Re- Infection Rate of Opisthorchis Viverrini Five Years After Treatment with Praziquantel in High-Risk Area: A Community-Based Study.

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  • Author(s): Saengsawang P;Saengsawang P; Buakate P; Buakate P
  • Source:
    Asian Pacific journal of cancer prevention : APJCP [Asian Pac J Cancer Prev] 2024 Aug 01; Vol. 25 (8), pp. 2679-2684. Date of Electronic Publication: 2024 Aug 01.
  • Publication Type:
    Journal Article
  • Language:
    English
  • Additional Information
    • Source:
      Publisher: Asian Pacific Organization for Cancer Prevention Country of Publication: Thailand NLM ID: 101130625 Publication Model: Electronic Cited Medium: Internet ISSN: 2476-762X (Electronic) Linking ISSN: 15137368 NLM ISO Abbreviation: Asian Pac J Cancer Prev Subsets: MEDLINE
    • Publication Information:
      Original Publication: Bangkok : Asian Pacific Organization for Cancer Prevention,
    • Subject Terms:
      Opisthorchiasis*/epidemiology ; Opisthorchiasis*/drug therapy ; Opisthorchiasis*/parasitology ; Opisthorchis*/drug effects ; Opisthorchis*/isolation & purification ; Praziquantel*/therapeutic use ; Reinfection*/epidemiology ; Anthelmintics*/therapeutic use; Humans ; Animals ; Male ; Female ; Thailand/epidemiology ; Middle Aged ; Follow-Up Studies ; Adult ; Prognosis ; Feces/parasitology ; Cholangiocarcinoma/parasitology ; Cholangiocarcinoma/drug therapy ; Cholangiocarcinoma/epidemiology ; Risk Factors ; Bile Duct Neoplasms/parasitology ; Bile Duct Neoplasms/drug therapy ; Bile Duct Neoplasms/epidemiology ; Cohort Studies ; Prevalence ; Aged
    • Abstract:
      Background: Opisthorchis viverrini (OV)  is a significant public health problem in Thailand, and  OV reinfection poses a serious risk of cholangiocarcinoma with little evidence of a decrease.  While numerous studies have explored OV reinfection and prevalence, most have been limited to short study period. Therefore, there is a need for long-term investigations to gather sufficient evidence.
      Objectives: This study aimed to access the current status of re-infection rates in high- risk areas and to determine associations between factors of and re-infection of OV at 5 years after treatment  with praziquantel.
      Materials and Methods: In total, this study included 457 participants from a cohort study. Each participant was required to answer a questionnaire and undergo stool examination using the formalin ethyl acetate concentration technique. Data were analyzed using descriptive statistics and multiple logistic regression.
      Result: Out of the total 457 participants, 418 (91.5%) successfully completed the questionnaires and underwent stool examinations. Among the participants, 10.8% showed re-infection with OV. Using multivariate analysis, factors significantly associated with reinfection OV included yearly income (OR adj = 2.14, 95%CI = 1.11- 4.12, p-value = 0.022) and past stool examination five years (OR adj = 2.47, 95%CI = 1.13-5.43, p-value = 0.023), respectively.
      Conclusions: Subjects who frequently experience OV reinfection should undergo CCA screening by experts while closely monitoring their raw fish consumption behavior. Moreover, it is essential to implement comprehensive programs aimed at promoting behavioral changes and provide preventive education, with a specific focus on high epidemic areas, to discourage the consumption of raw fish.
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    • Contributed Indexing:
      Keywords: Opisthorchis viverrini; Thailand; praziquantels; re-infection rate
    • Accession Number:
      6490C9U457 (Praziquantel)
      0 (Anthelmintics)
    • Publication Date:
      Date Created: 20240829 Date Completed: 20240829 Latest Revision: 20241024
    • Publication Date:
      20241024
    • Accession Number:
      PMC11495455
    • Accession Number:
      10.31557/APJCP.2024.25.8.2679
    • Accession Number:
      39205565