Cu 2 Cl(OH) 3 nanozyme-based colorimetric sensor array for phosphates discrimination and disease identification.

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  • Additional Information
    • Source:
      Publisher: Elsevier Country of Publication: Netherlands NLM ID: 2984816R Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-3573 (Electronic) Linking ISSN: 00399140 NLM ISO Abbreviation: Talanta Subsets: MEDLINE
    • Publication Information:
      Publication: Amsterdam : Elsevier
      Original Publication: Oxford : Pergamon Press
    • Subject Terms:
      Colorimetry*/methods ; Phosphates*/chemistry ; Phosphates*/analysis ; Copper*/chemistry ; Copper*/analysis; Humans ; Nanostructures/chemistry
    • Abstract:
      The identification of phosphates holds significant importance in many physiological processes and disease diagnosis, and traditional detection techniques struggle to simultaneously detect and distinguish phosphates. The complexity of synthesizing sensing units restricts the construction of sensor arrays as well. In this study, a bifunctional dicopper chloride trihydroxide (Cu 2 Cl(OH) 3 ) nanozyme with conspicuous laccase- and peroxidase-like activities has been synthesized in basic deep eutectic solvents (DES). Exploiting the various regulatory impacts of multiple phosphates on the dual-enzyme mimicking activities, the sensor array based on the laccase mimic and peroxidase mimic properties of Cu 2 Cl(OH) 3 was designed, which has been successfully harnessed for the identification of eight phosphates (ATP, ADP, AMP, PPi, Pi, GTP, GDP, and GMP). This approach streamlines the creation of sensor arrays. Besides, the three simulated actual samples (healthy individuals, moderately ill patients, and severely ill patients) have been accurately distinguished. This work makes a substantial contribution to enhancing the highly effective construction of array channels and promoting discrimination of phosphates in intricate samples.
      Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
      (Copyright © 2024 Elsevier B.V. All rights reserved.)
    • Contributed Indexing:
      Keywords: Colorimetric sensor array; Deep eutectic solvents; Discrimination; Nanozyme; Phosphates
    • Accession Number:
      0 (Phosphates)
      789U1901C5 (Copper)
    • Publication Date:
      Date Created: 20240821 Date Completed: 20240917 Latest Revision: 20240917
    • Publication Date:
      20250114
    • Accession Number:
      10.1016/j.talanta.2024.126724
    • Accession Number:
      39167938