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Evaluation of the adjuvant effect of imiquimod and CpG ODN 1826 in chimeric DNA vaccine against Japanese encephalitis.
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- Author(s): Zang X;Zang X; Li G; Li G; Zhu J; Zhu J; Dong X; Dong X; Zhai Y; Zhai Y
- Source:
International immunopharmacology [Int Immunopharmacol] 2024 Oct 25; Vol. 140, pp. 112816. Date of Electronic Publication: 2024 Jul 30.- Publication Type:
Journal Article- Language:
English - Source:
- Additional Information
- Source: Publisher: Elsevier Science Country of Publication: Netherlands NLM ID: 100965259 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1878-1705 (Electronic) Linking ISSN: 15675769 NLM ISO Abbreviation: Int Immunopharmacol Subsets: MEDLINE
- Publication Information: Original Publication: Amsterdam ; New York : Elsevier Science, c2001-
- Subject Terms: Imiquimod* ; Encephalitis, Japanese*/prevention & control ; Encephalitis, Japanese*/immunology ; Oligodeoxyribonucleotides*/pharmacology ; Oligodeoxyribonucleotides*/administration & dosage ; Adjuvants, Immunologic*/pharmacology ; Encephalitis Virus, Japanese*/immunology ; Vaccines, DNA*/immunology ; Toll-Like Receptor 9*/agonists ; Japanese Encephalitis Vaccines*/immunology ; Toll-Like Receptor 7*/agonists; Animals ; Mice ; Female ; Toll-Like Receptor 8/agonists ; Humans ; Adjuvants, Vaccine/pharmacology ; Mice, Inbred BALB C ; Mice, Inbred C57BL
- Abstract: Vaccines represent a significant milestone in the history of human medical science and serve as the primary means for controlling infectious diseases. In recent years, the geographical distribution of Japanese encephalitis viruses (JEV) of various genotypes has become increasingly complex, which provides a rationale for the development of safer and more effective vaccines. The advent of subunit and nucleic acid vaccines, especially propelled by advancements in genetic engineering since the 1980s, has accelerated the application of novel adjuvants. These novel vaccine adjuvants have diversified into toll-like receptor (TLR) agonists, complex adjuvants, nanoparticles and so on. However, the efficacy of adjuvant combinations can vary depending on the host system, disease model, or vaccine formulation, sometimes resulting in competitive or counteractive effects. In our previous study, we constructed a pJME-LC3 chimeric DNA vaccine aimed at inducing an immune response through autophagy induction. Building on this, we investigated the impact of the TLR7/8 agonist imiquimod (IMQ) and the TLR9 agonist CpG ODN 1826 as adjuvants on the immunogenicity of the Japanese encephalitis chimeric DNA vaccine. Our findings indicate that the combination of the pJME-LC3 vaccine with IMQ and CpG ODN 1826 adjuvants enhanced the innate immune response, promoting the maturation and activation of antigen-presenting cells in the early immune response. Furthermore, it played a regulatory and optimizing role in subsequent antigen-specific immune responses, resulting in effective cellular and humoral immunity and providing prolonged immune protection. The synergistic effect of IMQ and CpG ODN 1826 as adjuvants offers a novel approach for the development of Japanese encephalitis nucleic acid vaccines.
Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
(Copyright © 2024. Published by Elsevier B.V.) - Contributed Indexing: Keywords: Adjuvant; DNA vaccine; Innate immunity; Japanese encephalitis; Toll-like receptor agonist
- Accession Number: P1QW714R7M (Imiquimod)
0 (Oligodeoxyribonucleotides)
0 (Adjuvants, Immunologic)
0 (Vaccines, DNA)
0 (Toll-Like Receptor 9)
0 (Japanese Encephalitis Vaccines)
0 (CpG ODN 1826)
0 (Toll-Like Receptor 7)
0 (Toll-Like Receptor 8)
0 (Adjuvants, Vaccine) - Publication Date: Date Created: 20240731 Date Completed: 20240831 Latest Revision: 20240831
- Publication Date: 20240831
- Accession Number: 10.1016/j.intimp.2024.112816
- Accession Number: 39083930
- Source:
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