Progressive alterations of resting-state hypothalamic dysconnectivity in schizophrenia.

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  • Additional Information
    • Source:
      Publisher: Pergamon Press Country of Publication: England NLM ID: 8211617 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1878-4216 (Electronic) Linking ISSN: 02785846 NLM ISO Abbreviation: Prog Neuropsychopharmacol Biol Psychiatry Subsets: MEDLINE
    • Publication Information:
      Original Publication: Oxford ; New York : Pergamon Press, c1982-
    • Subject Terms:
      Schizophrenia*/physiopathology ; Schizophrenia*/diagnostic imaging ; Schizophrenia*/drug therapy ; Hypothalamus*/physiopathology ; Hypothalamus*/diagnostic imaging ; Magnetic Resonance Imaging* ; Antipsychotic Agents*/therapeutic use ; Antipsychotic Agents*/pharmacology; Humans ; Male ; Female ; Adult ; Young Adult ; Rest/physiology ; Disease Progression ; Neural Pathways/physiopathology ; Neural Pathways/diagnostic imaging ; Middle Aged
    • Abstract:
      Background: The hypothalamus may be involved in the pathogenesis of schizophrenia. Investigating hypothalamus dysfunction in schizophrenia and probing how it is related to symptoms and responds to antipsychotic medication is crucial for understanding the potential mechanism of hypothalamus dysfunction under the long-term illness.
      Methods: We recruited 216 patients with schizophrenia, including 140 antipsychotic-naïve first-episode patients (FES, including 44 patients with 1-year follow-up data), 76 chronically treated schizophrenia (CTS), and 210 healthy controls (HC). Hypothalamic seed-based functional connectivity (FC) was calculated and compared among the FES, CTS, and HC groups using analysis of covariance. Exploratory analysis was conducted between the FES patients at baseline and after 1-year follow-up. Significantly altered hypothalamic FCs were then related to clinical symptomology, while age- and illness-related regression analyses were also conducted and compared between diagnostic groups.
      Results: The FES patients showed decreased hypothalamic FCs with the midbrain and right thalamus, whereas the CTS patients showed more severe decreased hypothalamic FCs with the midbrain, right thalamus, left putamen, right caudate, and bilateral anterior cingulate cortex compared to HCs. These abnormalities were not correlated to the symptomology or illness duration, or not reversed by the antipsychotic treatment. Age-related hypothalamic FC decrease was also identified in the abovementioned regions, and a faster age-related decline of the hypothalamic FC was observed with the left putamen and bilateral anterior cingulate cortex.
      Conclusion: Age-related hypothalamic FC decrease extends the functional alterations that characterize the neurodegenerative nature of schizophrenia. Future studies are required to further probe the hormonal or endocrinal underpinnings of such alterations and trace the precise progressive trajectories.
      Competing Interests: Declaration of competing interest Dr. Wenjing Zhang consults to VeraSci. The remaining authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
      (Copyright © 2024 Elsevier Inc. All rights reserved.)
    • Contributed Indexing:
      Keywords: Functional connectivity; Functional magnetic resonance imaging; Hypothalamus; Schizophrenia
    • Accession Number:
      0 (Antipsychotic Agents)
    • Publication Date:
      Date Created: 20240824 Date Completed: 20240915 Latest Revision: 20240915
    • Publication Date:
      20240916
    • Accession Number:
      10.1016/j.pnpbp.2024.111127
    • Accession Number:
      39181307