Lineage-based scaling of germline intercellular bridges during oogenesis.

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  • Additional Information
    • Source:
      Publisher: Company Of Biologists Limited Country of Publication: England NLM ID: 8701744 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1477-9129 (Electronic) Linking ISSN: 09501991 NLM ISO Abbreviation: Development Subsets: MEDLINE
    • Publication Information:
      Publication: Cambridge Eng : Company Of Biologists Limited
      Original Publication: [Cambridge] : Company of Biologists, [c1987-
    • Subject Terms:
      Oogenesis*/physiology ; Germ Cells*/cytology ; Cell Lineage*; Animals ; Female ; Drosophila melanogaster ; Drosophila ; Ovum/cytology ; Cell Size
    • Abstract:
      The size of subcellular structures must be tightly controlled to maintain normal cell function. Despite its importance, few studies have determined how the size of organelles or other structures is maintained during development, when cells are growing, dividing and rearranging. The developing Drosophila egg chamber is a powerful model in which to study the relative growth rates of subcellular structures. The egg chamber contains a cluster of 16 germline cells, which are connected through intercellular bridges called ring canals. As the egg chamber grows, the germline cells and the ring canals that connect them increase in size. Here, we demonstrate that ring canal size scaling is related to lineage; the largest, 'first-born' ring canals increase in size at a relatively slower rate than ring canals derived from subsequent mitotic divisions. This lineage-based scaling relationship is maintained even if directed transport is reduced, ring canal size is altered, or in egg chambers with twice as many germline cells. Analysis of lines that produce larger or smaller mature eggs reveals that different strategies could be used to alter final egg size.
      Competing Interests: Competing interests The authors declare no competing or financial interests.
      (© 2024. Published by The Company of Biologists Ltd.)
    • Comments:
      Update of: bioRxiv. 2024 Jul 16:2023.08.18.553876. doi: 10.1101/2023.08.18.553876. (PMID: 37645982)
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    • Grant Information:
      R15 GM099054 United States GM NIGMS NIH HHS; P40 OD018537 United States OD NIH HHS; R15HD084243 United States NH NIH HHS; R15 HD084243 United States HD NICHD NIH HHS; Butler University
    • Contributed Indexing:
      Keywords: Drosophila; Intercellular bridge; Oogenesis; Ring canal
    • Publication Date:
      Date Created: 20240827 Date Completed: 20240827 Latest Revision: 20240912
    • Publication Date:
      20240912
    • Accession Number:
      PMC11385318
    • Accession Number:
      10.1242/dev.202676
    • Accession Number:
      39190553