Protective effects of alpha-lipoic acid and alagebrium chloride against testicular dysfunction induced by varicocele and advanced glycation end (AGE) - Rich diet in a rat mode.

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  • Additional Information
    • Source:
      Publisher: Churchill Livingstone Country of Publication: Scotland NLM ID: 0214745 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1532-3072 (Electronic) Linking ISSN: 00408166 NLM ISO Abbreviation: Tissue Cell Subsets: MEDLINE
    • Publication Information:
      Publication: Edinburgh : Churchill Livingstone
      Original Publication: Edinburgh, Oliver & Boyd.
    • Subject Terms:
      Thioctic Acid*/pharmacology ; Glycation End Products, Advanced*/metabolism ; Testis*/metabolism ; Testis*/drug effects ; Testis*/pathology ; Varicocele*/metabolism; Male ; Animals ; Rats ; Receptor for Advanced Glycation End Products/metabolism ; Spermatozoa/drug effects ; Spermatozoa/metabolism ; Oxidative Stress/drug effects ; Protective Agents/pharmacology ; Antioxidants/pharmacology ; Diet ; Tumor Necrosis Factor-alpha/metabolism ; Disease Models, Animal ; Rats, Sprague-Dawley ; Thiazoles
    • Abstract:
      Heat stress from varicocele can heighten oxidative stress in the testes, impacting sperm function and male fertility. Antioxidant therapy is explored as a remedy for varicocele, while dietary factors like processed foods, sugar, and saturated fats correlate with male infertility. Advanced glycation end products (AGEs), generated through glycation processes, can provoke oxidative stress, inflammation, and adverse health consequences. Alpha-lipoic acid (ALA), a versatile antioxidant, may alleviate oxidative stress and counteract the impact of AGEs, potentially by enhancing glucose reabsorption. Alagebrium chloride (ALT711), an anti-AGE compound, exhibits promise in cardiovascular disease by disrupting AGE cross-links. This study investigates the effects of ALA and ALT-711 on testicular function in varicocele and AGEs animal models. Both AGE and varicocele were found to alter the natural trends, leading to abnormal patterns in sperm parameters, testicular functional tests, as well as the expression of CML, RAGE, and TNF-α proteins. However, the administration of ALA or ALT711 helped mitigate these effects. While ALA demonstrated a slightly greater overall benefit compared to ALT, the difference was not statistically significant.
      Competing Interests: Declaration of Competing Interest The authors report no financial or commercial conflicts of interest.
      (Copyright © 2024 Elsevier Ltd. All rights reserved.)
    • Contributed Indexing:
      Keywords: Advanced glycation end products; Alagebrium chloride; Alpha-lipoic acid; Sperm parameters; Testicular function; Varicocele
    • Accession Number:
      73Y7P0K73Y (Thioctic Acid)
      0 (Glycation End Products, Advanced)
      DGH49JXB1F (alagebrium)
      0 (Receptor for Advanced Glycation End Products)
      0 (Protective Agents)
      0 (Antioxidants)
      0 (Tumor Necrosis Factor-alpha)
      0 (Thiazoles)
    • Publication Date:
      Date Created: 20240804 Date Completed: 20240902 Latest Revision: 20240902
    • Publication Date:
      20240902
    • Accession Number:
      10.1016/j.tice.2024.102509
    • Accession Number:
      39098258