Characterizing human respiratory syncytial virus among children admitted with acute respiratory tract infections from 2019 to 2022.

Publisher: Wiley-Liss Country of Publication: United States NLM ID: 7705876 Publication Model: Print Cited Medium: Internet ISSN: 1096-9071 (Electronic) Linking ISSN: 01466615 NLM ISO Abbreviation: J Med Virol Subsets: MEDLINE

Publication: New York Ny : Wiley-Liss
Original Publication: New York, Liss.

Respiratory Syncytial Virus Infections*/epidemiology ; Respiratory Syncytial Virus Infections*/virology ; Respiratory Syncytial Virus, Human*/genetics ; Respiratory Syncytial Virus, Human*/classification ; Respiratory Syncytial Virus, Human*/isolation & purification ; Phylogeny* ; Respiratory Tract Infections*/virology ; Respiratory Tract Infections*/epidemiology; Humans ; Infant ; Child, Preschool ; Female ; Male ; India/epidemiology ; Seasons ; Hospitalization/statistics & numerical data ; Infant, Newborn ; Genotype

Respiratory syncytial virus is a major causative agent of lower respiratory tract infection in children, especially infants with substantial morbidity and mortality implications. The virus undergoes continuous evolution documented by accumulation of mutations in the glycoprotein gene necessitating vigilant surveillance to provide essential data to epidemiologists and researchers involved in development of vaccines. This study was aimed to perform molecular characterization of respiratory syncytial virus (RSV) among children ≤ 5 years admitted in hospital. In the current study we observed RSV-A (2019 (n = 95) and 2021 (n = 61) seasons) and RSV-B (2022 season (n = 68)). Phylogenetic analysis revealed all RSV-A strains (n = 47) to be GA.2.3.5 and RSV-B (n = 22) were classified as GB.5.0.5a. Selection pressure analysis identified one positive (P274L/V) and one negative site (P230T) in RSV-A, while in RSV-B there was only one negatively selected site (S295). This study spanning over three seasons contributes to RSV evolutionary dynamics in India emphasizing the importance of on-going surveillance to inform effective public health strategies and vaccine development efforts.
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Department of Health Research, India; Jawaharlal Institute Of Postgraduate Medical Education and Research

Keywords: India; RSV; children; epidemiology; molecular characterization

Date Created: 20240829 Date Completed: 20240829 Latest Revision: 20240829

20240902

10.1002/jmv.29896

39206836