Prevention of Pregnancy Complications Using a Multimodal Lifestyle, Screening, and Medical Model.

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  • Additional Information
    • Source:
      Publisher: MDPI AG Country of Publication: Switzerland NLM ID: 101606588 Publication Model: Electronic Cited Medium: Print ISSN: 2077-0383 (Print) Linking ISSN: 20770383 NLM ISO Abbreviation: J Clin Med Subsets: PubMed not MEDLINE
    • Publication Information:
      Original Publication: Basel, Switzerland : MDPI AG, [2012]-
    • Abstract:
      Prevention of pregnancy complications related to the "great obstetrical syndromes" (preeclampsia, fetal growth restriction, spontaneous preterm labor, and stillbirth) is a global research and clinical management priority. These syndromes share many common pathophysiological mechanisms that may contribute to altered placental development and function. The resulting adverse pregnancy outcomes are associated with increased maternal and perinatal morbidity and mortality and increased post-partum risk of cardiometabolic disease. Maternal nutritional and environmental factors are known to play a significant role in altering bidirectional communication between fetal-derived trophoblast cells and maternal decidual cells and contribute to abnormal placentation. As a result, lifestyle-based interventions have increasingly been recommended before, during, and after pregnancy, in order to reduce maternal and perinatal morbidity and mortality and decrease long-term risk. Antenatal screening strategies have been developed following extensive studies in diverse populations. Multivariate preeclampsia screening using a combination of maternal, biophysical, and serum biochemical markers is recommended at 11-14 weeks' gestation and can be performed at the same time as the first-trimester ultrasound and blood tests. Women identified as high-risk can be offered prophylactic low dose aspirin and monitored with angiogenic factor assessment from 22 weeks' gestation, in combination with clinical assessment, serum biochemistry, and ultrasound. Lifestyle factors can be reassessed during counseling related to antenatal screening interventions. The integration of lifestyle interventions, pregnancy screening, and medical management represents a conceptual advance in pregnancy care that has the potential to significantly reduce pregnancy complications and associated later life cardiometabolic adverse outcomes.
    • References:
      BMC Pregnancy Childbirth. 2024 Jan 2;24(1):6. (PMID: 38166801)
      BMJ Open Sport Exerc Med. 2020 Mar 16;6(1):e000658. (PMID: 32206341)
      J Obstet Gynaecol Can. 2018 Nov;40(11):1528-1537. (PMID: 30297272)
      Hypertension. 2019 Nov;74(5):1124-1135. (PMID: 31522621)
      Acta Obstet Gynecol Scand. 2020 Feb;99(2):153-166. (PMID: 31376293)
      Public Health Nutr. 2018 Oct 15;:1-15. (PMID: 30319090)
      Circulation. 2023 Mar 28;147(13):1014-1025. (PMID: 36883452)
      J Exp Med. 2014 Jan 13;211(1):165-79. (PMID: 24395887)
      Reprod Toxicol. 2011 Apr;31(3):363-73. (PMID: 21256208)
      J Pregnancy. 2011;2011:375653. (PMID: 21547089)
      Arch Gynecol Obstet. 2017 May;295(5):1061-1077. (PMID: 28285426)
      Am J Obstet Gynecol. 2022 Feb;226(2S):S1048-S1058. (PMID: 33002498)
      BJOG. 2024 Jan;131(1):46-62. (PMID: 36209504)
      Ultrasound Obstet Gynecol. 2017 Jun;49(6):756-760. (PMID: 28295782)
      BJOG. 2023 Nov;130 Suppl 3:8-15. (PMID: 37530495)
      Am J Obstet Gynecol. 2015 May;212(5):647.e1-11. (PMID: 25731694)
      BJOG. 2005 Jul;112(7):915-20. (PMID: 15957992)
      Br J Sports Med. 2012 Mar;46(4):279-83. (PMID: 21393257)
      Am J Obstet Gynecol. 2013 Apr;208(4):287.e1-287.e15. (PMID: 23333542)
      J Glob Health. 2022 Feb 19;12:04011. (PMID: 35198148)
      Eur Heart J. 2022 Sep 14;43(35):3352-3361. (PMID: 34643681)
      Thorax. 2010 Mar;65(3):235-40. (PMID: 20335293)
      Ultrasound Obstet Gynecol. 2018 Aug;52(2):186-195. (PMID: 29896812)
      Cardiology. 2020;145(10):633-647. (PMID: 32841945)
      Ultrasound Obstet Gynecol. 2017 Jan;49(1):73-77. (PMID: 27619203)
      Circulation. 2024 Jun 26;:. (PMID: 38923439)
      JAMA. 2021 Dec 7;326(21):2150-2160. (PMID: 34874420)
      N Engl J Med. 2017 Aug 17;377(7):613-622. (PMID: 28657417)
      Matern Child Health J. 2016 Jun;20(6):1193-202. (PMID: 26910608)
      Pregnancy Hypertens. 2022 Mar;27:42-50. (PMID: 34915395)
      Best Pract Res Clin Obstet Gynaecol. 2011 Jun;25(3):313-27. (PMID: 21388889)
      Int J Environ Res Public Health. 2020 Aug 24;17(17):. (PMID: 32847106)
      EBioMedicine. 2020 Apr;54:102710. (PMID: 32283530)
      Am Fam Physician. 2021 Jun 15;103(12):763-765. (PMID: 34128614)
      Aust N Z J Obstet Gynaecol. 2013 Dec;53(6):532-9. (PMID: 23919594)
      Lancet Glob Health. 2019 Jan;7(1):e37-e46. (PMID: 30389451)
      Reproduction. 2018 Oct 16;156(5):R155-R167. (PMID: 30325182)
      J Pathol Transl Med. 2015 Nov;49(6):462-71. (PMID: 26530045)
      Biol Reprod. 2010 Sep;83(3):325-31. (PMID: 20445129)
      Am J Obstet Gynecol. 2014 Jan;210(1):3-11. (PMID: 24359866)
      Alzheimers Dement (Amst). 2023 May 21;15(2):e12443. (PMID: 37223334)
      JAMA. 2021 Sep 28;326(12):1186-1191. (PMID: 34581729)
      BMC Pregnancy Childbirth. 2009 May 07;9 Suppl 1:S7. (PMID: 19426470)
      BJOG. 2022 Oct;129(11):1870-1877. (PMID: 35303394)
      Best Pract Res Clin Obstet Gynaecol. 2023 Dec;91:102407. (PMID: 37738759)
      J Clin Med. 2024 Mar 20;13(6):. (PMID: 38541997)
      Circulation. 2024 Feb 13;149(7):e330-e346. (PMID: 38346104)
      Nat Rev Dis Primers. 2023 Feb 16;9(1):8. (PMID: 36797292)
      Am J Obstet Gynecol. 2018 Mar;218(3):287-293.e1. (PMID: 29138036)
      Ultrasound Obstet Gynecol. 2018 Jun;51(6):743-750. (PMID: 29536574)
      BMJ. 2013 Jan 24;346:f108. (PMID: 23349424)
      J Matern Fetal Neonatal Med. 2009 Mar;22(3):183-90. (PMID: 19089779)
      Am J Obstet Gynecol. 2019 Nov;221(5):437-456. (PMID: 31163132)
      Int J Gynaecol Obstet. 2023 Jan;160(1):150-160. (PMID: 35695395)
      Am J Obstet Gynecol MFM. 2020 Nov;2(4):100229. (PMID: 32995736)
      BMJ. 2016 Apr 19;353:i1753. (PMID: 27094586)
      BJOG. 2024 Feb;131(3):334-342. (PMID: 37555464)
      Pregnancy Hypertens. 2017 Oct;10:155-160. (PMID: 29153670)
      Placenta. 2019 Oct;86:11-14. (PMID: 31491692)
      Cell Rep. 2021 Oct 5;37(1):109787. (PMID: 34610313)
      J Anat. 2024 Jun;244(6):1054-1066. (PMID: 38288680)
      Lancet. 2016 Oct 8;388(10053):1775-1812. (PMID: 27733286)
      Fertil Steril. 2019 Mar;111(3):489-496.e5. (PMID: 30709546)
      Hypertension. 2016 Mar;67(3):630-9. (PMID: 26781277)
      J Matern Fetal Neonatal Med. 2018 Sep;31(17):2276-2283. (PMID: 28612629)
      Br J Nutr. 2023 Sep 28;130(6):1065-1076. (PMID: 36484095)
      BMC Med. 2023 Dec 13;21(1):494. (PMID: 38093369)
      JAMA. 2011 Dec 14;306(22):2469-79. (PMID: 22166606)
      Am J Obstet Gynecol. 2012 Sep;207(3):179.e1-6. (PMID: 22939718)
      BJOG. 2021 Jan;128(2):238-250. (PMID: 32931648)
      Proc Biol Sci. 2023 Apr 26;290(1997):20230191. (PMID: 37072047)
      FASEB J. 2019 Nov;33(11):11682-11695. (PMID: 31356122)
      Ultrasound Obstet Gynecol. 2019 Feb;53(2):239-244. (PMID: 29700870)
      Int J Gynaecol Obstet. 2019 May;145 Suppl 1:1-33. (PMID: 31111484)
      Am J Obstet Gynecol. 2002 Nov;187(5):1137-42. (PMID: 12439491)
      Acta Obstet Gynecol Scand. 2024 Jun;103(6):1112-1119. (PMID: 38483020)
      N Engl J Med. 2016 Jan 7;374(1):13-22. (PMID: 26735990)
      Int J Mol Sci. 2020 Feb 19;21(4):. (PMID: 32093005)
      Hypertension. 2012 Mar;59(3):740-6. (PMID: 22311907)
      Nutrients. 2021 Apr 07;13(4):. (PMID: 33916963)
      Ultrasound Obstet Gynecol. 2015 Sep;46(3):299-305. (PMID: 25412757)
      PLoS Med. 2019 Jul 23;16(7):e1002857. (PMID: 31335871)
      Hypertension. 2021 Jun;77(6):2057-2065. (PMID: 33840202)
      Am J Obstet Gynecol. 2022 Feb;226(2S):S1108-S1119. (PMID: 32835720)
      Am J Obstet Gynecol. 1999 Feb;180(2 Pt 1):499-506. (PMID: 9988826)
      Lancet. 2011 May 14;377(9778):1703-17. (PMID: 21496907)
      J Clin Endocrinol Metab. 2004 Nov;89(11):5592-6. (PMID: 15531516)
      Am J Obstet Gynecol. 2004 Nov;191(5):1837-8; author reply 1838-9. (PMID: 15547578)
      JAMA Netw Open. 2024 May 1;7(5):e2412870. (PMID: 38814647)
      Am J Obstet Gynecol. 2020 Jul;223(1):12-23.e7. (PMID: 31733203)
      Mol Endocrinol. 2011 Aug;25(8):1444-55. (PMID: 21680659)
      BMJ Med. 2023 Jun 27;2(1):e000262. (PMID: 37564829)
      AJOG Glob Rep. 2024 Jan 09;4(1):100302. (PMID: 38318268)
      Am J Obstet Gynecol. 2017 Dec;217(6):685.e1-685.e5. (PMID: 28888591)
      Ultrasound Obstet Gynecol. 2013 Oct;42(4):478-9. (PMID: 23658028)
      Am J Obstet Gynecol. 2022 Feb;226(2S):S1071-S1097.e2. (PMID: 32682859)
      Nutr Diabetes. 2023 Nov 16;13(1):22. (PMID: 37973902)
      Pregnancy Hypertens. 2020 Jul;21:38-42. (PMID: 32388017)
      Placenta. 2006 Sep-Oct;27(9-10):939-58. (PMID: 16490251)
      Pregnancy Hypertens. 2021 Dec;26:102-109. (PMID: 34739939)
      Biomedicines. 2022 Mar 19;10(3):. (PMID: 35327520)
      Prenat Diagn. 2020 Apr;40(5):519-527. (PMID: 31955436)
      Eur J Obstet Gynecol Reprod Biol. 2018 Jun;225:26-34. (PMID: 29631209)
      Am J Obstet Gynecol. 2011 Mar;204(3):193-201. (PMID: 21094932)
      Nutrients. 2022 Aug 08;14(15):. (PMID: 35956418)
      Fertil Steril. 2010 Nov;94(6):2222-7, 2227.e1-3. (PMID: 20236632)
      Front Physiol. 2021 Jun 28;12:640024. (PMID: 34262468)
      Pregnancy Hypertens. 2022 Mar;27:148-169. (PMID: 35066406)
      Biol Reprod. 2014 Jun;90(6):130. (PMID: 24829026)
      Clin Endocrinol (Oxf). 2019 Jun;90(6):814-821. (PMID: 30801750)
      BJOG. 2015 Jan;122(1):41-55. (PMID: 25236870)
      Hum Reprod. 2015 Dec;30(12):2829-37. (PMID: 26498178)
      Ultrasound Obstet Gynecol. 2024 Mar;63(3):321-330. (PMID: 37902789)
      Lancet Digit Health. 2024 Apr;6(4):e238-e250. (PMID: 38519152)
      Ultrasound Obstet Gynecol. 2019 Feb;53(2):245-250. (PMID: 29917286)
      Placenta. 2016 Jun;42:1-8. (PMID: 27238707)
      J Clin Med. 2019 Nov 15;8(11):. (PMID: 31731659)
      Nat Rev Endocrinol. 2020 Sep;16(9):479-494. (PMID: 32601352)
      Int J Womens Health. 2023 Feb 13;15:255-271. (PMID: 36816456)
      Am J Obstet Gynecol. 2022 Jul;227(1):77.e1-77.e30. (PMID: 35114187)
      JAMA. 2023 Feb 21;329(7):542-550. (PMID: 36809321)
      Cureus. 2023 Mar 24;15(3):e36615. (PMID: 37155446)
      Adv Nutr. 2019 Jul 1;10(4):685-695. (PMID: 31041446)
      J Zhejiang Univ Sci B. 2016 Sep;17(9):649-56. (PMID: 27604857)
      Epidemiol Rev. 2010;32:5-25. (PMID: 20237078)
      JAMA. 2023 Feb 21;329(7):539-541. (PMID: 36809333)
      Front Endocrinol (Lausanne). 2023 Apr 05;14:1149284. (PMID: 37091849)
      BMC Sports Sci Med Rehabil. 2022 Jul 16;14(1):133. (PMID: 35842718)
      Lancet. 2018 May 5;391(10132):1830-1841. (PMID: 29673873)
      J Perinatol. 2020 Jan;40(1):10-24. (PMID: 31616048)
      Front Immunol. 2018 Nov 13;9:2597. (PMID: 30483261)
      Iran J Public Health. 2020 Oct;49(10):2018-2019. (PMID: 33346214)
      Am J Obstet Gynecol. 2023 Sep;229(3):222-247. (PMID: 36990308)
      BJOG. 2014 Apr;121(5):575-81. (PMID: 24418062)
      Hypertension. 2021 Feb;77(2):461-471. (PMID: 33280406)
      Commun Biol. 2021 May 14;4(1):572. (PMID: 33990675)
      J Matern Fetal Neonatal Med. 2007 Jul;20(7):495-507. (PMID: 17674262)
      Lancet. 2008 Jan 5;371(9606):75-84. (PMID: 18177778)
      J Clin Med. 2023 Aug 27;12(17):. (PMID: 37685649)
      Am J Obstet Gynecol. 2017 Mar;216(3):287.e1-287.e16. (PMID: 28034657)
      Hypertension. 2020 Apr;75(4):1125-1132. (PMID: 32114852)
      Cochrane Database Syst Rev. 2018 Nov 15;11:CD003402. (PMID: 30480773)
      Pregnancy Hypertens. 2019 Jul;17:28-35. (PMID: 31487652)
      Placenta. 2020 Dec;102:21-26. (PMID: 33218574)
      Fetal Diagn Ther. 2011;29(2):148-54. (PMID: 21079385)
      Am J Obstet Gynecol. 2016 Jan;214(1):103.e1-103.e12. (PMID: 26297382)
    • Contributed Indexing:
      Keywords: angiogenic ratio; aspirin; exercise; fetal growth restriction; lifestyle; multivariate screening; nutrition; pre-eclampsia; preterm labor; stillbirth
    • Publication Date:
      Date Created: 20240810 Latest Revision: 20240812
    • Publication Date:
      20240813
    • Accession Number:
      PMC11313446
    • Accession Number:
      10.3390/jcm13154344
    • Accession Number:
      39124610