Chimerism and mosaicism shape our physical constitution and impact medical conditions.

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  • Author(s): Flegel WA;Flegel WA;Flegel WA
  • Source:
    British journal of haematology [Br J Haematol] 2024 Oct; Vol. 205 (4), pp. 1262-1264. Date of Electronic Publication: 2024 Aug 20.
  • Publication Type:
    Journal Article
  • Language:
    English
  • Additional Information
    • Source:
      Publisher: Wiley-Blackwell Country of Publication: England NLM ID: 0372544 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1365-2141 (Electronic) Linking ISSN: 00071048 NLM ISO Abbreviation: Br J Haematol Subsets: MEDLINE
    • Publication Information:
      Publication: Oxford : Wiley-Blackwell
      Original Publication: Oxford : Blackwell Scientific Publications
    • Subject Terms:
      Mosaicism* ; Chimerism* ; ABO Blood-Group System*/genetics; Humans
    • Abstract:
      ABO blood group discrepancies in healthy individuals were caused by body-wide chimerism and mosaicism. They can be evaluated with new diagnostic options for disease-related cell clones that are typically associated with mosaicism. The observations raise the attention for sporadic mixed-field observations of any blood group antigen. Commentary on: Dauber et al. Body-wide chimerism and mosaicism are predominant causes of naturally occurring ABO discrepancies. Br J Haematol 2024; 205:1188-1196.
      (Published 2024. This article is a U.S. Government work and is in the public domain in the USA. British Journal of Haematology published by British Society for Haematology and John Wiley & Sons Ltd.)
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    • Grant Information:
      ZIC CL002128 United States ImNIH Intramural NIH HHS
    • Contributed Indexing:
      Keywords: blood group; cell lineage; red cells; single‐cell genomics; somatic mutation
    • Accession Number:
      0 (ABO Blood-Group System)
    • Publication Date:
      Date Created: 20240820 Date Completed: 20241017 Latest Revision: 20241019
    • Publication Date:
      20241019
    • Accession Number:
      PMC11486570
    • Accession Number:
      10.1111/bjh.19705
    • Accession Number:
      39162344