Human Electroretinography Shows Little Polarity Specificity Following Full-Field Ramp Adaptation.

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  • Additional Information
    • Source:
      Publisher: Association For Research In Vision And Ophthalmology (Arvo) Country of Publication: United States NLM ID: 7703701 Publication Model: Print Cited Medium: Internet ISSN: 1552-5783 (Electronic) Linking ISSN: 01460404 NLM ISO Abbreviation: Invest Ophthalmol Vis Sci Subsets: MEDLINE
    • Publication Information:
      Publication: Brookline Ma : Association For Research In Vision And Ophthalmology (Arvo)
      Original Publication: St. Louis, Mosby.
    • Subject Terms:
      Electroretinography*/methods ; Adaptation, Ocular*/physiology ; Photic Stimulation*; Humans ; Adult ; Male ; Female ; Young Adult ; Retina/physiology ; Psychophysics
    • Abstract:
      Purpose: The ramp aftereffect, a visual phenomenon in which perception of light changes dynamically after exposure to sawtooth-modulated light, was first described in 1967. Despite decades of psychophysical research, location and mechanisms of its generation remain unknown. In this study, we investigated a potential retinal contribution to effect formation with specific emphasis on on-/off-pathway involvement.
      Methods: A 100 ms flash electroretinogram (ERG) was employed to probe the adaptive state of retinal neurons after presentation of stimuli that were homogenous in space but modulated in time following a sawtooth pattern (upward or downward ramps at 2 Hz). Additionally, a psychophysical nulling experiment was performed.
      Results: Psychophysics data confirmed previous findings that the ramp aftereffect opposes the adapting stimuli in ramp direction and is stronger after upward ramps. The ERG study revealed significant changes of activity in every response component in the low-frequency range (a-wave, b-wave, on-PhNR, d-wave and off-PhNR) and high-frequency range (oscillatory potentials) in amplitudes, peak times, or both. The changes are neither specific to the on- or off-response nor antagonistic between ramp directions. With downward ramp adaptation, effects were stronger. Neither amplitudes nor peak times were correlated with perception strength. Amplitudes and peak times were uncorrelated, and the effect diminished over time, ceasing almost completely with three seconds.
      Conclusions: Despite abundant effects on retinal responses, the pattern of adaptational effects was not specific to the sawtooth nature of adaptation. Although not ruling out retinal contributions the present findings favor post-retinal mechanisms as the primary locus of the ramp aftereffect.
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    • Publication Date:
      Date Created: 20240806 Date Completed: 20240806 Latest Revision: 20240810
    • Publication Date:
      20240812
    • Accession Number:
      PMC11309038
    • Accession Number:
      10.1167/iovs.65.10.11
    • Accession Number:
      39106057