The uniqueness of human vulnerability to brain aging in great ape evolution.

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  • Additional Information
    • Source:
      Publisher: American Association for the Advancement of Science Country of Publication: United States NLM ID: 101653440 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2375-2548 (Electronic) Linking ISSN: 23752548 NLM ISO Abbreviation: Sci Adv Subsets: MEDLINE
    • Publication Information:
      Original Publication: Washington, DC : American Association for the Advancement of Science, [2015]-
    • Subject Terms:
      Aging*/physiology ; Biological Evolution* ; Brain* ; Pan troglodytes*; Humans ; Animals ; Male ; Female ; Hominidae ; Gray Matter ; Adult ; Aged ; Magnetic Resonance Imaging ; Middle Aged
    • Abstract:
      Aging is associated with progressive gray matter loss in the brain. This spatially specific, morphological change over the life span in humans is also found in chimpanzees, and the comparison between these great ape species provides a unique evolutionary perspective on human brain aging. Here, we present a data-driven, comparative framework to explore the relationship between gray matter atrophy with age and recent cerebral expansion in the phylogeny of chimpanzees and humans. In humans, we show a positive relationship between cerebral aging and cortical expansion, whereas no such relationship was found in chimpanzees. This human-specific association between strong aging effects and large relative cortical expansion is particularly present in higher-order cognitive regions of the ventral prefrontal cortex and supports the "last-in-first-out" hypothesis for brain maturation in recent evolutionary development of human faculties.
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    • Grant Information:
      R01 AG067419 United States AG NIA NIH HHS; R24 NS092988 United States NS NINDS NIH HHS
    • Publication Date:
      Date Created: 20240828 Date Completed: 20240828 Latest Revision: 20241211
    • Publication Date:
      20241211
    • Accession Number:
      PMC11352902
    • Accession Number:
      10.1126/sciadv.ado2733
    • Accession Number:
      39196942