From rest to repair: Safeguarding genomic integrity in quiescent cells.

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  • Author(s): Leung CWB;Leung CWB; Wall J; Wall J; Esashi F; Esashi F
  • Source:
    DNA repair [DNA Repair (Amst)] 2024 Oct; Vol. 142, pp. 103752. Date of Electronic Publication: 2024 Aug 20.
  • Publication Type:
    Journal Article; Review
  • Language:
    English
  • Additional Information
    • Source:
      Publisher: Elsevier Country of Publication: Netherlands NLM ID: 101139138 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1568-7856 (Electronic) Linking ISSN: 15687856 NLM ISO Abbreviation: DNA Repair (Amst) Subsets: MEDLINE
    • Publication Information:
      Original Publication: Amsterdam ; New York : Elsevier, c2002-
    • Subject Terms:
      DNA Repair* ; Genomic Instability* ; DNA Damage*; Humans ; Animals ; Resting Phase, Cell Cycle ; Cell Cycle ; DNA Replication
    • Abstract:
      Quiescence is an important non-pathological state in which cells pause cell cycle progression temporarily, sometimes for decades, until they receive appropriate proliferative stimuli. Quiescent cells make up a significant proportion of the body, and maintaining genomic integrity during quiescence is crucial for tissue structure and function. While cells in quiescence are spared from DNA damage associated with DNA replication or mitosis, they are still exposed to various sources of endogenous DNA damage, including those induced by normal transcription and metabolism. As such, it is vital that cells retain their capacity to effectively repair lesions that may occur and return to the cell cycle without losing their cellular properties. Notably, while DNA repair pathways are often found to be downregulated in quiescent cells, emerging evidence suggests the presence of active or differentially regulated repair mechanisms. This review aims to provide a current understanding of DNA repair processes during quiescence in mammalian systems and sheds light on the potential pathological consequences of inefficient or inaccurate repair in quiescent cells.
      Competing Interests: Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
      (Copyright © 2024 The Authors. Published by Elsevier B.V. All rights reserved.)
    • Contributed Indexing:
      Keywords: DNA repair; Genome stability; Metabolism; Quiescence; Transcription
    • Publication Date:
      Date Created: 20240821 Date Completed: 20240912 Latest Revision: 20240912
    • Publication Date:
      20240913
    • Accession Number:
      10.1016/j.dnarep.2024.103752
    • Accession Number:
      39167890