Long-Term Outcome After Canaloplasty and Phacocanaloplasty in Primary Open Angle Glaucoma.

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  • Additional Information
    • Source:
      Publisher: Wolters Kluwer Health, Inc Country of Publication: United States NLM ID: 9300903 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1536-481X (Electronic) Linking ISSN: 10570829 NLM ISO Abbreviation: J Glaucoma Subsets: MEDLINE
    • Publication Information:
      Publication: <2015- > : Philadelphia, PA : Wolters Kluwer Health, Inc.
      Original Publication: New York, N.Y. : Raven Press, c1992-
    • Subject Terms:
      Glaucoma, Open-Angle*/surgery ; Glaucoma, Open-Angle*/physiopathology ; Intraocular Pressure*/physiology ; Phacoemulsification* ; Filtering Surgery*/methods ; Tonometry, Ocular*; Humans ; Female ; Male ; Retrospective Studies ; Aged ; Follow-Up Studies ; Middle Aged ; Treatment Outcome ; Visual Acuity/physiology ; Antihypertensive Agents/therapeutic use ; Aged, 80 and over ; Lens Implantation, Intraocular
    • Abstract:
      Prcis: Canaloplasty and phacocanaloplasty achieve a statistically significant intraocular pressure (IOP)-reduction for up to 11 years and decrease the long-term need for glaucoma medications. Both procedures have a low long-term complication rate.
      Purpose: To evaluate the long-term outcome of canaloplasty with and without cataract surgery in primary open angle glaucoma (POAG) patients.
      Patients and Methods: In all, 48 eyes of 34 patients with POAG who successfully received canaloplasty alone (group A, n=28) or with phacoemulsification (group B, n=20) were retrospectively analyzed. Demographic data, IOP, and IOP-lowering medication were recorded presurgery and postsurgery with a follow-up of up to 14 years.
      Results: The mean follow-up time in group A was 91.4±45.0 months. Mean IOP dropped from 22.0±3.8 mm Hg at baseline to 14.0±3.3, 14.3±3.1, 14.4±3.8, and 16.5±1.2 mm Hg at 1, 4, 7, and 10 years, respectively. IOP-lowering medication count decreased from 1.5±1.0 at baseline to 0.1±0.4, 0.3±0.6, 0.6±0.9, and 0.9±1.1 at 1, 4, 7, and 10 years, respectively. The mean follow-up time in group B was 109.1±25.7 months. Mean IOP dropped from 24.5±6.0 at baseline to 13.8±2.9, 14.9±3.6, 15.3±2.9, and 14.8±2.0 mm Hg at 1, 4, 7, and 10 years, respectively. IOP-lowering medication count decreased from 2.2±1.2 before surgery to 0.0, 0.1±0.3, 0.1±0.2, and 0.5±0.9 at 1, 4, 7, and 10 years, respectively.
      Conclusion: Canaloplasty and phacocanaloplasty achieved a comparable decrease in IOP and glaucoma medication count with a low complication rate. Both procedures showed a high long-term success rate.
      Competing Interests: Disclosure: The authors declare no conflict of interest.
      (Copyright © 2024 Wolters Kluwer Health, Inc. All rights reserved.)
    • References:
      Flaxman SR, Bourne RRA, Resnikoff S, et al. Global causes of blindness and distance vision impairment 1990–2020: a systematic review and meta-analysis. Lancet Glob Health. 2017;5:e1221–e1234.
      Bull H, von Wolff K, Körber N, et al. Three-year canaloplasty outcomes for the treatment of open-angle glaucoma: European study results. Graefes Arch Clin Exp Ophthalmol. 2011;249:1537–1545.
      Tetz M, Koerber N, Shingleton BJ, et al. Phacoemulsification and intraocular lens implantation before, during, or after canaloplasty in eyes with open-angle glaucoma: 3-year results. J Glaucoma. 2015;24:187–194.
      Lewis RA, von Wolff K, Tetz M, et al. Canaloplasty: three-year results of circumferential viscodilation and tensioning of Schlemm canal using a microcatheter to treat open-angle glaucoma. J Cataract Refract Surg. 2011;37:682–690.
      Brusini P, Caramello G, Benedetti S, et al. Canaloplasty in Open-angle glaucoma: mid-term results from a multicenter study. J Glaucoma. 2016;25:403–407.
      Vastardis I, Fili S, Gatzioufas Z, et al. Ab externo canaloplasty results and efficacy: a retrospective cohort study with a 12-month follow-up. Eye Vis. 2019;6:9.
      Zhang B, Kang J, Chen X. A system review and meta-analysis of canaloplasty outcomes in glaucoma treatment in comparison with trabeculectomy. J Ophthalmol. 2017;2017:1–9.
      Stroup WW. Generalized Linear Mixed Models, CRC Press; 2016.
      Gałecki A, Burzykowski T. Linear Mixed-Effects Models Using R: A Step-by-Step Approach. New York: Springer; 2013.
      Bates D, Mächler M, Bolker B, et al. Fitting linear mixed-effects models using lme4. J Stat Softw. 2015;67:1–48.
      Kuznetsova A, Brockhoff PB, Christensen RHB. lmerTest Package: tests in linear mixed effects models. J Stat Softw. 2017;82:1–26.
      Grieshaber MC, Pienaar A, Olivier J, et al. Canaloplasty for primary open-angle glaucoma: long-term outcome. Br J Ophthalmol. 2010;94:1478–1482.
      Brusini P, Papa V. Canaloplasty in pigmentary glaucoma: long-term outcomes and proposal of a new hypothesis on its intraocular pressure lowering mechanism. J Clin Med. 2020;9:4024.
      Camp A, Wellik SR, Tzu JH, et al. Dry eye specific quality of life in veterans using glaucoma drops. Contact Lens Anterior Eye. 2015;38:220–225.
      Moelle MC, Cursiefen C, Rejdak R, et al. Time course of induced astigmatism after canaloplasty. J Glaucoma. 2014;23:e53–e59.
      Brüggemann A, Müller M. Trabekulektomie versus Kanaloplastik—eine Kosten- und Aufwandsanalyse. Klin Monatsblätter Für Augenheilkd. 2012;229:1118–1123.
      Matlach J, Sauer J, Körber N, et al. Quality of life following glaucoma surgery: canaloplasty versus trabeculectomy. Clin Ophthalmol. 2014;9:7–16.
    • Accession Number:
      0 (Antihypertensive Agents)
    • Publication Date:
      Date Created: 20240802 Date Completed: 20241104 Latest Revision: 20241104
    • Publication Date:
      20241104
    • Accession Number:
      10.1097/IJG.0000000000002473
    • Accession Number:
      39093018