Tests of abnormal gaze behavior increase the accuracy of mild cognitive impairment assessments.

Item request has been placed! ×
Item request cannot be made. ×
loading   Processing Request
Read More Add to Saved list
  • Additional Information
    • Source:
      Publisher: Nature Publishing Group Country of Publication: England NLM ID: 101563288 Publication Model: Electronic Cited Medium: Internet ISSN: 2045-2322 (Electronic) Linking ISSN: 20452322 NLM ISO Abbreviation: Sci Rep Subsets: MEDLINE
    • Publication Information:
      Original Publication: London : Nature Publishing Group, copyright 2011-
    • Subject Terms:
      Cognitive Dysfunction*/diagnosis ; Cognitive Dysfunction*/physiopathology ; Fixation, Ocular*/physiology; Humans ; Female ; Male ; Aged ; Eye-Tracking Technology ; Neuropsychological Tests ; ROC Curve ; Middle Aged ; Case-Control Studies ; Aged, 80 and over
    • Abstract:
      Tests to detect mild cognitive impairment (MCI) should have high sensitivity and accuracy. Previously, we reported on a cognitive composition test (CCT) that we developed to detect MCI. In this study, we compared gaze behavior parameters, namely, gaze fixation duration and gaze-shift frequency, during the CCT in participants with MCI and healthy controls (HC) to determine whether these parameters would accurately detect MCI in older adults. Participants performed CCT-A, -B, and -C tasks with varying difficulty levels while wearing eye-tracking devices. Performance time, gaze fixation duration, and gaze-shift frequency were analyzed. Receiver operating characteristic curve analysis was performed to assess the identification accuracy. The MCI group was significantly slower in completing the CCT-C task and had a higher gaze-shift frequency into both the sample object space and workspace than the HC group. Gaze fixation duration in the sample object space increased in the MCI group as the CCT became difficult. Our findings indicated that combining the CCT with performance time and gaze pattern improved the accuracy of distinguishing between individuals with and without MCI and that patients with MCI have abnormal gaze behavior during cognitive tasks. Therefore, evaluation of gaze parameters may improve the accuracy of identifying patients with MCI.
      (© 2024. The Author(s).)
    • References:
      Behav Brain Res. 2017 Mar 30;322(Pt B):351-361. (PMID: 27616343)
      Neuroepidemiology. 2009;33(2):103-10. (PMID: 19494551)
      J Thorac Dis. 2019 Mar;11(Suppl 4):S574-S584. (PMID: 31032076)
      Front Aging Neurosci. 2023 Mar 21;15:1123456. (PMID: 37025964)
      PLoS One. 2011;6(12):e28928. (PMID: 22174928)
      JAMA. 2023 Aug 8;330(6):512-527. (PMID: 37459141)
      N Engl J Med. 2023 Jan 5;388(1):9-21. (PMID: 36449413)
      Neurosci Res. 2021 Oct;171:62-66. (PMID: 33785409)
      Lancet. 2017 Dec 16;390(10113):2673-2734. (PMID: 28735855)
      Arch Clin Neuropsychol. 2008 Mar;23(2):129-37. (PMID: 18178372)
      Front Psychol. 2023 Jul 20;14:1197567. (PMID: 37546488)
      Behav Brain Res. 2011 Aug 10;221(2):334-40. (PMID: 20060018)
      J Alzheimers Dis. 2018;63(1):185-194. (PMID: 29614644)
      Neurocase. 2005 Feb;11(1):80-4. (PMID: 15804928)
      Lancet. 2015 Jun 6;385(9984):2255-63. (PMID: 25771249)
      Brain. 2001 Apr;124(Pt 4):739-56. (PMID: 11287374)
      Neuropsychiatr Dis Treat. 2014 Jul 09;10:1273-85. (PMID: 25031536)
      Percept Mot Skills. 2002 Jun;94(3 Pt 2):1283-91. (PMID: 12186250)
      N Engl J Med. 2021 May 6;384(18):1691-1704. (PMID: 33720637)
      Cortex. 2005 Aug;41(4):512-9. (PMID: 16042027)
      Front Neurol. 2010 Nov 22;1:138. (PMID: 21212841)
      Neurocase. 2010 Oct;16(5):408-17. (PMID: 20401803)
      Psychogeriatrics. 2020 Sep;20(5):802-804. (PMID: 32743858)
      J Am Geriatr Soc. 2003 May;51(5 Suppl Dementia):S281-8. (PMID: 12801384)
      Psychiatry Res. 2015 Sep 30;229(1-2):470-8. (PMID: 26228165)
      Neuropsychologia. 2002;40(12):1849-57. (PMID: 12207983)
      Trends Cogn Sci. 2005 Apr;9(4):188-94. (PMID: 15808501)
      J Clin Med. 2023 Feb 02;12(3):. (PMID: 36769849)
      Neuropsychology. 2000 Jul;14(3):398-408. (PMID: 10928743)
      Biomed Res Int. 2015;2015:748212. (PMID: 26550575)
      Behav Res Methods. 2007 May;39(2):175-91. (PMID: 17695343)
      J Am Med Dir Assoc. 2017 Sep 1;18(9):808.e1-808.e6. (PMID: 28711424)
      Neuroimage Clin. 2016 Nov 17;13:82-88. (PMID: 27942450)
      Cogn Psychol. 1980 Jan;12(1):97-136. (PMID: 7351125)
      Ageing Res Rev. 2017 Nov;40:75-83. (PMID: 28912076)
      Front Neurosci. 2023 Jun 15;17:1171417. (PMID: 37397453)
      Neuropsychology. 2011 Mar;25(2):237-48. (PMID: 21381828)
      Brain. 1999 Mar;122 ( Pt 3):383-404. (PMID: 10094249)
      Dementia. 1995 Sep-Oct;6(5):264-8. (PMID: 8528373)
    • Grant Information:
      21K17418 JSPS KAKENHI
    • Publication Date:
      Date Created: 20240822 Date Completed: 20240822 Latest Revision: 20240825
    • Publication Date:
      20240826
    • Accession Number:
      PMC11341758
    • Accession Number:
      10.1038/s41598-024-70657-3
    • Accession Number:
      39174695