Biocide physically cross-linked hydrogels based on carrageenan and guanidinium polyampholytes for wound healing applications.

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  • Additional Information
    • Source:
      Publisher: Elsevier Country of Publication: Netherlands NLM ID: 7909578 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1879-0003 (Electronic) Linking ISSN: 01418130 NLM ISO Abbreviation: Int J Biol Macromol Subsets: MEDLINE
    • Publication Information:
      Publication: Amsterdam : Elsevier
      Original Publication: Guildford, Eng., IPC Science and Technology Press.
    • Subject Terms:
      Carrageenan*/chemistry ; Hydrogels*/chemistry ; Hydrogels*/pharmacology ; Wound Healing*/drug effects ; Guanidine*/chemistry ; Guanidine*/pharmacology ; Escherichia coli*/drug effects ; Staphylococcus aureus*/drug effects ; Drug Liberation* ; Anti-Bacterial Agents*/pharmacology ; Anti-Bacterial Agents*/chemistry; Ampicillin/pharmacology ; Ampicillin/chemistry ; Disinfectants/pharmacology ; Disinfectants/chemistry ; Microbial Sensitivity Tests ; Polymers/chemistry ; Hydrogen-Ion Concentration
    • Abstract:
      Over last years, hydrogels based on natural polymers have attracted considerable interest as materials for wound healing. Herein, hydrogel films based on kappa-carrageenan and guanidinium polyampholytes were prepared by the in situ physical cross-linking with potassium chloride and borax, respectively. The polyampholytes were obtained by a free radical copolymerization of 2,2-diallyl-1,1,3,3-tetraethylguanidinium chloride and unsaturated acids. To characterize the composite films, NMR, FTIR, SEM, TGA, XRD, element analysis and tensile test were used. Ampicillin was incorporated into the hydrogels to enhance wound healing potential. The healing-related characteristics, including swelling ratio, drug release and antimicrobial activity, were assessed. The equilibrium swelling ratios were in the range of 3.9-6.5 depending on the polyampholyte composition. According to the in vitro ampicillin release studies, 30-43 % of ampicillin was released from the hydrogels after 5 h at 37 °C and pH 7.4, with drug release being temperature and pH dependent. The ampicillin-loaded films showed a remarkable antimicrobial effect. The inhibition sizes for Escherichia coli and Staphylococcus aureus were 1.10-1.85 and 1.95-2.60 cm, respectively. Although the bi-polymeric hydrogels were thoroughly characterized, with the in vitro study of their biocidal effects carried out in this work, the in vivo drug release assessment needs to be further explored.
      Competing Interests: Declaration of competing interest The authors declare the following financial interests/personal relationships which may be considered as potential competing interests: Marina Gorbunova reports financial support was provided by Russian Science Foundation. If there are other authors, they declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
      (Copyright © 2024 Elsevier B.V. All rights reserved.)
    • Contributed Indexing:
      Keywords: Carrageenan; Hydrogel; Polyampholyte
    • Accession Number:
      9000-07-1 (Carrageenan)
      0 (Hydrogels)
      JU58VJ6Y3B (Guanidine)
      0 (Anti-Bacterial Agents)
      7C782967RD (Ampicillin)
      0 (Disinfectants)
      0 (Polymers)
    • Publication Date:
      Date Created: 20240823 Date Completed: 20240917 Latest Revision: 20240917
    • Publication Date:
      20240917
    • Accession Number:
      10.1016/j.ijbiomac.2024.134948
    • Accession Number:
      39178769