Naturally acquired antibodies against 4 Streptococcus pneumoniae serotypes in Pakistani adults with type 2 diabetes mellitus.

Publisher: Public Library of Science Country of Publication: United States NLM ID: 101285081 Publication Model: eCollection Cited Medium: Internet ISSN: 1932-6203 (Electronic) Linking ISSN: 19326203 NLM ISO Abbreviation: PLoS One Subsets: MEDLINE

Original Publication: San Francisco, CA : Public Library of Science

Streptococcus pneumoniae*/immunology ; Diabetes Mellitus, Type 2*/immunology ; Diabetes Mellitus, Type 2*/microbiology ; Diabetes Mellitus, Type 2*/blood ; Antibodies, Bacterial*/blood ; Antibodies, Bacterial*/immunology ; Immunoglobulin G*/blood ; Immunoglobulin G*/immunology ; Serogroup* ; Pneumococcal Infections*/immunology ; Pneumococcal Infections*/microbiology; Humans ; Male ; Female ; Adult ; Middle Aged ; Pakistan/epidemiology ; Aged

Immune response elicited during pneumococcal carriage has been shown to protect against subsequent colonization and infection by Streptococcus pneumoniae. The study was designed to measure the baseline serotype-specific anti-capsular IgG concentration and opsonic titers elicited in response to asymptomatic carriage in adults with and without type 2-diabetes. Level of IgG to capsular polysaccharide was measured in a total of 176 samples (124 with type 2 diabetes and 52 without type 2 diabetes) against serotype 1, 19F, 9V, and 18C. From within 176 samples, a nested cohort of 39 samples was selected for measuring the functional capacity of antibodies by measuring opsonic titer to serotypes 19F, 9V, and 18C. Next, we measured levels of IgG to PspA in 90 samples from individuals with and without diabetes (22 non-diabetes and 68 diabetes). Our results demonstrated comparable IgG titers against all serotypes between those with and without type 2-diabetes. Overall, we observed higher opsonic titers in those without diabetes as compared to individuals with diabetes for serotypes 19F and 9V. The opsonic titers for 19F and 9V significantly negatively correlated with HbA1c. For 19F, 41.66% (n = 10) showed opsonic titers ≥ 1:8 in the diabetes group as compared to 66.66% (n = 10) in the non-diabetes group. The percentage was 29.6% (n = 7) vs 66.66% (n = 10) for 9V and 70.83% (n = 17) vs 80% (n = 12) for 18C in diabetes and non-diabetes groups respectively. A comparable anti-PspA IgG (p = 0.409) was observed in those with and without diabetes, indicating that response to protein antigen is likely to remain intact in those with diabetes. In conclusion, we demonstrated comparable IgG titers to both capsular polysaccharide and protein antigens in those with and without diabetes, however, the protective capacity of antibodies differed between the two groups.
Competing Interests: The authors have declared that no competing interests exist.
(Copyright: © 2024 Ahmad et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.)

Glycobiology. 2020 Mar 20;30(4):254-267. (PMID: 31616919)
Vaccine. 2014 Feb 12;32(8):979-83. (PMID: 24394442)
Diabetologia. 1986 Dec;29(12):850-4. (PMID: 3569690)
Microbes Infect. 2015 Mar;17(3):195-204. (PMID: 25528597)
APMIS. 2015 Feb;123(2):146-51. (PMID: 25351463)
Vaccine. 2013 Aug 2;31(35):3603-10. (PMID: 23711934)
J Infect Dis. 2000 Oct;182(4):1146-52. (PMID: 10979911)
Clin Microbiol Infect. 2013 Dec;19(12):E551-8. (PMID: 24255996)
Diabetes Care. 2004 May;27(5):1143-7. (PMID: 15111535)
J Immunol. 2004 Dec 15;173(12):7506-12. (PMID: 15585877)
Infect Immun. 1983 May;40(2):548-52. (PMID: 6840851)
Vaccine. 2020 Apr 9;38(17):3339-3350. (PMID: 32178906)
J Infect Dis. 1996 Feb;173(2):387-93. (PMID: 8568300)
Lancet Infect Dis. 2004 Mar;4(3):144-54. (PMID: 14998500)
Front Aging. 2021 Jul 23;2:715981. (PMID: 35822013)
J Infect Dis. 2003 Aug 1;188(3):339-48. (PMID: 12870114)
JAMA. 1985 Dec 13;254(22):3187-9. (PMID: 2933532)
J Infect Chemother. 2013 Jun;19(3):412-25. (PMID: 23657429)
Infect Immun. 2004 Jan;72(1):114-22. (PMID: 14688088)
Vaccine. 2023 Jul 12;41(31):4447-4452. (PMID: 37173269)
JPEN J Parenter Enteral Nutr. 1991 Jan-Feb;15(1):60-4. (PMID: 2008035)
Front Immunol. 2019 Mar 01;10:358. (PMID: 30881363)
Infect Immun. 2010 Feb;78(2):704-15. (PMID: 19948837)
mBio. 2020 May 19;11(3):. (PMID: 32430472)
ORL J Otorhinolaryngol Relat Spec. 1999 Jul-Aug;61(4):206-11. (PMID: 10450055)
Diabetes. 1981 Feb;30(2):119-21. (PMID: 7202857)
J Infect Dis. 2003 Jul 1;188(1):81-9. (PMID: 12825175)
Vaccine. 2007 Mar 22;25(13):2445-50. (PMID: 17052816)
Microb Drug Resist. 1997 Winter;3(4):401-8. (PMID: 9442494)
Trans R Soc Trop Med Hyg. 2015 Jan;109(1):9-15. (PMID: 25573105)
Aging Dis. 2012 Feb;3(1):51-67. (PMID: 22500271)
Clin Vaccine Immunol. 2008 Sep;15(9):1391-7. (PMID: 18596205)
Clin Vaccine Immunol. 2012 Sep;19(9):1360-9. (PMID: 22761295)
Transpl Int. 2017 Jul;30(7):689-694. (PMID: 28346714)
Clin Infect Dis. 2005 Aug 1;41(3):281-8. (PMID: 16007521)
Clin Microbiol Infect. 2007 Apr;13(4):369-76. (PMID: 17359320)
Clin Vaccine Immunol. 2016 Apr 04;23(4):379-85. (PMID: 26912783)
Int J Obes Relat Metab Disord. 2001 Oct;25(10):1407-15. (PMID: 11673759)
Diabetes Care. 2008 Aug;31(8):1541-5. (PMID: 18487479)
J Allergy Clin Immunol. 2009 Jan;123(1):195-200. (PMID: 18951616)
Nat Immunol. 2023 Aug;24(8):1244-1255. (PMID: 37414906)
J Infect Dis. 2003 May 15;187(10):1639-45. (PMID: 12721944)
MMWR Morb Mortal Wkly Rep. 2018 Feb 09;67(5):156-157. (PMID: 29420458)
Vaccine. 2024 Apr 2;42(9):2448-2454. (PMID: 38458872)
Clin Vaccine Immunol. 2007 Nov;14(11):1442-50. (PMID: 17881503)
Obesity (Silver Spring). 2016 Mar;24(3):615-25. (PMID: 26857091)
Microb Genom. 2024 Jan;10(1):. (PMID: 38270581)
BMC Microbiol. 2009 May 06;9:80. (PMID: 19419534)
Nat Rev Microbiol. 2018 Jun;16(6):355-367. (PMID: 29599457)
Infect Immun. 2011 Jan;79(1):314-20. (PMID: 21041499)
Am J Prev Med. 2018 May;54(5):630-636. (PMID: 29551328)
Blood. 2008 Jul 1;112(1):82-9. (PMID: 18316629)
J Infect Dis. 2005 Aug 1;192(3):387-93. (PMID: 15995951)
Nat Commun. 2020 Jun 1;11(1):2719. (PMID: 32483195)
Microb Pathog. 2018 Oct;123:115-119. (PMID: 29959043)
J Allergy Clin Immunol. 2012 Sep;130(3 Suppl):S1-24. (PMID: 22935624)
Glycobiology. 2012 Feb;22(2):221-34. (PMID: 21930650)
Transl Res. 2014 Jan;163(1):53-63. (PMID: 23927943)
Clin Kidney J. 2015 Jun;8(3):318-24. (PMID: 26034594)
Vaccine. 2020 Nov 3;38(47):7479-7484. (PMID: 33039208)
Vaccine. 2021 May 18;39(21):2850-2856. (PMID: 33896666)
Front Immunol. 2018 Jun 22;9:1366. (PMID: 29988379)
Diabetes Res Clin Pract. 2005 Jul;69(1):29-35. (PMID: 15955385)
J Infect Dis. 2002 Oct 15;186(8):1106-14. (PMID: 12355361)
Nat Rev Immunol. 2011 Feb;11(2):85-97. (PMID: 21252989)
J Am Soc Mass Spectrom. 2000 Feb;11(2):153-9. (PMID: 10689668)
Front Aging. 2023 Oct 11;4:1272336. (PMID: 37886013)
J Transl Med. 2012 Mar 05;10:35. (PMID: 22390383)
J Mol Med (Berl). 2010 Feb;88(2):135-42. (PMID: 20049411)
J Endocrinol. 2006 Feb;188(2):295-303. (PMID: 16461555)
Cell Physiol Biochem. 2016;38(3):1257-66. (PMID: 26982979)
Thorax. 2015 Oct;70(10):984-9. (PMID: 26219979)
Diabetes Res Clin Pract. 2022 Jan;183:109119. (PMID: 34879977)
J Diabetes Res. 2014;2014:762051. (PMID: 25610878)
Vaccine. 2004 Dec 21;23(6):762-8. (PMID: 15542200)
Medicine (Baltimore). 2016 Jun;95(26):e4064. (PMID: 27368047)
J Diabetes Res. 2017;2017:5052812. (PMID: 28491871)
CMAJ Open. 2021 Jan 25;9(1):E62-E70. (PMID: 33495386)
Infect Immun. 2012 Jun;80(6):2186-93. (PMID: 22451514)
Vaccine. 2017 Aug 3;35(34):4444-4449. (PMID: 28410813)
Exp Clin Endocrinol Diabetes. 2008 Mar;116(3):162-6. (PMID: 18213547)
Med Mal Infect. 2012 Aug;42(8):361-5. (PMID: 22819510)
Hum Vaccin Immunother. 2016;12(1):194-205. (PMID: 26539741)
J Allergy Clin Immunol. 1998 Aug;102(2):215-21. (PMID: 9723664)
J Exp Med. 2002 Feb 4;195(3):359-65. (PMID: 11828011)
Am J Med Sci. 2016 Feb;351(2):201-11. (PMID: 26897277)
J Immunol. 2016 Feb 15;196(4):1435-41. (PMID: 26851295)
FEMS Immunol Med Microbiol. 1999 Dec;26(3-4):259-65. (PMID: 10575137)
Infect Immun. 2003 Jan;71(1):75-85. (PMID: 12496151)
JAMA. 1993 Oct 20;270(15):1826-31. (PMID: 8411526)
Autoimmunity. 2006 Mar;39(2):137-41. (PMID: 16698670)
Infect Immun. 1999 Sep;67(9):4720-4. (PMID: 10456922)
J Infect Dis. 2012 May 15;205(10):1589-92. (PMID: 22448012)
Vaccines (Basel). 2023 Nov 29;11(12):. (PMID: 38140184)
Clin Vaccine Immunol. 2015 Feb;22(2):148-52. (PMID: 25520149)
Clin Vaccine Immunol. 2006 Feb;13(2):165-9. (PMID: 16467321)
J Infect Dis. 1997 Apr;175(4):839-46. (PMID: 9086139)
Gerontology. 2003 Jul-Aug;49(4):246-50. (PMID: 12792160)
Infect Immun. 2004 Sep;72(9):5031-40. (PMID: 15321996)
J Pharm Sci. 2015 Jun;104(6):1866-1884. (PMID: 25872915)
Obes Res. 2003 Apr;11(4):525-31. (PMID: 12690081)
Clin Exp Immunol. 1994 Nov;98(2):245-51. (PMID: 7955529)
Clin Chem. 1999 Feb;45(2):288-90. (PMID: 9931055)
Immun Ageing. 2023 May 2;20(1):18. (PMID: 37131271)
J Exp Med. 1984 Aug 1;160(2):386-97. (PMID: 6381634)

0 (Antibodies, Bacterial)
0 (Immunoglobulin G)

Date Created: 20240809 Date Completed: 20240809 Latest Revision: 20240811

20240812

PMC11315336

10.1371/journal.pone.0306921

39121085