Differentiating Definite and Probable Ménière Disease: A Comprehensive Evaluation of Audio-Vestibular Function Testing Combined with Inner Ear MRI.

Publisher: Lippincott Williams & Wilkins Country of Publication: United States NLM ID: 100961504 Publication Model: Print Cited Medium: Internet ISSN: 1537-4505 (Electronic) Linking ISSN: 15317129 NLM ISO Abbreviation: Otol Neurotol Subsets: MEDLINE

Original Publication: Hagerstown, MD : Lippincott Williams & Wilkins, c2001-

Meniere Disease*/diagnostic imaging ; Meniere Disease*/diagnosis ; Magnetic Resonance Imaging*/methods ; Ear, Inner*/diagnostic imaging ; Ear, Inner*/physiopathology ; Vestibular Function Tests*/methods; Humans ; Male ; Female ; Middle Aged ; Adult ; Aged ; Diagnosis, Differential ; Audiometry, Pure-Tone/methods ; Caloric Tests ; Gadolinium ; Sensitivity and Specificity

Objectives: To evaluate the differences between audio-vestibular function testing and inner ear gadolinium magnetic resonance imaging (MRI) in distinguishing definite Ménière disease (DMD) and probable Ménière disease (PMD), and to provide a reference for early clinical diagnosis and intervention.
Methods: A total of 116 patients diagnosed with DMD (n = 80) and PMD (n = 36) were enrolled. The differences in the results of pure tone audiometry, caloric test, and tympanic injection of gadolinium for contrast-enhanced MRI between the two groups were compared and analyzed. Parameters that could differentiate between the two conditions were identified, and the sensitivity and specificity and the area under the curve (AUC) of individual and combined indices in the differential diagnosis of DMD and PMD were evaluated.
Results: The hearing threshold and hearing asymmetry rate of the DMD group were significantly higher than those of the PMD group (p < 0.001), 98.8% and 30.6%, respectively. The abnormal rates of canal paresis (CP) and severity of endolymphatic hydrops in the DMD group were higher than those in the PMD group (p < 0.05). When combined with high-frequency hearing thresholds, hearing asymmetry, hearing curve type, endolymphatic hydrops, and abnormal CP, the diagnostic accuracy of DMD was improved compared to using high-frequency alone (p < 0.05).
Conclusion: This study showed that PMD and DMD may represent two different stages in the development of MD disease. The comprehensive assessment of audio-vestibular function testing and inner ear MRI proves beneficial for early diagnosis, potentially contributing to the preservation of inner ear function.
Competing Interests: Conflict of interest statement: The authors have no relevant financial or nonfinancial interests to disclose.
(Copyright © 2024, Otology & Neurotology, Inc.)

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AU0V1LM3JT (Gadolinium)

Date Created: 20240814 Date Completed: 20240814 Latest Revision: 20240814

20240815

10.1097/MAO.0000000000004282

39142314