, et al. Pure ground-glass opacity neoplastic lung nodules: Histopathology, imaging, and management. AJR Am J Roentgenol 2014; 202: W224–33.
      Ye X, Fan W, Wang Z, Wang J, Wang H, Wang J, et al. Expert consensus for thermal ablation of pulmonary subsolid nodules (2021 Edition). Zhongguo Fei Ai Za Zhi 2021; 24: 305–22. [Chinese].
      Yatabe Y, Borczuk AC, Powell CA Do all lung adenocarcinomas follow a stepwise progression. Lung Cancer 2011; 74: 7–11.
      He Y, Liu X, Wang H, Wu L, Jiang M, Guo H, et al. Mechanisms of progression and heterogeneity in multiple nodules of lung adenocarcinoma. Small Methods 2021; 5: e2100082.
      Detterbeck FC, Bolejack V, Arenberg DA, Crowley J, Donington JS, Franklin WA, et al. The IASLC lung cancer staging project: Background data and proposals for the classification of lung cancer with separate tumor nodules in the forthcoming eighth edition of the TNM classification for lung cancer. J Thorac Oncol 2016; 11: 681–92.
      Gao JW, Rizzo S, Ma LH, Qiu XY, Warth A, Seki N, et al. Pulmonary ground-glass opacity: Computed tomography features, histopathology and molecular pathology. Transl Lung Cancer Res 2017; 6: 68–75.
      Book-And-Report-Series/Who-Classification-Of-Tumours/Thoracic-Tumours-2021. Available from: https://publications.iarc.fr/ .
      Heuvelmans MA, Walter JE, Peters RB, Bock GH, Yousaf-Khan U, Aalst CMV, et al. Relationship between nodule count and lung cancer probability in baseline CT lung cancer screening: The NELSON study. Lung Cancer 2017; 113: 45–50.
      Liu B, Ye X Management of pulmonary multifocal ground-glass nodules: How many options do we have?. J Cancer Res Ther 2020; 16: 199–202.
      Hotta T, Tsubata Y, Tanino A, Nakao M, Amano Y, Hamaguchi M, et al. Comparative postoperative outcomes of GGN-dominant vs single lesion lung adenocarcinomas. J Cardiothorac Surg 2020; 15: 149.
      Kim TJ, Goo JM, Lee KW, Park CM, Lee HJ Clinical, pathological and thin-section CT features of persistent multiple ground-glass opacity nodules: Comparison with solitary ground-glass opacity nodule. Lung Cancer 2009; 64: 171–8.
      Kim BG, Um SW A narrative review of the clinical approach to subsolid pulmonary nodules. Ann Transl Med 2023; 11: 217.
      Hattori A, Matsunaga T, Takamochi K, Oh S, Suzuki K Radiological classification of multiple lung cancers and the prognostic impact based on the presence of a ground glass opacity component on thin-section computed tomography. Lung Cancer 2017; 113: 7–13.
      Hattori A, Matsunaga T, Takamochi K, Oh S, Suzuki K Surgical management of multifocal ground-glass opacities of the lung: Correlation of clinicopathologic and radiologic findings. Thorac Cardiovasc Surg 2017; 65: 142–9.
      Hattori A, Takamochi K, Oh S, Suzuki K Prognostic classification of multiple primary lung cancers based on a ground-glass opacity component. Ann Thorac Surg 2020; 109: 420–7.
      Taralli S, Scolozzi V, Foti M, Ricciardi S, Forcione AR, Cardillo G, et al. 18F-FDG PET/CT diagnostic performance in solitary and multiple pulmonary nodules detected in patients with previous cancer history: Reports of 182 nodules. Eur J Nucl Med Mol Imaging 2019; 46: 429–36.
      Gu B, Burt BM, Merritt RE, Stephanie S, Nair V, Hoang CD, et al. A dominant adenocarcinoma with multifocal ground glass lesions does not behave as advanced disease. Ann Thorac Surg 2013; 96: 411–8.
      Liu B Diagnosis and treatment of pulmonary multifocal ground-glass nodules. Zhongguo Fei Ai Za Zhi 2020; 23: 679–84.
      Bueno J, Landeras L, Chung JH Updated Fleischner Society Guidelines for managing incidental pulmonary nodules: Common questions and challenging scenarios. Radiographics 2018; 38: 1337–50.
      Li M, Wu N, Zhang L, Sun W, Liu Y, Lv L, et al. Solid component proportion is an important predictor of tumor invasiveness in clinical stage T1N0M0 (cT1N0M0) lung adenocarcinoma. Cancer Imaging 2018; 18: 18.
      Shimada Y, Saji H, Otani K, Maehara S, Maeda J, Yoshida K, et al. Survival of a surgical series of lung cancer patients with synchronous multiple ground-glass opacities, and the management of their residual lesions. Lung Cancer 2015; 88: 174–80.
      Chen K, Chen W, Cai J, Yang F, Lou F, Wang X, et al. Favorable prognosis and high discrepancy of genetic features in surgical patients with multiple primary lung cancers. J Thorac Cardiovasc Surg 2018; 155: 371–9.
      Gould MK, Donington J, Lynch WR, Mazzone PJ, Midthun DE, Naidich DP, et al. Evaluation of individuals with pulmonary nodules: When is it lung cancer? Diagnosis and management of lung cancer, 3 rd ed: American College of Chest Physicians evidence-based clinical practice guidelines. Chest 2013; 143: e93S–120S.
      Lung Cancer Study Group, Chinese Thoracic Society, Chinese Medical Association;Chinese Alliance Against Lung Cancer Chinese Expert Consensus on diagnosis and treatment of pulmonary nodules (2018 version). Zhonghua Jie He He Hu Xi Za Zhi 2018; 41: 763–71. [Chinese].
      He J, Li N, Chen WQ, Wu N, Shen HB, Jiang Y, et al. China guideline for the screening and early detection of lung cancer (2021, Beijing). Zhonghua Zhong Liu Za Zhi 2021; 43: 243–68. [Chinese].
      NCCN Clinical Practice Guidelines in Oncology: Lung Cancer Screening (Version 1.2023). NCCN Guidelines for Patients. Available from: www.nccn.org/patients .
      Leventakos K, Peikert T, Midthun DE, Molina JR, Blackmon S, Nichols FC, et al. Management of multifocal lung cancer: Results of a survey. J Thoracic Oncol 2017; 12: 1398–402.
      Cho J, Kim ES, Kim SJ, Lee YJ, Park JS, Cho YJ, et al. Long-term follow-up of small pulmonary ground-glass nodules stable for 3 years: Implications of the proper follow-up period and risk factors for subsequent growth. J Thorac Oncol 2016; 11: 1453–9.
      Sato Y, Fujimoto D, Morimoto T, Uehara K, Nagata K, Sakanoue I, et al. Natural history and clinical characteristics of multiple pulmonary nodules with ground glass opacity. Respirology 2017; 22: 1615–21.
      Loverdos K, Fotiadis A, Kontogianni C, Iliopoulou M, Gaga M Lung nodules: A comprehensive review on current approach and management. Ann Thorac Med 2019; 14: 226–38.
      Horeweg N, van der Aalst CM, Vliegenthart R, Zhao Y, Xie X, Scholten ET, et al. Volumetric computed tomography screening for lung cancer: Three rounds of the NELSON trial. Eur Respir J 2013; 42: 1659–67.
      Libby DM, Wu N, Lee IJ, Farooqi A, Smith JP, Pasmantier MW, et al. CT screening for lung cancer: The value of short-term CT follow-up. Chest 2006; 129: 1039–42.
      Liu BD, Chen HQ, Liu LX, Jiang GN, Zhi XY Chinese expert consensus on multidisciplinary minimally invasive diagnosis and treatment of pulmonary nodules. Zhongguo Xiongxin Xueguan Waike Linchuang Zazhi 2023; 30: 1061–74. [Chinese].
      Lee HW, Jin KN, Lee JK, Kim DK, Chung HS, Heo EY, et al. Long-term follow-up of ground-glass nodules after 5 years of stability. J Thorac Oncol 2019; 14: 1370–7.
      Nasim F, Ost DE Management of the solitary pulmonary nodule. Curr Opin Pulm Med 2019; 25: 344–53.
      Hanaoka T, Kurai M, Okada M, Ishizone S, Karasawa F, Iizuka A Preoperative watchful-waiting time and surgical outcome of patients with non-small cell lung cancer found by chest low-dose CT screening. World J Surg 2018; 42: 2164–72.
      Seok Y, Cho S, Kim K, Jheon S Partly solid pulmonary nodules: Waiting for change or surgery outright?. Interact Cardiovasc Thorac Surg 2014; 19: 556–60.
      Gulati CM, Schreiner AM, Libby DM, Port JL, Altorki NK, Gelbman BD Outcomes of unresected ground-glass nodules with cytology suspicious for adenocarcinoma. J Thorac Oncol 2014; 9: 685–91.
      Detterbeck FC, Nicholson AG, Franklin WA, Marom EM, Travis WD, Girard N, et al. The IASLC lung cancer staging project: Summary of proposals for revisions of the classification of lung cancers with multiple pulmonary sites of involvement in the forthcoming eighth edition of the TNM classification. J Thorac Oncol 2016; 11: 639–50.
      Detterbeck FC, Marom EM, Arenberg DA, Franklin WA, Nicholson AG, Travis WD, et al. The IASLC lung cancer staging project: Background data and proposals for the application of TNM staging rules to lung cancer presenting as multiple nodules with ground glass or lepidic features or a pneumonic type of involvement in the forthcoming eighth edition of the TNM classification. J Thorac Oncol 2016; 11: 666–80.
      Martini N, Melamed MR Multiple primary lung cancers. J Thorac Cardiovasc Surg 1975; 70: 606–12.
      Kozower BD, Larner JM, Detterbeck FC, Jones DR Special treatment issues in non-small cell lung cancer: Diagnosis and management of lung cancer, 3 rd ed: American College of Chest Physicians evidence-based clinical practice guidelines. Chest 2013; 143: e369S–99S.
      Girard N, Deshpande C, Lau C, Finley D, Rusch V, Pao W, et al. Comprehensive histologic assessment helps to differentiate multiple lung primary nonsmall cell carcinomas from metastases. Am J Surg Pathol 2009; 33: 1752–64.
      Antakli T, Schaefer RF, Rutherford JE, Read RC Second primary lung cancer. Ann Thorac Surg 1995; 59: 863–6. discussion 867.
      Wu C, Zhao C, Yang Y, He Y, Hou L, Li X, et al. High discrepancy of driver mutations in patients with NSCLC and synchronous multiple lung ground-glass nodules. J Thorac Oncol 2015; 10: 778–83.
      Liu M, He WX, Song N, Yang Y, Zhang P, Jiang GN Discrepancy of epidermal growth factor receptor mutation in lung adenocarcinoma presenting as multiple ground-glass opacities. Eur J Cardiothorac Surg 2016; 50: 909–13.
      Park E, Ahn S, Kim H, Park SY, Lim J, Kwon HJ, et al. Targeted sequencing analysis of pulmonary adenocarcinoma with multiple synchronous ground-glass/lepidic nodules. J Thorac Oncol 2018; 13: 1776–83.
      Lee CT Multifocal ground-glass opacities: Multifocal origin versus intrapulmonary metastasis. J Thorac Dis 2018; 10: 1253–5.
      Ma P, Fu Y, Cai MC, Yan Y, Jing Y, Zhang S, et al. Simultaneous evolutionary expansion and constraint of genomic heterogeneity in multifocal lung cancer. Nat Commun 2017; 8: 823.
      Mansuet-Lupo A, Barritault M, Alifano M, Janet-Vendroux A, Zarmaev M, Biton J, et al. Proposal for a combined histomolecular algorithm to distinguish multiple primary adenocarcinomas from intrapulmonary metastasis in patients with multiple lung tumors. J Thorac Oncol 2019; 14: 844–56.
      Suh YJ, Lee HJ, Sung P, Yoen H, Kim S, Han S, et al. A novel algorithm to differentiate between multiple primary lung cancers and intrapulmonary metastasis in multiple lung cancers with multiple pulmonary sites of involvement. J Thorac Oncol 2020; 15: 203–15.
      Wang Z, Yuan X, Jiang G, Li Y, Yang F, Wang J, et al. Towards the molecular era of discriminating multiple lung cancers. EBioMedicine 2023; 90: 104508.
      Yu F, Huang X, Zhou D, Zhao Z, Wu F, Qian B, et al. Genetic, DNA methylation, and immune profile discrepancies between early-stage single primary lung cancer and synchronous multiple primary lung cancer. Clin Epigenetics 2023; 15: 4.
      Song Y, Liang NX, Li SQ The clinical and molecular characteristics of adenocarcinoma presented by multi-focal GGO. Zhongguo Fei Ai Za Zhi 2018; 21: 163–7. [Chinese].
      Hattori A, Suzuki K, Takamochi K, Oh S Clinical features of multiple lung cancers based on thin-section computed tomography: What are the appropriate surgical strategies for second lung cancers?. Surg Today 2015; 45: 189–96.
      Lim J, Han YB, Park SY, Ahn S, Kim H, Kwon HJ, et al. Gene expression profiles of multiple synchronous lesions in lung adenocarcinoma. Cells 2021; 10: 3484.
      Kou J, Gu X, Yu Y, Zheng S CT imaging features regarding ground-glass nodules and solid lesions reflect prognostication of synchronous multiple lung adenocarcinoma. Medicine (Baltimore) 2022; 101: e31339.
      McWilliams A, Tammemagi MC, Mayo JR, Roberts H, Liu G, Soghrati K, et al. Probability of cancer in pulmonary nodules detected on first screening CT. N Engl J Med 2013; 369: 910–9.
      Niyonkuru A, Bakari KH, Lan X 18F-Fluoro-2-deoxy-d-glucose PET/computed tomography evaluation of lung cancer in populations with high prevalence of tuberculosis and other granulomatous disease. PET Clin 2018; 13: 19–31.
      Ruilong Z, Daohai X, Li G, Xiaohong W, Chunjie W, Lei T Diagnostic value of 18F-FDG-PET/CT for the evaluation of solitary pulmonary nodules: A systematic review and meta-analysis. Nucl Med Commun 2017; 38: 67–75.
      Li W, Pang H, Liu Q, Zhou J The role of 18 F-FDG PET or 18 F-FDG-PET/CT in the evaluation of solitary pulmonary nodules. Eur J Radiol 2015; 84: 2032–7.
      Hochhegger B, Alves GR, Irion KL, Fritscher CC, Fritscher LG, Concatto NH, et al. PET/CT imaging in lung cancer: Indications and findings. J Bras Pneumol 2015; 41: 264–74.
      Niu R, Shao X, Shao X, Wang J, Jiang Z, Wang Y Lung adenocarcinoma manifesting as ground-glass opacity nodules 3 cm or smaller: Evaluation with combined high-resolution CT and PET/CT modality. AJR Am J Roentgenol 2019; 213: W236–45.
      Niu R, Wang Y, Shao X, Jiang Z, Wang J, Shao X Association between 18F-FDG PET/CT-based SUV index and malignant status of persistent ground-glass nodules. Front Oncol 2021; 11: 594693.
      McDermott S, Kilcoyne A, Wang Y, Scott JA, Halpern EF, Ackman JB Comparison of the 18F-FDG avidity at PET of benign and malignant pure ground-glass opacities: A paradox?. Clin Radiol 2019; 74: 187–95.
      Ather S, Kadir T, Gleeson F Artificial intelligence and radiomics in pulmonary nodule management: Current status and future applications. Clin Radiol 2020; 75: 13–9.
      Fogel AL, Kvedar JC Benefits and risks of machine learning decision support systems. JAMA 2017; 318: 2356.
      Sim Y, Chung MJ, Kotter E, Yune S, Kim M, Do S, et al. Deep convolutional neural network-based software improves radiologist detection of malignant lung nodules on chest radiographs. Radiology 2020; 294: 199–209.
      Greffier J, Si-Mohamed S, Frandon J, Loisy M, de Oliveira F, Beregi JP, et al. Impact of an artificial intelligence deep-learning reconstruction algorithm for CT on image quality and potential dose reduction: A phantom study. Med Phys 2022; 49: 5052–63.
      Wang X, Gao M, Xie J, Deng Y, Tu W, Yang H, et al. Development, validation, and comparison of image-based, clinical feature-based and fusion artificial intelligence diagnostic models in differentiating benign and malignant pulmonary ground-glass nodules. Front Oncol 2022; 12: 892890.
      Gong J, Liu J, Hao W, Nie S, Zheng B, Wang S, et al. A deep residual learning network for predicting lung adenocarcinoma manifesting as ground-glass nodule on CT images. Eur Radiol 2020; 30: 1847–55.
      Chao HS, Tsai CY, Chou CW, Shiao TH, Huang HC, Chen KC, et al. Artificial intelligence assisted computational tomographic detection of lung nodules for prognostic cancer examination: A large-scale clinical trial. Biomedicines 2023; 11: 147.
      Singh R, Kalra MK, Homayounieh F, Nitiwarangkul C, McDermott S, Little BP, et al. Artificial intelligence-based vessel suppression for detection of sub-solid nodules in lung cancer screening computed tomography. Quant Imaging Med Surg 2021; 11: 1134–43.
      Ye X, Fan W, Wang Z, Wang J, Wang H, Wang J, et al. Expert consensus on thermal ablation therapy of pulmonary subsolid nodules (2021 Edition). J Cancer Res Ther 2021; 17: 1141–56.
      Yoon SH, Lee SM, Park CH, Lee JH, Kim H, Chae KJ, et al. 2020 Clinical practice guideline for percutaneous transthoracic needle biopsy of pulmonary lesions: A consensus statement and recommendations of the Korean Society of Thoracic Radiology. Korean J Radiol 2021; 22: 263–80.
      Yoon SH, Park CM, Lee KH, Lim KY, Suh YJ, Im DJ, et al. Analysis of complications of percutaneous transthoracic needle biopsy using CT-guidance modalities in a multicenter cohort of 10568 biopsies. Korean J Radiol 2019; 20: 323–31.
      Interventional Oncology Committee, Chinese Anti-cancer Association, Thoracic Expert Committee of Interventional Oncology, Chinese Anti-Cancer Association. Clinical practice guideline for percutaneous transthoracic needle biopsy: A consensus statement and recommendations (2020 update). Zhonghua Yi Xue Za Zhi 2021; 09: 117–26. [Chinese].
      Li Z, Zhao F, Wang G, Xue G, Wang N, Cao P, et al. Changes in the pulmonary function of CT-guided microwave ablation for patients with malignant lung tumors. J Cancer Res Ther 2023; 19: 1669–4.
      Wang B, Zhong F, An W, Liao M The diagnostic value of CT-guided percutaneous puncture biopsy of pulmonary ground-glass nodules: A meta-analysis. Acta Radiol 2023; 64: 1431–14.
      Tsai PC, Yeh YC, Hsu PK, Chen CK, Chou TY, Wu YC CT-guided core biopsy for peripheral sub-solid pulmonary nodules to predict predominant histological and aggressive subtypes of lung adenocarcinoma. Ann Surg Oncol 2020; 27: 4405–12.
      Halpenny D, Das K, Ziv E, Plodkowski A, Zheng J, Capanu M, et al. Percutaneous computed tomography guided biopsy of sub-solid pulmonary nodules: Differentiating solid from ground glass components at the time of biopsy. Clin Imaging 2021; 69: 332–8.
      Zhu S, Li J, Guan W, Li H, Fan W, Wu D, et al. Clinical application of radiofrequency ablation-assisted coaxial trocar biopsies for pulmonary nodules at a high risk of bleeding. J Cancer Res Ther 2023; 19: 972–7.
      Chi J, Ding M, Wang Z, Hu H, Shi Y, Cui D, et al. Pathologic diagnosis and genetic analysis of sequential biopsy following coaxial low-power microwave thermal coagulation for pulmonary ground-glass opacity nodules. Cardiovasc Intervent Radiol 2021; 44: 1204–13.
      Wang J, Ni Y, Yang X, Huang G, Wei Z, Li W, et al. Diagnostic ability of percutaneous core biopsy immediately after microwave ablation for lung ground-glass opacity. J Cancer Res Ther 2019; 15: 755–9.
      Hasegawa T, Kondo C, Sato Y, Inaba Y, Yamaura H, Kato M, et al. Pathologic diagnosis and genetic analysis of a lung tumor needle biopsy specimen obtained immediately after radiofrequency ablation. Cardiovasc Intervent Radiol 2018; 41: 594–602.
      Hasegawa T, Kondo C, Sato Y, Inaba Y, Yamaura H, Kato M, et al. Diagnostic ability of percutaneous needle biopsy immediately after radiofrequency ablation for malignant lung tumors: An initial experience. Cardiovasc Intervent Radiol 2016; 39: 1187–92.
      Mohapatra MM, Rajaram M, Gochhait D, Kumar SV, Chakkalakkoombil SV Can combined non-invasive methods improve diagnosis of lung cancer?. J Cancer Res Ther 2023; 19: 1142–7.
      Kong F, Wang C, Li Y, Li X Advances in study of the sequence of lung tumor biopsy and thermal ablation. Thorac Cancer 2021; 12: 279–86.
      Wang N, Xu J, Xue G, Han C, Zhang H, Zhao W, et al. Synchronous computed tomography-guided percutaneous biopsy and microwave ablation for highly suspicious malignant lung ground-glass opacities adjacent to mediastinum. Int J Hyperthermia 2023; 40: 2193362.
      Xu JM, Yu YC, Liu Z, Liu Y, Wang FT Application of 3D-printed coplanar template combined with fixed needle technique in percutaneous accurate biopsy of small pulmonary nodules. Zhongguo Zuzhi Gongcheng Yanjiu 2021; 25: 761–4. [Chinese].
      Ji Z, Wang G, Chen B, Zhang Y, Zhang L, Gao F, et al. Clinical application of planar puncture template-assisted computed tomography-guided percutaneous biopsy for small pulmonary nodules. J Cancer Res Ther 2018; 14: 1632–7.
      Wang H, Ren T, Chen P, Luo G, Wei N, Tang Y, et al. Application of 3-dimensionally printed coplanar template improves diagnostic yield of ct-guided percutaneous core needle biopsy for pulmonary nodules. Technol Cancer Res Treat 2022; 21: 15330338221089940.
      Meng M, Huang G, Wang J, Li W, Ni Y, Zhang T, et al. Facilitating combined biopsy and percutaneous microwave ablation of pulmonary ground-glass opacities using lipiodol localisation. Eur Radiol 2023; 33: 3124–32.
      Nadig TR, Thomas N, Nietert PJ, Lozier J, Tanner NT, Wang Memoli JS, et al. Guided bronchoscopy for the evaluation of pulmonary lesions: An updated meta-analysis. Chest 2023; 163: 1589–98.
      Han Y, Kim HJ, Kong KA, Kim SJ, Lee SH, Ryu YJ, et al. Diagnosis of small pulmonary lesions by transbronchial lung biopsy with radial endobronchial ultrasound and virtual bronchoscopic navigation versus CT-guided transthoracic needle biopsy: A systematic review and meta-analysis. PLoS One 2018; 13: e0191590.
      Jiang S, Liu X, Chen J, Ma H, Xie F, Sun J A pilot study of the ultrathin cryoprobe in the diagnosis of peripheral pulmonary ground-glass opacity lesions. Transl Lung Cancer Res 2020; 9: 1963–73.
      Folch EE, Bowling MR, Pritchett MA, Murgu SD, Nead MA, Flandes J, et al. NAVIGATE 24-month results: Electromagnetic navigation bronchoscopy for pulmonary lesions at 37 centers in Europe and the United States. J Thorac Oncol 2022; 17: 519–31.
      Sainz Zuñiga PV, Vakil E, Molina S, Bassett RL Jr, Ost DE Sensitivity of radial endobronchial ultrasound-guided bronchoscopy for lung cancer in patients with peripheral pulmonary lesions: An updated meta-analysis. Chest 2020; 157: 994–1011.
      Chen AC, Pastis NJ Jr, Mahajan AK, Khandhar SJ, Simoff MJ, Machuza, et al. Robotic bronchoscopy for peripheral pulmonary lesions: A multicenter pilot and feasibility study (BENEFIT). Chest 2021; 159: 845–52.
      Simoff MJ, Pritchett MA, Reisenauer JS, Ost DE, Majid A, Keyes C, et al. Shape-sensing robotic-assisted bronchoscopy for pulmonary nodules: Initial multicenter experience using the Ion™Endoluminal System. BMC Pulm Med 2021; 21: 322.
      Rocco G, Romano V, Accardo R, Tempesta A, La Manna C, La Rocca A, et al. Awake single-access (uniportal) video-assisted thoracoscopic surgery for peripheral pulmonary nodules in a complete ambulatory setting. Ann Thorac Surg 2010; 89: 1625–7.
      Lee K, Kim HR, Park SI, Kim DK, Kim YH, Choi S, et al. Natural progression of ground-glass nodules after curative resection for non-small cell lung cancer. J Korean Med Sci 2021; 36: e266.
      Zhang Y, Li G, Li Y, Liu Q, Yu Y, Ma Y, et al. Imaging features suggestive of multiple primary lung adenocarcinomas. Ann Surg Oncol 2020; 27: 2061–70.
      Zhang Y, Fu F, Chen H Management of ground-glass opacities in the lung cancer spectrum. Ann Thorac Surg 2020; 110: 1796–804.
      Cho H, Lee HY, Kim J, Kim HK, Choi JY, Um SW, et al. Pure ground glass nodular adenocarcinomas: Are preoperative positron emission tomography/computed tomography and brain magnetic resonance imaging useful or necessary?. J Thorac Cardiovasc Surg 2015; 150: 514–20.
      Li H, Ye T, Li N, Xia G, Li B, Zhang Y, et al. Is 99m Tc bone scintigraphy necessary in the preoperative workup for patients with cT1N0 subsolid lung cancer? A prospective multicenter cohort study. Thorac Cancer 2021; 12: 415–9.
      Yang X, Jin Y, Lin Z, Li X, Huang G, Ni Y, et al. Microwave ablation for the treatment of peripheral ground-glass nodule-like lung cancer: Long-term results from a multi-center study. J Cancer Res Ther 2023; 19: 1001–10.
      Wei Z, Iezzi R, Ye X Editorial: Local ablative therapies for the management of lung cancer. Front Oncol 2023; 13: 1160932.
      Tsutsui S, Ashizawa K, Minami K, Tagawa T, Nagayasu T, Hayashi T, et al. Multiple focal pure ground-glass opacities on high-resolution CT images: Clinical significance in patients with lung cancer. AJR Am J Roentgenol 2010; 195: W131–8.
      Nakata M, Sawada S, Yamashita M, Saeki H, Kurita A, Takashima S, et al. Surgical treatments for multiple primary adenocarcinoma of the lung. Ann Thorac Surg 2004; 78: 1194–9.
      Zhang Y, Wang Y, Lv C, Shu X, Wang J, Yang Q Clinical analysis of 56 cases of simultaneous bilateral video-assisted thoracoscopic surgery for bilateral synchronous multiple primary lung adenocarcinoma. J Thorac Dis 2018; 10: 6452–7.
      Lin S, Yang C, Guo X, Xu Y, Wang L, Wang Z, et al. Simultaneous Uniportal video-assisted thoracic surgery of bilateral pulmonary nodules. J Cardiothorac Surg 2021; 16: 42.
      Mun M, Kohno T Single-stage surgical treatment of synchronous bilateral multiple lung cancers. Ann Thorac Surg 2007; 83: 1146–51.
      Chen TF, Xie CY, Rao BY, Shan SC, Zhang X, Zeng B, et al. Surgical treatment to multiple primary lung cancer patients: A systematic review and meta-analysis. BMC Surg 2019; 19: 185.
      Nie Y, Wang X, Yang F, Zhou Z, Wang J, Chen K Surgical prognosis of synchronous multiple primary lung cancer: Systematic review and meta-analysis. Clin Lung Cancer 2021; 22: 341–50.e3.
      Liu B, Gu C Expert consensus workshop report: Guidelines for preoperative assisted localization of small pulmonary nodules. J Cancer Res Ther 2020; 16: 967–73.
      Jiang G, Chen C, Zhu Y, Xie D, Dai J, Jin K, et al. Shanghai pulmonary hospital experts consensus on the management of ground-glass nodules suspected as lung adenocarcinoma (Version 1). Zhongguo Fei Ai Za Zhi 2018; 21: 147–59. [Chinese].
      Thoracic Surgery Branch of Shanghai Medical Association, Thoracic Surgery Branch of Shanghai Medical Doctor Association, Professional Alliance for Promotion and Improvement of Clinical Ability of General Thoracic Surgery. Expert consensus on the treatment of early-stage multiple primary lung cancers. Zhongguo Xiongxin Xueguan Waike Linchuang Zazhi 2022; 29: 1545–53.
      Qu R, Tu D, Ping W, Cai Y, Zhang N, Fu X Surgical outcomes of one-stage resection for synchronous multiple primary lung adenocarcinomas with no less than three lesions. J Cardiothorac Surg 2021; 16: 265.
      Yao F, Yang H, Zhao H Single-stage bilateral pulmonary resections by video-assisted thoracic surgery for multiple small nodules. J Thorac Dis 2016; 8: 469–75.
      Roberts PF, Straznicka M, Lara PN, Lau DH, Follette DM, Gandara DR, et al. Resection of multifocal non-small cell lung cancer when the bronchioloalveolar subtype is involved. J Thorac Cardiovasc Surg 2003; 126: 1597–602.
      Xu G, Fu X One-stage video-assisted thoracic surgery for bilateral multiple pulmonary nodules. J Thorac Dis 2019; 11: 535–41.
      Huang C, Sun Y, Wu Q, Ma C, Jiao P, Wang Y, et al. Simultaneous bilateral pulmonary resection via single-utility port VATS for multiple pulmonary nodules: A single-center experience of 16 cases. Thorac Cancer 2021; 12: 525–33.
      Haruki T, Aokage K, Miyoshi T, Hishida T, Ishii G, Yoshida J, et al. Mediastinal nodal involvement in patients with clinical stage I non-small-cell lung cancer: Possibility of rational lymph node dissection. J Thorac Oncol 2015; 10: 930–6.
      Koike T, Koike T, Yamato Y, Yoshiya K, Toyabe S Predictive risk factors for mediastinal lymph node metastasis in clinical stage IA non-small-cell lung cancer patients. J Thorac Oncol 2012; 7: 1246–51.
      NCCN Guidelines Non-small cell lung cancer: Version 2.2023. Available from: https://www.nccn.org/professionals/physician_gls/pdf/nscl_blocks.pdf .
      Shao G, Ren W, Feng Z, Peng Z The role of video-assisted thoracoscopic surgery in management of the multiple ground-glass nodules. Indian J Cancer 2015; 52 Suppl 2 e75–9.
      Yu G, Jiang X, Cao H, Huang B Bilateral synchronous multiple lung nodules: Surgical experience from two cases. Saudi J Biol Sci 2018; 25: 971–4.
      Qu R, Ye F, Tu D, Cai Y, Fu X Clinical features and surgical treatment of synchronous multiple primary lung adenocarcinomas with different EGFR mutations. Front Oncol 2022; 11: 785777.
      Qu R, Hao Z, Zhang Y, Bie L, Fu X, Zhang N Single-center experience of simultaneous bilateral uni-portal video-assisted thoracoscopic surgery for multiple ground-glass opacities. J Cardiothorac Surg 2020; 15: 69.
      Liu C, Ma L, Lin F, Mei J, Pu Q, Liao H, et al. Single-staged uniportal VATS major pulmonary resection for bilateral synchronous multiple primary lung cancers. J Thorac Dis 2014; 6: 1315–8.
      Liu B, Ye X Computed tomography-guided percutaneous microwave ablation: A novel perspective to treat multiple pulmonary ground-glass opacities. Thorac Cancer 2020; 11: 2385–8.
      Ahmed M, Solbiati L, Brace CL, Breen DJ, Callstrom MR, Charboneau JW, et al. Image-guided tumor ablation: Standardization of terminology and reporting criteria--A 10-year update. Radiology 2014; 273: 241–60.
      The Ablation Expert Committee of the Chinese Society of Clinical Oncology, the Expert Group on Tumor Ablation Therapy of the Chinese Medical Doctors Association, the Society of Tumor Ablation Therapy of the Chinese Anti-Cancer Association, the Tumor Ablation Committee of the Chinese College of Interventionalists. Clinical Practice Guidelines: Image-Guided Thermal Ablation of Primary and Metastatic Lung Tumors (2021 Edition). Zhonghua Nei Ke Za Zhi 2021; 60: 1088–105. [Chinese].
      Donington J, Ferguson M, Mazzone P, Handy J Jr, Schuchert M, Fernando H, et al. American College of Chest Physicians and Society of Thoracic Surgeons consensus statement for evaluation and management for high-risk patients with stage I non-small cell lung cancer. Chest 2012; 142: 1620–35.
      Howington JA, Blum MG, Chang AC, Balekian AA, Murthy SC Treatment of stage I and II non-small cell lung cancer: Diagnosis and management of lung cancer, 3 rd ed: American College of Chest Physicians evidence-based clinical practice guidelines. Chest 2013; 143: e278S–313S.
      NCCN Clinical Practice Guidelines in Oncology: Lung Cancer Screening (Version 1.2014). NCCN Guidelines for Patients. Available from: www.nccn.org/patients .
      NCCN Clinical Practice Guidelines in Oncology : Lung Cancer Screening (Version 1.2021). NCCN Guidelines for Patients. Available from: www.nccn.org/patients .
      Huang G, Yang X, Li W, Wang J, Han X, Wei Z, et al. A feasibility and safety study of computed tomography-guided percutaneous microwave ablation: A novel therapy for multiple synchronous ground-glass opacities of the lung. Int J Hyperthermia 2020; 37: 414–22.
      Quirk MT, Lee S, Murali N, Genshaft S, Abtin F, Suh R Alternatives to surgery for early-stage non-small cell lung cancer: Thermal ablation. Clin Chest Med 2020; 41: 197–210.
      Xue G, Jia W, Wang G, Zeng Q, Wang N, Li Z, et al. Lung microwave ablation: Post-procedure imaging features and evolution of pulmonary ground-glass nodule-like lung cancer. J Cancer Res Ther 2023; 19: 1654–2.
      Murphy MC, Wrobel MM, Fisher DA, Cahalane AM, Fintelmann FJ Update on image-guided thermal lung ablation: Society guidelines, therapeutic alternatives, and postablation imaging findings. AJR Am J Roentgenol 2022; 219: 471–85.
      Tian H, Bai G, Yang Z, Chen P, Xu J, Liu T, et al. Multiple primary lung cancer: Updates of clinical management and genomic features. Front Oncol 2023; 13: 1034752.
      Austin CA, Mohottige D, Sudore RL, Smith AK, Hanson LC Tools to promote shared decision making in serious illness: A systematic review. JAMA Intern Med 2015; 175: 1213–21.
      Bade B, Gwin M, Triplette M, Wiener RS, Crothers K Comorbidity and life expectancy in shared decision making for lung cancer screening. Semin Oncol 2022. S0093-775400057-4. doi: 10.1053/j.seminoncol. 2022.07.003. (PMID: 10.1053/j.seminoncol.)
      Studts JL, Hirsch EA, Silvestri GA Shared decision-making during a lung cancer screening visit: Is it a barrier or does It bring value?. Chest 2023; 163: 251–4.
      Elwyn G, Brunelli A Shared decision making and its relevance to thoracic surgery. J Thorac Cardiovasc Surg 2023; 165: 1967–70.
      Santos RS, Gupta A, Ebright MI, DeSimone M, Steiner G, Estrada MJ, et al. Electromagnetic navigation to aid radiofrequency ablation and biopsy of lung tumors. Ann Thorac Surg 2010; 89: 265–8.
      Tanabe T, Koizumi T, Tsushima K, Ito M, Kanda S, Kobayashi T, et al. Comparative study of three different catheters for CT imaging-bronchoscopy-guided radiofrequency ablation as a potential and novel interventional therapy for lung cancer. Chest 2010; 137: 890–7.
      Koizumi T, Tsushima K, Tanabe T, Agatsuma T, Yokoyama T, Ito M, et al. Bronchoscopy-guided cooled radiofrequency ablation as a novel intervention therapy for peripheral lung cancer. Respiration 2015; 90: 47–55.
      Xie F, Zheng X, Xiao B, Han B, Herth FJF, Sun J Navigation bronchoscopy-guided radiofrequency ablation for nonsurgical peripheral pulmonary tumors. Respiration 2017; 94: 293–8.
      Bao F, Yu F, Wang R, Chen C, Zhang Y, Lin B Electromagnetic bronchoscopy guided microwave ablation for early stage lung cancer presenting as ground glass nodule. Transl Lung Cancer Res 2021; 10: 3759–70.
      Chan JWY, Lau RWH, Ngai JCL, Tsoi C, Chu CM, Mok TSK, et al. Transbronchial microwave ablation of lung nodules with electromagnetic navigation bronchoscopy guidance-a novel technique and initial experience with 30 cases. Transl Lung Cancer Res 2021; 10: 1608–22.
      Jiang N, Zhang L, Hao Y, Wu X, Zhao Y, Cong B, et al. Combination of electromagnetic navigation bronchoscopy-guided microwave ablation and thoracoscopic resection: An alternative for treatment of multiple pulmonary nodules. Thorac Cancer 2020; 11: 1728–33.
      Zeng C, Fu X, Yuan Z, Hu S, Wang X, Ping W, et al. Application of electromagnetic navigation bronchoscopy-guided microwave ablation in multiple pulmonary nodules: A single-centre study. Eur J Cardiothorac Surg 2022; 62: ezac071.
      Qu R, Tu D, Hu S, Wang Q, Ping W, Hao Z, et al. Electromagnetic navigation bronchoscopy-guided microwave ablation combined with uniportal video-assisted thoracoscopic surgery for multiple ground glass opacities. Ann Thorac Surg 2022; 113: 1307–15.
      Zarogoulidis P, Hohenforst-Schmidt W, Chen W, Porpodis K, Kosmidis C, Kotsakis A, et al. Endobronchial radiofrequency ablation for pulmonary nodules with radial-ebus and navigation: Pros and cons. J Cancer 2023; 14: 1562–70.
      Udelsman BV, Blasberg JD Using the robotic platform in the therapy of multifocal ground glass opacities. J Surg Oncol 2023; 127: 262–8.
      Ravikumar N, Ho E, Wagh A, Murgu S Advanced imaging for robotic bronchoscopy: A review. Diagnostics (Basel) 2023; 13: 990.
      Pritchett MA, Reisenauer JS, Kern R, Wilson DS, Meyers EE, Szapary PO, et al. Novel image-guided flexible-probe transbronchial microwave ablation for stage 1 lung cancer. Respiration 2023; 102: 182–93.
      Liu BD Current status and prospects of the establishment of one-stop management platform for lung nodules and lung cancer. Zhongguo Yishi Jinxiu Zazhi 2022; 45: 769–72. [Chinese].
      Liu B, Zhang Y, Su L, Wang R Treatment options for pulmonary multifocal ground glass opacity type adenocarcinoma: Surgery combine thermal ablation?. J Interv Med 2020; 3: 180–3.
      Harrison OJ, Sarvananthan S, Tamburrini A, Peebles C, Alzetani A Image-guided combined ablation and resection in thoracic surgery for the treatment of multiple pulmonary metastases: A preliminary case series. JTCVS Tech 2021; 9: 156–62.
      Zhou D, Yao T, Huang X, Wu F, Jiang Y, Peng M, et al. Real-world comprehensive diagnosis and “Surgery+X” treatment strategy of early-stage synchronous multiple primary lung cancer. Cancer Med 2023; 12: 12996–3006.
      Radiation Oncology Branch of Chinese Medical Associaation, Radiation Therapy Committee of China Anti-Cancer Association, Radiation Oncologist Branch of Chinese Medical Doctor Association. Chinese expert consensus on stereotactic body radiation therapy for early stage non-small cell lung cancer (2019 Edition). Zhonghua Zhong Liu Za Zhi 2020; 42: 522–30. [Chinese].
      Zhong H, Yao F, Chen QH, Guo JD, Zhang LC, Zhang Y, et al. Clinical diagnosis and treatment of multiple pulmonary nodules. Zhonghua Zhong Liu Za Zhi 2023; 45: 455–63. [Chinese].
      Onishi H, Shioyama Y, Matsumoto Y, Shibamoto Y, Miyakawa A, Suzuki G, et al. Stereotactic body radiotherapy in patients with lung tumors composed of mainly ground-glass opacity. J Radiat Res 2020; 61: 426–30.
      Tomita N, Okuda K, Osaga S, Miyakawa A, Nakanishi R, Shibamoto Y Surgery versus stereotactic body radiotherapy for clinical stage I non-small-cell lung cancer: Propensity score-matching analysis including the ratio of ground glass nodules. Clin Transl Oncol 2021; 23: 638–47.
      Mikami N, Takeda A, Hashimoto A, Takeda T, Kimura Y, Oku Y, et al. CT findings and treatment outcomes of ground-glass opacity predominant lung cancer after stereotactic body radiotherapy. Clin Lung Cancer 2022; 23: 428–37.
      Kim HK, Choi YS, Kim J, Shim YM, Lee KS, Kim K Management of multiple pure ground-glass opacity lesions in patients with bronchioloalveolar carcinoma. J Thorac Oncol 2010; 5: 206–10.
      Kim HS, Lee HJ, Jeon JH, Seong YW, Park IK, Kang CH, et al. Natural history of ground-glass nodules detected on the chest computed tomography scan after major lung resection. Ann Thorac Surg 2013; 96: 1952–7.
      Gao RW, Berry MF, Kunder CA, Khuong AA, Wakelee H, Neal JW, et al. Survival and risk factors for progression after resection of the dominant tumor in multifocal, lepidic-type pulmonary adenocarcinoma. J Thorac Cardiovasc Surg 2017; 154: 2092–9.e2.
      Shimada Y, Ikeda N Gap between clinical and basic researches in multifocal synchronous lung adenocarcinoma studies. J Thorac Dis 2018; 10: S4021–2.
      Mun M, Kohno T Efficacy of thoracoscopic resection for multifocal bronchioloalveolar carcinoma showing pure ground-glass opacities of 20 mm or less in diameter. J Thorac Cardiovasc Surgc 2007; 134: 877–82.
      Bongiolatti S, Corzani R, Borgianni S, Meniconi F, Cipollini F, Gonfiotti A, et al. Long-term results after surgical treatment of the dominant lung adenocarcinoma associated with ground-glass opacities. J Thorac Dis 2018; 10: 4838–48.
    • Publication Date:
      Date Created: 20240829 Date Completed: 20240829 Latest Revision: 20240924
    • Publication Date:
      20240924
    • Accession Number:
      10.4103/jcrt.jcrt_563_24
    • Accession Number:
      39206972