Hepatic cell junctions: Pulling a double-duty.

Publisher: Wiley-Blackwell Country of Publication: United States NLM ID: 101160857 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1478-3231 (Electronic) Linking ISSN: 14783223 NLM ISO Abbreviation: Liver Int Subsets: MEDLINE

Publication: Malden, MA : Wiley-Blackwell
Original Publication: Oxford, UK : Blackwell Munksgaard, c2003-

Intercellular Junctions*/physiology ; Liver* ; Cell Communication*/physiology; Humans ; Liver Diseases/physiopathology ; Liver Diseases/pathology ; Animals ; Hepatocytes/physiology ; Cell Adhesion

Cell junctions, including anchoring, occluding and communicating junctions, play an indispensable role in the structural and functional organization of multicellular tissues, including in liver. Specifically, hepatic cell junctions mediate intercellular adhesion and communication between liver cells. The establishment of the hepatic cell junction network is a prerequisite for normal liver functioning. Hepatic cell junctions indeed support liver-specific features and control essential aspects of the hepatic life cycle. This review paper summarizes the role of cell junctions and their components in relation to liver physiology, thereby also discussing their involvement in hepatic dysfunctionality, including liver disease and toxicity.
(© 2024 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.)

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858014 European Horizon 2020 Future and Emerging Technologies program; G012318N Research Foundation Flanders-Belgium; G020018N Research Foundation Flanders-Belgium; G0F7219N Research Foundation Flanders-Belgium; the Methusalem program of the Flemish Government; the University Hospital of the Vrije Universiteit Brussel-Belgium (Scientific Fund Willy Gepts)

Keywords: adherens junctions; desmosomes; gap junctions; liver; tight junctions

Date Created: 20240808 Date Completed: 20241023 Latest Revision: 20241023

20241023

10.1111/liv.16045

39115254