Association between the systemic immune-inflammation index and obesity among adults: Insights from the NHANES 2017-2018.

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  • Author(s): Yu Y;Yu Y; Tan T; Tan T; Yang W; Yang W; Xu Z; Xu Z; Liu Y; Liu Y
  • Source:
    PloS one [PLoS One] 2024 Aug 08; Vol. 19 (8), pp. e0308288. Date of Electronic Publication: 2024 Aug 08 (Print Publication: 2024).
  • Publication Type:
    Journal Article
  • Language:
    English
  • Additional Information
    • Source:
      Publisher: Public Library of Science Country of Publication: United States NLM ID: 101285081 Publication Model: eCollection Cited Medium: Internet ISSN: 1932-6203 (Electronic) Linking ISSN: 19326203 NLM ISO Abbreviation: PLoS One Subsets: MEDLINE
    • Publication Information:
      Original Publication: San Francisco, CA : Public Library of Science
    • Subject Terms:
      Obesity*/immunology ; Obesity*/epidemiology ; Inflammation*/immunology ; Inflammation*/blood ; Nutrition Surveys* ; Body Mass Index*; Humans ; Male ; Middle Aged ; Female ; Adult ; United States/epidemiology ; Neutrophils/immunology ; Aged ; Young Adult ; Platelet Count
    • Abstract:
      Background: Inflammation is an important causative factor of obesity. This study aimed to explore the possible association between the systemic immune-inflammatory index, a novel indicator of inflammation, and obesity.
      Methods: Data were collected from 4395 participants of the National Health and Nutrition Examination Survey 2017-2018 aged ≥ 20 years. The systemic immune-inflammatory index was calculated by multiplying the platelet count by the neutrophil-to-lymphocyte ratio. Obesity was defined as a body mass index ≥ 30 kg/m2.
      Results: A significant positive correlation was observed between the systemic immune-inflammatory index and body mass index following multivariate linear regression analysis (β = 1.75; 95% confidence interval = 1.16-2.33), which was greatest in adults aged < 60 years without hypertension and diabetes. Smoothed curve fitting and threshold effect analysis were used to characterize the nonlinear association between the systemic immune-inflammatory index and body mass index, and the inflection point was found to be 729.3.
      Conclusions: The systemic immune-inflammatory index is positively associated with body mass index among adults in the United States and has the potential to enhance efforts to prevent adult obesity.
      Competing Interests: The authors have declared that no competing interests exist.
      (Copyright: © 2024 Yu et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.)
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    • Publication Date:
      Date Created: 20240808 Date Completed: 20240808 Latest Revision: 20240810
    • Publication Date:
      20240812
    • Accession Number:
      PMC11309425
    • Accession Number:
      10.1371/journal.pone.0308288
    • Accession Number:
      39116149