Non-Enzymatic Detection of Cardiac Troponin-I with Graphene Oxide Quenched Fluorescent Iron Nanoclusters (FeNCs).

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  • Additional Information
    • Source:
      Publisher: Wiley-VCH Country of Publication: Germany NLM ID: 9513783 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1521-3765 (Electronic) Linking ISSN: 09476539 NLM ISO Abbreviation: Chemistry Subsets: MEDLINE
    • Publication Information:
      Original Publication: Weinheim, Germany : Wiley-VCH
    • Subject Terms:
      Graphite*/chemistry ; Troponin I*/blood ; Troponin I*/analysis ; Fluorescence Resonance Energy Transfer*/methods ; Fluorescent Dyes*/chemistry ; Limit of Detection* ; Iron*/chemistry; Humans ; Hydrogen Peroxide/chemistry ; Biomarkers/blood ; Biosensing Techniques/methods
    • Abstract:
      Cardiac troponin I (cTnI) is the most resorted biomarker for the detection of cardiovascular disease (CVD). The means of rapid quantification of cTnI levels in the blood can substantially minimize the risk of acute myocardial infarction and heart failure. A sensor for the non-enzymatic evaluation of cardiac troponin-I has been developed using fluorescent iron nanoclusters via a one-pot synthesis employing (BSA) as the template and reducing agent, and hydrogen peroxide as the additive. The fluorescence of Iron Nanocluster is quenched with graphene oxide (GO) via fluorescence resonance energy transfer (FRET) between conjugate iron nanoclusters and graphene oxide. The sensor shows a low detection limit of 0.011 ng/mL. The benefits of utilizing a non-enzymatic probe for detecting cardiac troponin I is that it avoids the need for enzymes and hence is economical, stable, and less impacted by environmental conditions such as temperature and pH. Non-enzymatic probes are more useful for clinical use since they are more stable and have a longer shelf life. The developed non-enzymatic probes are also highly selective and sensitive to the target analyte, making them suitable for the direct detection of cardiac troponin I in actual biological samples.
      (© 2024 Wiley-VCH GmbH.)
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    • Grant Information:
      RBI0072494658807 Indian Council for Cultural Relations
    • Contributed Indexing:
      Keywords: Acute myocardial infarction (AMI); Cardiac biomarker; Graphene oxide; Iron nanoclusters (BSA@FeNCs); Non-enzymatic probe
    • Accession Number:
      7782-42-5 (Graphite)
      0 (Troponin I)
      0 (graphene oxide)
      0 (Fluorescent Dyes)
      E1UOL152H7 (Iron)
      BBX060AN9V (Hydrogen Peroxide)
      0 (Biomarkers)
    • Publication Date:
      Date Created: 20240821 Date Completed: 20241105 Latest Revision: 20241108
    • Publication Date:
      20241108
    • Accession Number:
      10.1002/chem.202401867
    • Accession Number:
      39166354