Recent developments in the design of functional derivatives of edaravone and exploration of their antioxidant activities.

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Publisher: ESCOM Science Publishers Country of Publication: Netherlands NLM ID: 9516534 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1573-501X (Electronic) Linking ISSN: 13811991 NLM ISO Abbreviation: Mol Divers Subsets: MEDLINE

Original Publication: Leiden, The Netherlands : ESCOM Science Publishers, c1995-

Edaravone, a pyrazalone derivative, is an antioxidant and free radical scavenger used to treat oxidative stress-related diseases. It is a proven drug to mitigate conditions prevailing to oxidative stress by inhibiting lipid peroxidation, reducing inflammation, and thereby preventing endothelial cell death. In recent years, considerable interest has been given by researchers in the derivatization of edaravone by adding varieties of substituents of versatile steric and functional properties to improve its antioxidant and pharmacological activity. This review accounts all the important methods developed for the derivatization of edaravone and the impacts of the structural modifications on the antioxidant activity of the motif.
(© 2024. The Author(s), under exclusive licence to Springer Nature Switzerland AG.)

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Keywords: Antioxidants; Derivatization; Edaravone; Oxidative stress; Reactive oxygen species (ROS)

Date Created: 20240805 Latest Revision: 20240805

20240805

10.1007/s11030-024-10940-7

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