IVF and obstetric outcomes among women of advanced maternal age (≥45 years) using donor eggs.

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  • Author(s): Chen TS;Chen TS; Kuo PL; Kuo PL; Kuo PL; Yu T; Yu T; Wu MH; Wu MH
  • Source:
    Reproductive biomedicine online [Reprod Biomed Online] 2024 Oct; Vol. 49 (4), pp. 104291. Date of Electronic Publication: 2024 May 24.
  • Publication Type:
    Journal Article
  • Language:
    English
  • Additional Information
    • Source:
      Publisher: Elsevier Country of Publication: Netherlands NLM ID: 101122473 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1472-6491 (Electronic) Linking ISSN: 14726483 NLM ISO Abbreviation: Reprod Biomed Online Subsets: MEDLINE
    • Publication Information:
      Publication: <2009->: Amsterdam : Elsevier
      Original Publication: Cambridge, UK : Reproductive Healthcare Ltd.
    • Subject Terms:
      Fertilization in Vitro*/statistics & numerical data ; Maternal Age* ; Oocyte Donation*/statistics & numerical data ; Pregnancy Outcome*/epidemiology; Humans ; Female ; Pregnancy ; Middle Aged ; Retrospective Studies ; Taiwan/epidemiology ; Pregnancy Rate ; Embryo Transfer/statistics & numerical data ; Embryo Transfer/methods ; Birth Rate
    • Abstract:
      Research Question: Does very advanced maternal age (VAMA; age ≥45 years) influence obstetric outcomes among women using donor oocytes in IVF?
      Design: This retrospective cohort study analysed data from a nationwide IVF registry in Taiwan, focusing on IVF cycles involving women aged 45 years and older using donated oocytes between 2007 and 2016. The study assessed cumulative live birth rates (CLBR) and secondary outcomes such as clinical pregnancy, miscarriage, live birth and twin pregnancy rates, alongside perinatal outcomes such as Caesarean section rates, pre-eclampsia, gestational diabetes and birthweight.
      Results: The study included 1226 embryo transfer cycles from 745 women, with a stable live birth rate of about 40% across the study period. The CLBR was slightly lower in women aged 50 years and older (54.2%) compared with those aged 45-46 years (58.0%), but these differences were not statistically significant (P = 0.647). Secondary outcomes and perinatal outcomes did not significantly differ across age groups. Regression analysis suggested a non-significant trend towards a decrease in live birth rate and birthweight with increasing maternal age. The study also found that single-embryo transfer (SET) minimized the risk of twin pregnancies without significantly affecting live birth rates.
      Conclusions: IVF with donor oocytes remains a viable option for women of VAMA, with consistent live birth rates across age groups. However, the study underscores the importance of elective SET to reduce the risk of twin pregnancies and associated adverse outcomes. Further research is needed to explore the impact of other factors such as paternal age and embryo development stage on IVF success in this population.
      (Copyright © 2024 Reproductive Healthcare Ltd. Published by Elsevier Ltd. All rights reserved.)
    • Contributed Indexing:
      Keywords: Advanced maternal age; IVF; Multiple pregnancy; Oocyte donation; Single embryo transfer
    • Publication Date:
      Date Created: 20240808 Date Completed: 20240913 Latest Revision: 20240924
    • Publication Date:
      20240924
    • Accession Number:
      10.1016/j.rbmo.2024.104291
    • Accession Number:
      39116639