Intraocular Pressure Response to Perceived Stress in Juvenile-Onset Open Angle Glaucoma.

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  • Additional Information
    • Source:
      Publisher: Wolters Kluwer Health, Inc Country of Publication: United States NLM ID: 9300903 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1536-481X (Electronic) Linking ISSN: 10570829 NLM ISO Abbreviation: J Glaucoma Subsets: MEDLINE
    • Publication Information:
      Publication: <2015- > : Philadelphia, PA : Wolters Kluwer Health, Inc.
      Original Publication: New York, N.Y. : Raven Press, c1992-
    • Subject Terms:
      Intraocular Pressure*/physiology ; Glaucoma, Open-Angle*/physiopathology ; Glaucoma, Open-Angle*/psychology ; Tonometry, Ocular* ; Stress, Psychological*; Humans ; Male ; Female ; Young Adult ; Adolescent ; Adult ; Antihypertensive Agents/therapeutic use
    • Abstract:
      Prcis: High perceived stress from academic pressure is associated with intraocular pressure (IOP) elevation and reduced fluctuation in juvenile-onset open angle glaucoma patients. Personalized stress assessment and relief strategies may serve as an adjunct therapy in glaucoma.
      Objective: To evaluate the effect of higher perceived stress, resulting from academic pressure, on IOP in juvenile-onset open angle glaucoma (JOAG) patients compared with healthy individuals.
      Methods: The study included 48 university students aged 18-27 years, comprising 24 JOAG patients on antiglaucoma eyedrops and 24 healthy controls. In an examiner-blind pretest-posttest design, participants' IOP was measured weekly using Goldmann tonometry during three follow-up visits at the beginning and end of the academic semester. Perceived Stress Scale (PSS) scores were also evaluated at these 2-time points to capture the contrast in perceived stress between periods of low and high academic pressure.
      Results: The baseline PSS score at the semester's start was lower in both groups (14.1±1.9 in glaucoma vs. 13.5±2.4 in control) and significantly increased by the end of the semester (29.2±2.1 vs. 28.5±1.3; P <0.001), indicating increased perceived stress. Concurrently, IOP rose from 22.01±5.87 to 25.08±5.84 mm Hg in the glaucoma group and from 11.36±2.03 to 13.65±2.11 mm Hg in the control group. Factorial analysis revealed a significant interaction between stress and JOAG ( F(1,94) =15.94, P =0.001), partial η 2 =0.08, with stress having a greater increase on IOP in the glaucoma group (+3.10 mm Hg) compared with the control group (+2.23 mm Hg) ( t(94) =4.457, P <0.001).
      Conclusions: Higher perceived stress significantly increases IOP, especially in JOAG patients, suggesting personalized stress management as a potential adjunct therapy for patients.
      Competing Interests: Disclosure: The authors declare no conflict of interest.
      (Copyright © 2024 Wolters Kluwer Health, Inc. All rights reserved.)
    • References:
      Nuzzi R, Dallorto L, Rolle T. Changes of visual pathway and brain connectivity in glaucoma: a systematic review. Front Neurosci. 2018;12:363.
      Allison K, Patel D, Alabi O. Epidemiology of glaucoma: the past, present, and predictions for the future. Cureus. 2020;12:e11686.
      Wagner IV, Stewart MW, Dorairaj SK. Updates on the diagnosis and management of glaucoma. Mayo Clin Proc Innov Qual Outcomes. 2022;6:618–635.
      Evangelho K, Mogilevskaya M, Losada-Barragan M, et al. Pathophysiology of primary open-angle glaucoma from a neuroinflammatory and neurotoxicity perspective: a review of the literature. Int Ophthalmol. 2019;39:259–271.
      Selvan H, Gupta S, Wiggs JL, et al. Juvenile-onset open-angle glaucoma—a clinical and genetic update. Surv Ophthalmol. 2022;67:1099–1117.
      Berchuck S, Jammal A, Mukherjee S, et al. Impact of anxiety and depression on progression to glaucoma among glaucoma suspects. Br J Ophthalmol. 2021;105:1244–1249.
      Méndez-Ulrich JL, Sanz A. Psycho-ophthalmology: contributions of health psychology to the assessment and treatment of glaucoma. Psychol Heal. 2017;32:330–342.
      Konieczka K, Ritch R, Traverso CE, et al. Flammer syndrome. EPMA J. 2014;5:11.
      Shin DY, Jung KI, Park HYL, et al. The effect of anxiety and depression on progression of glaucoma. Sci Rep. 2021;11:1769.
      Dayal A, Sodimalla KVK, Chelerkar V, et al. Prevalence of anxiety and depression in patients with primary glaucoma in Western India. J Glaucoma. 2022;31:37–40.
      Gubin D, Neroev V, Malishevskaya T, et al. Depression scores are associated with retinal ganglion cells loss. J Affect Disord. 2023;333:290–296.
      Abe RY, Silva TC, Dantas I, et al. Can psychologic stress elevate intraocular pressure in healthy individuals? Ophthalmol Glaucoma. 2020;3:426–433.
      Jiménez R, Vera J. Effect of examination stress on intraocular pressure in university students. Appl Ergon. 2018;67:252–258.
      Vera J, Redondo B, Álvarez-Rodríguez M, et al. The intraocular pressure responses to oral academic examination: the influence of perceived levels of public speaking anxiety. Appl Ergon. 2020;88:103158.
      Gillmann K, Weinreb RN, Mansouri K. The effect of daily life activities on intraocular pressure related variations in open-angle glaucoma. Sci Rep. 2021;11:6598.
      Gillmann K, Hoskens K, Mansouri K. Acute emotional stress as a trigger for intraocular pressure elevation in Glaucoma. BMC Ophthalmol. 2019;19:69.
      Keren S, Waisbourd M, Gomel N, et al. Influence of mental stress on intraocular pressure and visual field testing: is there a white coat syndrome in glaucoma? Graefes Arch Clin Exp Ophthalmol. 2022;260:209–214.
      Kim JH, Caprioli J. Intraocular pressure fluctuation: Is it important? J Ophthalmic Vis Res. 2018;13:170–174.
      Leidl MC, Choi CJ, Syed ZA, et al. Intraocular pressure fluctuation and glaucoma progression: what do we know? Br J Ophthalmol. 2014;98:1315–1319.
      Jacobs IA, Kowalski C. A method for inducing stress in a laboratory setting. Int J Soc Psychiatry. 1966;12:273–278.
      Edjah K, Ankomah F, Domey E, et al. Stress and its impact on academic and social life of undergraduate university students in Ghana: a structural equation modeling approach. Open Educ Stud. 2020;2:37–44.
      Ciociola EC, Klifto MR. Juvenile open angle glaucoma: current diagnosis and management. Curr Opin Ophthalmol. 2022;33:97–102.
      Joshua AO, Mabuza-Hocquet G, Nelwamondo FV. Assessment of the cup-to-disc ratio method for glaucoma detection. 2020 International SAUPEC/RobMech/PRASA Conference. IEEE; 2020:1–5. doi:10.1109/SAUPEC/RobMech/PRASA48453.2020.9041005.
      Sihota R, Angmo D, Ramaswamy D, et al. Simplifying “target” intraocular pressure for different stages of primary open-angle glaucoma and primary angle-closure glaucoma. Indian J Ophthalmol. 2018;66:495.
      Birla S, Gupta D, Somarajan BI, et al. Classifying juvenile onset primary open angle glaucoma using cluster analysis. Br J Ophthalmol. 2020;104:827–835.
      Mills RP, Budenz DL, Lee PP, et al. Categorizing the stage of glaucoma from pre-diagnosis to end-stage disease. Am J Ophthalmol. 2006;141:24–30.
      Zweben A, Piepmeier ME, Fucito L, et al. The clinical utility of the Medication Adherence Questionnaire (MAQ) in an alcohol pharmacotherapy trial. J Subst Abuse Treat. 2017;77:72–78.
      Cohen S, Kamarck T, Mermelstein R. A global measure of perceived stress. J Health Soc Behav. 1983;24:385–396.
      Cristóbal-Narváez P, Haro JM, Koyanagi A. Perceived stress and depression in 45 low- and middle-income countries. J Affect Disord. 2020;274:799–805.
      Lynch R, Flores-Torres MH, Hinojosa G, et al. Perceived stress and hair cortisol concentration in a study of Mexican and Icelandic women. PLOS Glob Public Heal. 2022;2:e0000571.
      Kim J, Aschard H, Kang JH, et al. Intraocular pressure, glaucoma, and dietary caffeine consumption: a gene–diet interaction study from the UK Biobank. Ophthalmology. 2021;128:866–876.
      Abokyi S, Sekyere NM, Ocansey S. Maximal incremental exercise improves macular photostress recovery time and lowers intraocular pressure in healthy athletes. J Sci Med Sport. 2023;26:646–649.
      Matlach J, Bender S, König J, et al. Investigation of intraocular pressure fluctuation as a risk factor of glaucoma progression. Clin Ophthalmol. 2019;13:9–16.
      Jayaram H. Intraocular pressure reduction in glaucoma: does every mm Hg count? Taiwan J Ophthalmol. 2020;10:255.
      Rabiolo A, Montesano G, Crabb DP, et al. Relationship between intraocular pressure fluctuation and visual field progression rates in the United Kingdom Glaucoma Treatment Study. Ophthalmology. 2024;131:902–913.
      Leske MC, Heijl A, Hyman L, et al. Predictors of long-term progression in the early manifest glaucoma trial. Ophthalmology. 2007;114:1965–1972.
      Bengtsson B, Leske MC, Hyman L, et al. Fluctuation of intraocular pressure and glaucoma progression in the early manifest glaucoma trial. Ophthalmology. 2007;114:205–209.
      Dada T, Mondal S, Midha N, et al. Effect of mindfulness-based stress reduction on intraocular pressure in patients with ocular hypertension: a randomized control trial. Am J Ophthalmol. 2022;239:66–73.
      Griffin S, Boyce T, Edmunds B, et al. Endogenous hypercortisolism inducing reversible ocular hypertension. Am J Ophthalmol Case Reports. 2019;16:100573.
      de Vocht F, Katikireddi SV, McQuire C, et al. Conceptualising natural and quasi experiments in public health. BMC Med Res Methodol. 2021;21:32.
    • Accession Number:
      0 (Antihypertensive Agents)
    • Publication Date:
      Date Created: 20240801 Date Completed: 20241104 Latest Revision: 20241104
    • Publication Date:
      20241104
    • Accession Number:
      10.1097/IJG.0000000000002478
    • Accession Number:
      39087943