High serum levels of reactive nitrogen species and low total antioxidant capacity in patients with resistant hypertension compared to those in age- gender matched healthy controls, controlled hypertension and follow up with propranolol treatment in the extended APPROPRIATE trial.

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  • Additional Information
    • Source:
      Publisher: Biomed Central Country of Publication: England NLM ID: 101462768 Publication Model: Electronic Cited Medium: Internet ISSN: 1756-0500 (Electronic) Linking ISSN: 17560500 NLM ISO Abbreviation: BMC Res Notes Subsets: MEDLINE
    • Publication Information:
      Original Publication: London : Biomed Central, 2008.
    • Subject Terms:
      Hypertension*/drug therapy ; Hypertension*/blood ; Hypertension*/physiopathology ; Antioxidants*/metabolism ; Propranolol*/therapeutic use ; Propranolol*/pharmacology ; Antihypertensive Agents*/therapeutic use ; Reactive Nitrogen Species*/blood ; Reactive Nitrogen Species*/metabolism; Humans ; Female ; Male ; Middle Aged ; Case-Control Studies ; Blood Pressure/drug effects ; Adult ; Follow-Up Studies ; Aged
    • Abstract:
      Objectives: To perform a comparative analysis of the extended APPROPRIATE trial of measures of reactive nitrogen species and antioxidant capacity in patients having resistant hypertension with controlled hypertension and healthy controls.
      Results: Mean serum NO 2 - and NOx levels were significantly lower and mean AOC was significantly higher in patients with controlled hypertension (n = 38) and healthy controls (n = 38) compared to resistant hypertension (RHTN) patients (n = 40) at the pre-intervention stage (p < 0.001). The serum NO 2 -, NOx and AOC levels of both controlled hypertension and healthy controls were comparable to those of the RHTN patients following treatment with propranolol (n = 18). Considering all samples (n = 114) we noted that there were significant weak and moderate positive correlations between NO 2 - levels with systolic blood pressure (SBP) and diastolic blood pressure (DBP) (r = 0.396, p < 0.001 and r = 0.292, p = 0.004) as well as total NOx levels with SBP and DBP (r = 0.636 and r = 0.480 respectively, p < 0.001). Conversely, there was a significant negative correlation between AOC levels with SBP and DBP (r= -0.846 and r = -0.626 respectively, p < 0.001).
      (© 2024. The Author(s).)
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    • Contributed Indexing:
      Keywords: Anti-oxidant capacity; Oxidative stress; Reactive nitrogen species; Resistant hypertension, Sri Lanka
    • Accession Number:
      0 (Antioxidants)
      9Y8NXQ24VQ (Propranolol)
      0 (Antihypertensive Agents)
      0 (Reactive Nitrogen Species)
    • Publication Date:
      Date Created: 20240813 Date Completed: 20240814 Latest Revision: 20240816
    • Publication Date:
      20240816
    • Accession Number:
      PMC11323664
    • Accession Number:
      10.1186/s13104-024-06884-8
    • Accession Number:
      39138542