Posthemithyroidectomy hypothyroidism. Prevalence and predictive markers. Comparison between patients with euthyroid and hyperthyroid nodular goitre.

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  • Additional Information
    • Source:
      Publisher: Country of Publication: Spain NLM ID: 101717565 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2530-0180 (Electronic) Linking ISSN: 25300180 NLM ISO Abbreviation: Endocrinol Diabetes Nutr (Engl Ed) Subsets: MEDLINE
    • Publication Information:
      Original Publication: [Barcelona] : [Elsevier España], 2017-
    • Subject Terms:
      Hypothyroidism*/epidemiology ; Hypothyroidism*/blood ; Hypothyroidism*/etiology ; Thyroidectomy* ; Goiter, Nodular*/surgery ; Goiter, Nodular*/epidemiology ; Hyperthyroidism*/epidemiology ; Hyperthyroidism*/blood ; Hyperthyroidism*/surgery; Humans ; Cross-Sectional Studies ; Female ; Male ; Retrospective Studies ; Middle Aged ; Prevalence ; Adult ; Postoperative Complications/epidemiology ; Postoperative Complications/etiology ; Postoperative Complications/blood ; Aged ; Biomarkers/blood ; Thyrotropin/blood
    • Abstract:
      Background and Objective: Posthemithyroidectomy hypothyroidism (PHH) is a relatively common complication (22%-30%) for which we have no published information from our country. The objective of the study is to determine the prevalence of PHH and evaluate its predictive markers by comparing patients who had euthyroidism with those who had hyperthyroidism before hemithyroidectomy.
      Patients and Method: Retrospective observational cross-sectional study on 106 patients, 88 euthyroid before hemithyroidectomy and 18 hyperthyroid.
      Results: Prevalence of PHH in euthyroid patients 42% (89.2% subclinical hypothyroidism; 10.8% manifest hypothyroidism) and in hyperthyroid patients 50% (77.8% subclinical hypothyroidism; 22.2% manifest hypothyroidism). Predictive markers in euthyroid patients: preoperative thyrotropin ≥ 2.2 mIU/L (OR: 4.278, 95% CI: 1.689-10.833; sensitivity: 54.1%, 95% CI: 38%-70.1%; specificity: 78.4%, 95% CI: 67.1%-89.7%), age ≥50 years (OR: 3.509, 95% CI: 1.438-8.563; sensitivity: 64.9%, 95% CI: 49.5%-80.3%; specificity: 64.7%, 95% CI: 51.6%-77.8%) and percentage of remainder lobe ≤ 19.6% (OR: 1.024, 95%: 1.002-1.046; sensitivity: 70.2%, 95% CI: 55.5%-84.9%; specificity: 48.6%, 95% CI: 34.9%-62.3%). Predictive marker in hyperthyroid patients: weight >70 kg (OR: 28, 95% CI: 2.067-379.247; sensitivity: 88.9%, 95% CI: 68.4%-100%; specificity: 88.9%, 95% CI: 68.4%-100%).
      Conclusions: This is the first study in our country that demonstrates a prevalence of PHH above the average in euthyroid patients, which is slightly higher and more intense in hyperthyroid patients, and that recognizes the classic predictive markers in euthyroid patients but highlights a novel predictive marker marker in hyperthyroid patients, useful to assess a different risk of PHH when indicating hemithyroidectomy and to establish closer control of postoperative hormonal evolution.
      (Copyright © 2024 SEEN and SED. Published by Elsevier España, S.L.U. All rights reserved.)
    • Contributed Indexing:
      Keywords: Hemithyroidectomy; Hemitiroidectomía; Hipotiroidismo; Hipotiroidismo postoperatorio; Hypothyroidism; Postoperative hypothyroidism
    • Accession Number:
      0 (Biomarkers)
      9002-71-5 (Thyrotropin)
    • Publication Date:
      Date Created: 20240803 Date Completed: 20240825 Latest Revision: 20240827
    • Publication Date:
      20240827
    • Accession Number:
      10.1016/j.endien.2024.05.003
    • Accession Number:
      39097481