Enhancing Root Canal Therapy with NIR-II Semiconducting Polymer AIEgen and Low-Concentration Sodium Hypochlorite Synergy.

Publisher: Wiley-VCH Country of Publication: Germany NLM ID: 101581613 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2192-2659 (Electronic) Linking ISSN: 21922640 NLM ISO Abbreviation: Adv Healthc Mater Subsets: MEDLINE

Original Publication: Weinheim : Wiley-VCH, 2012-

Sodium Hypochlorite*/pharmacology ; Sodium Hypochlorite*/chemistry ; Enterococcus faecalis*/drug effects ; Root Canal Therapy*/methods ; Polymers*/chemistry ; Polymers*/pharmacology; Humans ; Staphylococcus aureus/drug effects ; Nanoparticles/chemistry ; Semiconductors ; Anti-Bacterial Agents/pharmacology ; Anti-Bacterial Agents/chemistry ; Streptococcus mutans/drug effects ; Dental Pulp Cavity/drug effects ; Dental Pulp Cavity/microbiology

Despite significant efforts to eliminate bacterial biofilm within root canals, achieving effective disinfection remains challenging due to the complex anatomy and limitations of disinfectants. In this study, a second near-infrared (NIR-II) semiconducting polymer with aggregation-induced emission (AIE) properties, named PIDT-TBT, is deliberately designed and synthesized. This proposes an AIE luminogen-based sterilization strategy in synergy with a low concentration of sodium hypochlorite (NaClO). Water-dispersible PIDT-TBT nanoparticles (NPs) are prepared, demonstrating good biocompatibility, as well as photothermal and photodynamic properties. Subsequent antibacterial tests show that PIDT-TBT NPs exhibit excellent bactericidal effects against three bacterial strains: Staphylococcus aureus, Streptococcus mutans, and Enterococcus faecalis, upon 808 nm laser irradiation. In synergy with a low concentration of NaClO (0.5%) solution, PIDT-TBT NPs significantly improves the outcome of root canal treatment under 808 nm laser irradiation in a human extracted tooth root canal infection model. Additionally, it is found that PIDT-TBT NPs combine with a low concentration of NaClO solution could safely dissolve dentin debris and further increase the efficiency of root canal preparation by altering the elemental composition of the inner root canal wall.
(© 2024 Wiley‐VCH GmbH.)

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TJYXZDXK-078D Tianjin Key Medical Discipline (Specialty) Construction Project; 52173285 Innovative Research Group Project of the National Natural Science Foundation of China

Keywords: NIR‐II semiconducting polymer; aggregation‐induced emission; photodynamic therapy; photothermal therapy; root canal treatment

DY38VHM5OD (Sodium Hypochlorite)
0 (Polymers)
0 (Anti-Bacterial Agents)

Date Created: 20240822 Date Completed: 20241204 Latest Revision: 20241204

20241204

10.1002/adhm.202401434

39171782