Novel self-assembled micelles of dual-modified dextrin with pH responsiveness via grafted octenyl succinic anhydride and cysteamine for curcumin delivery.

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  • Additional Information
    • Source:
      Publisher: Elsevier Applied Science Publishers Country of Publication: England NLM ID: 7702639 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-7072 (Electronic) Linking ISSN: 03088146 NLM ISO Abbreviation: Food Chem Subsets: MEDLINE
    • Publication Information:
      Publication: Barking : Elsevier Applied Science Publishers
      Original Publication: Barking, Eng., Applied Science Publishers.
    • Subject Terms:
      Curcumin*/chemistry ; Micelles* ; Drug Carriers*/chemistry ; Dextrins*/chemistry ; Cysteamine*/chemistry; Hydrogen-Ion Concentration ; Succinic Anhydrides/chemistry ; Drug Delivery Systems ; Particle Size
    • Abstract:
      In this study, a novel dextrin-based micelle (OSAD-SH), dual-modified with octenyl succinic anhydride (OSA) and cysteamine, was developed to address the acid instability issues of micelle modified only by OSA and designed for curcumin delivery. Three amphiphilic OSAD-SH polymers with different free sulfhydryl content were first synthesized. The study demonstrated that OSAD-SH micelles exhibited strong self-assembly properties, appearing as spheres with diameters ranging from 92.41 to 194.20 nm. Blank micelles showed good dilution resistance, as well as stability against acid, thermal, and ionic strength. The curcumin encapsulated by the micelles was in an amorphous state. In vitro release experiment demonstrated that curcumin released from OSAD-SH micelles exhibited pH responsiveness. The Ritger-Peppas model effectively predicted the release behavior of curcumin, which followed a super case-II transport. The OSAD-SH micelle will be a promising nanocarrier for improving the physicochemical properties of curcumin in food fields.
      Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
      (Copyright © 2024. Published by Elsevier Ltd.)
    • Contributed Indexing:
      Keywords: Curcumin delivery; Cysteamine; Dual-modified dextrin micelles; Octenyl succinic anhydride; pH responsiveness
    • Accession Number:
      IT942ZTH98 (Curcumin)
      0 (Micelles)
      0 (Drug Carriers)
      0 (Dextrins)
      5UX2SD1KE2 (Cysteamine)
      0 (Succinic Anhydrides)
      6RF4O17Z8J (succinic anhydride)
    • Publication Date:
      Date Created: 20240814 Date Completed: 20240905 Latest Revision: 20240905
    • Publication Date:
      20240905
    • Accession Number:
      10.1016/j.foodchem.2024.140748
    • Accession Number:
      39142209